<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28676

Description Piso0_005175 protein
SequenceMRSRNSSSLPSTENSKENEYKKDLLSMKYQLEVPDVQIYPLNKIDNIEDTYDEIKHDNLTKEKSNLTYPDFVPWLDHTQLKKEASEAEVEALNNSTYLNRGYYETPSVSNEYYSARNVVQPALFESNNCENILNEMSQHLINAYKERQEVINKIKFDSNKFKLPQRVTLTASKREAWFRDLSSPDIPLEKISSKLPHGVKNKVLIEMLCNKSVPMSRALWFTRCILYHEIVSVRKKYHFKQYSVQSLTLQDSLEHRWLCEWTGQCSEYIYRFSKEMGNISTPERKSGYLGKLNYLLSYMSVLYMERLIDRESFISSFLSYMKESLPLEGDYIPTLVSLLKTDSNSVLAKWISRLDINFGYTLVGLALVKTFWNEILKIDHLSKKLAEALLLNHFFLKQTYPLSPKTQKPTSPRKFVMSTEIKKQILSSLSDMISYLFKYNNNAFVIPTYWLIVKDTLNNILLDDRKTQLNIGEKEETKKQTNLINYRNESLMLNMRCEHPTRSANDFNSVSDNSNEKETQEGSSTLINSKIYEELSLSDDGGLIRRSNDDILSIIEQLDRLKLGSNISDMIKPVPLAAQIEKQSLWRISLKILIHWAITAYRPKSTSSENILILCNFIKRNTGRNNTVKGSSKFKMKIENEILDIIYEIAEANDRIVNSNFYVLINELYQLKLITISGYLRKLIASGVFYLSTEEEKSSEMKLNAQIRMHLSILENLPVLNNRQCDSILKKWTSNNYDFKVKLEDSKEILAKKVLEKMKNNSFEDESFKVFEPIENLEVGLKYLLVNWFTNELKNFINSSSRLIHISTNTVSWLYHFFSICDNLAVFFKVVLRLILKNEGKVIVFYMDSLYLMSKLMVRHFDLLKYLPGMLSSTTTLELSELIVINYKDLLSRDTDCYNFKKIWKFIDSAIENDELKLKEEAEVVADDVVDNRDTSNDLGIADSSYYSEQNFKKDIISFIVEPDNIVNNSEIDDLLDSLNPKLKELITSYEGSKEAIQWLIGSYYKVINNDDGIAEAQYLKILRVCSKLLMKEDQLDGQKAIFSGIIKIFDDSAFDKSKALLLLKKLLITEAYDVSDALKFIKEELNVSEEEKLAMRYELAFGDSQCVQENLLSPSEKITLSCVHEDYIKSNYKALFTFLLEDMGSENDDIFASKPFMEYIDEILDLFKKVIPLHTKFSSDKLSKFMRREQIILLFNKMLFINDEPIISLKDIPRLSSIVDEFNLPYVQLLIKNIIENLENRNDNETTENLKSIIEKFLNNVKTKFSMDNAYFGELFAYAPWDYQLKIFNILEDMVLLRTTFPQDEKDEKEPGDKCNVALSSETGHNLLPLINASFKKFSLSQVFTVPTSLGFFHKLSKFSSKILNLATSERSFDKDFDADFYNMVSIYLRIIIIHKTTLASKLVEVDPQMSFIKGLVSLFNSNFFNESHEKLKILLYDLLLLLKSLVISSYSNESEGNLLETLPTPNIAASATTYQSPADETNASKNGNSPSAGSKEAFVDRKGLYANAPRHMASNLSLIGHLQQPLCINTLKVYINPSSVENVLTIGENEFIKNSDIQVVNDPNLCLVPSRRAAAYNDFSILGDSSKEKVQPKRFRLRSYELLEDTSSHLNDGCISLSIFDAFVSRENIP
Length1632
PositionKinase
OrganismPichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL Y-12695) (Hybrid yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Millerozyma.
Aromaticity0.10
Grand average of hydropathy-0.297
Instability index41.17
Isoelectric point5.72
Molecular weight188131.28
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28676
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     675.28|     166|     177|     798|     974|       1
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  688-  773 (104.85/57.26)	...........................................................................VFYLST.EEEKSSEM...............KLN..AQIRMHLS..ILENLPVLNNR..QCDSILKKWT...SNNYDFKVKLEDSKEILAKKVLEK........MKNNSFEDE.SFK......VFEP
  794-  963 (263.15/170.65)	KNFINSS....................SRLIHISTNTVSWLYHFFSICDNLAVFFKVVLR.LILKNE....GKVIVFYMDS.LYLMSKLMVR..HFDLLK.YLPGMLS..STTTLELSELIVINYKDLLSRDTDCYNFKKIWKFIDSAIENDELKLKEEAEVVADDVVDNRDTSNDLGIADSSYYSEQNFKkdiisfIVEP
  964- 1111 (154.94/94.66)	DNIVNNSeiddlldslnpklkeliTS....YEGSKEAIQWL.........IGSYYKV.....INNDD....GIAEAQYLKI.LRVCSKLLMKedQLDGQKaIFSGIIKifDDSAFDKSKALLL.LKKLLI..TEAYDVSDALKFI...........KEELNVSEEEKLAMR...YELAFGDSQCVQEN.............
 1113- 1244 (152.34/90.80)	........................LSpSEKITLSC......VHEDYIKSNYKALFTFLLEdMGSENDdifaSKPFMEYIDEiLDLFKKVIPL..H...TK.FSSDKLS..KFMRRE..QIILLFNKMLFINDEPIISLKDIPR.LSSIV..DEFNL.PYVQLLIKNIIENLENRND.........................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     432.80|     148|     404|      10|     177|       2
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   10-  177 (230.88/196.01)	P.STENSKENEYKKDLLS..MKYQL..EVPDVQIYpLNKIDN...IEDTYDEIKHDNLtkekSNLTYPDfvpwlDHTQL...KKEASEAEVEALN...NSTYLN.RGYYETPSvSNEYYSARNvvqpalfesNNCENILNEMSQHLINA..YKERQ...................EVINKIKFDSNKFKLPQRVTLTAS..KREAW
  401-  586 (201.92/130.23)	PlSPKTQKPTSPRKFVMSteIKKQIlsSLSDMISY.LFKYNNnafVIPTYWLIVKDTL....NNILLDD.....RKTQLnigEKEETKKQTNLINyrnESLMLNmRCEHPTRS.ANDFNSVSD.........NSNEKETQEGSSTLINSkiYEELSlsddgglirrsnddilsiiEQLDRLKLGSNISDMIKPVPLAAQieKQSLW
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.80|      11|      26|    1423|    1433|       6
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 1423- 1433 (20.34/10.19)	SNFFNESHEKL
 1450- 1460 (19.46/ 9.42)	SSYSNESEGNL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.95|      12|      19|    1338|    1350|       7
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 1338- 1350 (17.65/11.78)	KFSlSQVFTVPTS
 1359- 1370 (20.30/ 9.23)	KFS.SKILNLATS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.61|      25|    1138|     299|     339|       8
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  311-  335 (43.27/47.09)	ESFISSFLSYMKESLPLEGDYIPTL
 1252- 1276 (42.34/13.36)	KSIIEKFLNNVKTKFSMDNAYFGEL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.36|      21|     933|     590|     619|       9
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  590-  619 (26.89/41.39)	LKILIHwaitayrPksTSSENILIL..CNFIK
 1533- 1555 (32.47/20.31)	LKVYIN.......P..SSVENVLTIgeNEFIK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28676 with Med12 domain of Kingdom Fungi
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