<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28701

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSNDCSMYRLEDLLSSFYKIESIEKINYHQYVPKKQDDQWSIQMELYLRKQSSRNLVALLSRELWCFSINDDPVPTPPKLSATGDDVTTLDKSGQFTAHYSKPNLPPHYALFLKALRRMLYINLTAKACNKLVPFGNACISLEGMKQSQILQLEPHLFENGDLAITISTKNLQLLPLTVENINESFLRRHALYLAPSGIRMYLSSSDKQCLVNPPKNAEILLKTLFISHGIELPDKNEVQWVKVIPNLNHLNGYTPNIAAYMDPPLDTRTITWPLSLCFAQTALDAKDQSDGDLSCHDLHEAFDVIDDFNQLKQTSAYRTPSSSGGALGNSLGTNPLSSGGGYTEQFQHFYKNPAWSSQSANDNVAPKISPRVSSPSYSTFDKALPGSSETFAGVAGLTTPSINENEFSDRRGLTNGFELTPVKSDVTLNLKRCLNDREPIPKTVSPSQPSDGMIEDGACSDSVVDKELFGEEEEEEDDNLFGESSQSSANPGESKSFTPGKAGTDEITEDMFGMSDDEDGSRSTTSKSGAFFLENEAELRIQPSKRSSMKRKYLDIPMEEMTLSNSPLYMDPGAPLPVETPKDRRKSVFAPLNFNPIIENNVDNKYKNGGKFSFSPSQHEESLKFDVSTADISSSEDESESSVDFDDLNIKPEAISSENNLRDAQYNLYSSIQAPLDSVPPNVNKVDLLPSNIPGTGELIKETSNGIWKINNQEMGQSDPLITSGGGSIPSAQAKNDRYSFLSRGYLTGGTNSSNLPESDSGVPETTPANVSLLPESSSSLPFLLRHMPLSSMPSVFSCSNPTVTITKNDQYILAILAEQVVFDYNIFNGFGKPQILNSGLKDCQKGLIAETIRELFSSFSRVHGNELISSLSTIKEPSIYVKKHHSMMNMSADSQVFSKFLNVKPAKGIKNFRFLMLTTSYAEDCLSFVSTLCQTYIGYEFGFCELLKLTSDDSQGLMQLPDFDKSRLLLLAAQIVTYCSTNKNAGKDVPVMILLPIECYKLEELTSKVAKFEIIHNEVTSKIPNAQIYLKVVLMDFIRSPLTSVDDYNNLCVSVYNILPPKTVKFTSIAHKLPEKVTFRTLQQSAGTAAIGYDTYIHLAYARSVDKEWVFAAFSDSSGNESLIKQWYVGTSKTRFDEACNEIWGLALHLSAKKFGKICLILTRLNGVLPDDELMNWRRLSGKAIHLAVVCVDDDTKISFFDEDKMYPTFKPLYENQELTRKVDPRRLDDYEIRDIAQDVHGVIFESCFPLTNSQHRCAIKSGALMKFKRSAGDSIVDKFEVNLLNCPHSDSTKLLETILREFRNLGALSSWFGVSNGENAHIPWHVLAVKK
Length1334
PositionKinase
OrganismTorulaspora delbrueckii (strain ATCC 10662 / CBS 1146 / NBRC 0425 / NCYC 2629 / NRRL Y-866) (Yeast) (Candida colliculosa)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Torulaspora.
Aromaticity0.09
Grand average of hydropathy-0.357
Instability index50.32
Isoelectric point5.28
Molecular weight148466.04
Publications
PubMed=22123960

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi
GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi
GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28701
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.25|      17|      17|     749|     765|       1
---------------------------------------------------------------------------
  749-  765 (32.37/18.62)	TGGTNSSNLPESDSGVP
  767-  783 (30.88/17.40)	TTPANVSLLPESSSSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.62|      14|      17|     614|     627|       2
---------------------------------------------------------------------------
  614-  627 (25.80/13.39)	SFSPSQHEESLKFD
  634-  647 (23.81/11.83)	SSSEDESESSVDFD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      71.31|      16|      17|    1127|    1142|       3
---------------------------------------------------------------------------
 1109- 1125 (21.30/10.07)	KEWvFAA..FSDSSGNESL
 1127- 1142 (28.71/16.03)	KQW.YVG..TSKTRFDEAC
 1144- 1161 (21.30/10.07)	EIW.GLAlhLSAKKFGKIC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.26|      14|      17|     354|     367|       4
---------------------------------------------------------------------------
  354-  367 (26.98/14.96)	PAWSSQSAN..DNVAP
  371-  386 (21.28/10.18)	PRVSSPSYStfDKALP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.08|      10|      18|     151|     160|       5
---------------------------------------------------------------------------
  151-  160 (19.37/11.01)	LQLEPHLFEN
  172-  181 (17.71/ 9.43)	LQLLPLTVEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.64|      53|     812|     401|     467|       6
---------------------------------------------------------------------------
  410-  467 (83.09/70.20)	DRRGLtNGFELTPVKSDV.TLNLKRCLndrePIPKTVSPSQPSDG..MIEDGACSDSVVDK
 1226- 1281 (84.55/42.80)	DPRRL.DDYEIRDIAQDVhGVIFESCF....PLTNSQHRCAIKSGalMKFKRSAGDSIVDK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     221.80|      68|     200|      11|      85|       7
---------------------------------------------------------------------------
   11-   85 (111.45/84.76)	EDLLSSFYKIESIEkinyhqyVPKKQDDQW.SIQMELYLRKQSSRNLVALLSREL......WCFSINDDPVPTPPKLSATGD
  219-  293 (110.35/69.04)	EILLKTLFISHGIE.......LPDKNEVQWvKVIPNLNHLNGYTPNIAAYMDPPLdtrtitWPLSLCFAQTALDAKDQSDGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      82.93|      28|     383|     324|     353|       9
---------------------------------------------------------------------------
  324-  353 (48.42/28.29)	SGG..ALGNS.LG.TNPL.SSGGGYTEQFQhfYKN
  705-  737 (34.52/14.26)	SNGiwKINNQeMGqSDPLiTSGGGSIPSAQ..AKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.49|      29|      78|     108|     138|      11
---------------------------------------------------------------------------
  108-  138 (47.27/36.17)	HYALFLKALRRMLYINLTAKACnkLV.PFGNA
  189-  218 (49.22/31.19)	RHALYLAPSGIRMYLSSSDKQC..LVnPPKNA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28701 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ETFAGVAGLTTPSINENEFSDRRGLTNGFELTP
2) LKFDVSTADISSSEDESESSVDFDDLNIKPEA
3) LKRCLNDREPIPKTVSPSQPSDGMIEDGACSDSVVDKELFGEEEEEEDDNLFGESSQSSANPGESKSFTPGKAGTDEITEDMFGMSDDEDGSRSTTSKSGAFFLENEAELRIQPSKRSSMKRKYLDIPM
390
624
431
422
655
559










Molecular Recognition Features






MoRF SequenceStartStop




1) MKRKYLDIPMEE
550
561