<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28683

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMERIHPKNVLTNYYKIGHINEVDIYVYGTKTKKNDQYLLELELEIRNIYPKVLVTYYNKFLFQFHFCFLETKIDLSTLYPDLYQESFFKVKTDVLANPNKPGYSPYCNVSFLKATKKLFLYSLSKSNKLKLFGNHAITKKNDGTYRILQIDPILLSNGDIYISVFEKLDPYFFDSALISPDEMIKSDLTYIIYLIPSGIRCHLYSSEDISSSFTKEAPDHSKDLLELIKMSTGIDLCGERELLWVKLVPNLQHLNNQTSKIAQFIHTVTNKKTILWPWCLCVLQYGFCEEEIGKDDVNDKLSDPLNVIADFIELNIEYKNSNNTLDQNNGTHTNANLSDPSFLSTGLSSVGPYNDLKSDSNLEEYIQTNEAQRNHILSPQSSAAVTNSSKSENQPKEEDEEVDEINDLFGDASDGSDAEMSSLADQNIQGKMGTKSDINSDDNRELDESPTAYQLEKNEKEDHNMELGGAVDRESQNKGTFIDIPKDQMTINLAKPMKLQSPRIYSDPGAPLPMDPTPILPQGNFAFGNNSVNALAGSNNNTSESEQPKSRSIFSPIPLFNPIIKSNIDTKYGKGGKFYVEKETTLDSDSRRNVLRATSISGNDLALVEDNMKGSEKLINRATHEDVITPSAKRFSQSKPSFSADELPSKETFKRQIAPDYDGEQTSTLAMGFTDEVIQGEGDYDPEGDSSEDADEEEEEEESDEDDDMTQDNVFSNSSYALKLNTFNGPQDLTVNAGNGSQEGVHQQDHDQVNQGLLRFSNMNEGTIVNKHLKTSAISPSNTGNYSGNSDNVLLSPQEMDQDNMQDSLGTQGPVSLDENIERTIGSTFMKKELTEKGESTPRTSSVSESSNCLPLILRNVNINTIPERYILNNLSQKSVLSSKSEFSMELEDRDEKSDFELRRGNEMRVSISNIDLFLTNINSNLIFDDSVNDFFQNMKLNNPIQEKKYSTLCYNCKTPDEDVEKKLFEVFPFMLRSRLNEFMREESNGSIFDDDVQARNPMNNEIGFLGDIADESLLHPNSQEKEPKSLEWICFSEKEESNSLGFNSYVKAMKEHSDATTDKVSEEQNLFQLCFNKIKIISASEKEINLNSISLRFWKYLNFKPLHGPKNFQLLIISEQRHGVYRDELTGFLNSLIYNYKNSNFGEISKVSLMNINSETGTSTVNDGVLTLDDQQLYTSNNEFYLKVNKNLDTVAELIKLDLINKSNRFEFDRPLLLLFVNFDKRLNSLVQLSSLYRNFMLFLRKHHVPLVEVFSHIIPFEELIHEVKGFRRFKYLSSYHLTRLSMNLYNKCPEIISHSKGDIFQPKKLFTQFIKEPPHKLHFKFLDSNNGNIDTEYIDDVFLHFAYERSIDKRWMVGAWTDPLGMVTNVKSWYCKNQKKNDNDIFDLESICDDIWEISSSLFKALNEEMANQMSCFGGKKFLVLTRINSVIPDDELVHWKRLSSKNKDISLIVLSADNKARLLAGDDDIDKAVANMQQPLIEQNYESPSPEFSKFFGSGYNSNPSTQPSPSNTIGALGTSPPTNSSMHSPYQFLNMPGNYLSPQDLIPSNTGHSAPQSNDNNSHMGAEDLILQDVSQIITAFIPKVTLPSCHSPLKYCLKMGYLIKPYQFKPQRDSRSFLAFEVSLLSCSNYWNLDAIMRIILKHYKKLISLGDILCVENNFSSNYRTGTNGLVPWHVAAVSKSLDYLVHVDVEE
Length1698
PositionKinase
OrganismPichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL Y-12695) (Hybrid yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Millerozyma.
Aromaticity0.09
Grand average of hydropathy-0.552
Instability index41.90
Isoelectric point4.97
Molecular weight192846.81
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



	RuleBase:RU364134

GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28683
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.30|      27|      39|     301|     338|       1
---------------------------------------------------------------------------
  301-  338 (37.43/46.22)	LSDPLNVIADfielnieYknsnNTL..DQN.......NGTHTNANLS
  343-  378 (37.87/20.79)	LSTGLSSVGP.......Y....NDLksDSNleeyiqtNEAQRNHILS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.70|      42|      43|     711|     753|       2
---------------------------------------------------------------------------
  684-  714 (38.94/15.78)	............YDPEGDSSE......DADE..EEEEEE..SDEDDDMTQDNV
  715-  757 (67.98/36.62)	FSNSSYALKLNtFNGPQDLTV......NAGN..GSQEGV..HQQDHDQVNQGL
  760-  802 (34.78/13.58)	FSNMNEGTIVN.....KHLKTsaispsNTGNysGNSDNVllSPQEMDQ.....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.56|      10|      41|       4|      14|       3
---------------------------------------------------------------------------
    4-   14 (16.89/13.29)	IHPKnVLTNYY
   48-   57 (20.68/11.06)	IYPK.VLVTYY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.30|      33|      40|     814|     851|       4
---------------------------------------------------------------------------
  814-  851 (45.42/45.84)	PVSLDE.NIErTIGSTFMKKELTEKGestpRTSSVSESS
  855-  888 (51.87/34.93)	PLILRNvNIN.TIPERYILNNLSQKS....VLSSKSEFS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     107.46|      31|      40|    1091|    1128|       5
---------------------------------------------------------------------------
 1028- 1057 (40.45/21.62)	.PKS.LEWICFSEK...............eESNSLGFNSYVKAMKEH
 1067- 1108 (36.59/18.80)	EEQNlFQLCF....nkikiisasekeinL.NSISLRFWKYLNFKPLH
 1109- 1146 (30.43/26.98)	GPKN.FQLLIISEQ..rhgvyrdeltgfL.NSL.IYNYKNSNF....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      79.65|      18|      44|     425|     442|       6
---------------------------------------------------------------------------
  425-  442 (32.42/19.50)	DQNIQGKMGTKSDINSDD
  462-  471 (16.78/ 6.36)	DHNME..LG......GAV
  472-  488 (30.44/17.84)	DRESQNK.GTFIDIPKDQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.86|      20|     764|     553|     572|       7
---------------------------------------------------------------------------
  553-  572 (39.56/23.34)	IFSPIPLFNPIIK...............SNIDTKY
 1305- 1339 (29.30/15.30)	IFQPKKLFTQFIKepphklhfkfldsnnGNIDTEY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.71|      11|     106|      31|      42|       8
---------------------------------------------------------------------------
   32-   42 (19.50/14.27)	KKNDQYLLELE
 1381- 1391 (20.21/ 8.30)	KKNDNDIFDLE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     296.63|      93|     276|     889|     986|       9
---------------------------------------------------------------------------
  889-  986 (151.52/122.67)	MELEDRD...EKSDFELRRGNEMRVSISNIDLFLTNINSNLIFDDSVNDFFQNM..KLNNPIQekkYSTLCYNCKTPDEDVEKKLFEVFPFMLrsRLNEFMRE
 1171- 1268 (145.11/103.48)	LTLDDQQlytSNNEFYLKVNKNLDTVAELIKLDLINKSNRFEFDRPLLLLFVNFdkRLNSLVQ...LSSLYRNFMLFLRKHHVPLVEVFSHII..PFEELIHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.37|      17|      40|     160|     181|      10
---------------------------------------------------------------------------
  160-  181 (22.38/22.69)	IYISvfEKLDPYFFDSAlisPD
  203-  219 (29.99/14.70)	LYSS..EDISSSFTKEA...PD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.46|      32|     508|     990|    1021|      11
---------------------------------------------------------------------------
  990- 1021 (57.68/31.34)	GSIFDDDVQARNPMNNEIGFLG.DIADESLLH.P
 1500- 1533 (51.78/27.37)	GSGYNSNPSTQPSPSNTIGALGtSPPTNSSMHsP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      99.89|      32|      40|     574|     605|      12
---------------------------------------------------------------------------
  574-  605 (51.99/33.31)	KGGKFYVEKETTLD...SDSRRNVLRATSISGNDL
  613-  647 (47.90/30.07)	KGSEKLINRATHEDvitPSAKRFSQSKPSFSADEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.21|      15|      30|     239|     253|      13
---------------------------------------------------------------------------
  239-  253 (26.44/14.67)	ERELLWVKLVPNLQH
  271-  285 (30.76/18.08)	KKTILWPWCLCVLQY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28683 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DSRRNVLRATSISGNDLALVEDNMKGSEKLINRATHEDVITPSAKRFSQSKPSFSADELPSKETFKRQIAPDYDGEQTSTLAMGFTDEVIQGEGDYDPEGDSSEDADEEEEEEESDEDDDMTQDNVFSNSSYALK
2) MTINLAKPMKLQSPRIYSDPGAPLPMDPTPILPQGNFAFG
3) NTFNGPQDLTVNAGNGSQEGVHQQDHDQVNQGLLRFSNMNEG
4) SDSNLEEYIQTNEAQRNHILSPQSSAAVTNSSKSENQPKEEDEEVDEINDLFGDASDGSDAEMSSLADQNIQGKMGTKSDINSDDNRELDESPTAYQLEKNEKEDHNMELGGAVDRESQNKGTFIDIPKD
5) VNKHLKTSAISPSNTGNYSGNSDNVLLSPQEMDQDNMQDSLGTQGPVSLDENIERT
589
489
725
358
769
723
528
766
487
824










Molecular Recognition Features






MoRF SequenceStartStop




NANANA