<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28692
Description |
Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MLSRKEEDKSLMSLPITRVNSSQQLSHNGLHGSHLKTTNSYVSIPPSPSNITSASQRQIPVGNKIGRRGIRTDKSSTSTIGVLTKIDDFETALKELSFKVSTYSTEDLPSAVENLLHINDEILHEIDNLQEQQRLGARIETLSDASQSLRAKTKEILKGLIESRNRLRKLPKLLRKNEQSTSEYTSDVDVEVEELLKYAQKLSKFTKAPNVSISLPFQVHPNNYVWPAEDALRRGMLALSSLKENEILKSELDEDEDLAELDSSEDIKKAPASPVLETNDVKQEPSITDEPVKEDQSNTLDMDLFDPDAEDFSE |
Length | 314 |
Position | Middle |
Organism | Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL Y-12695) (Hybrid yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Debaryomycetaceae> Millerozyma.
|
Aromaticity | 0.04 |
Grand average of hydropathy | -0.687 |
Instability index | 61.31 |
Isoelectric point | 4.95 |
Molecular weight | 35199.88 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP28692
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 122.75| 40| 90| 152| 191| 1
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152- 191 (64.09/41.63) KTKEILKGLIESRNRLRKLPKL..LRKNEQSTSEYTSDVDVE
243- 284 (58.66/37.50) KENEILKSELDEDEDLAELDSSedIKKAPASPVLETNDVKQE
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