<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28668

Description Piso0_005175 protein
SequenceMMRSRNSSSLTSNEISKENEYKKDLLSMKYRLEVPDVQIYPLNKIDNIEDTYDEIKHDNLTKERSNLTYPDFVPWLDHTQLKKEASEAEVEALNNSTYLNRGYYETPSVSNEYYSARNVVQPALFESNNCENILNEMSQHLINAYKERQEVINKIKFESNNFKLPQRVTLTASKREAWFRDLSNPDIPLEKISSKLPHGVKNKVLIEMLCNKCVPMSRALWFTRCILYHEIISVRKKYHFKQYSVQSLTLQDSLEHRWLCEWTGQCSEYIYRFSKEMGNISTPERKQSYLVKLNYLLSYMSVLYMERLIDRESFITSFLSYMKESLPLEGRYIPTLVSLLKTDSNSVLAKWISRLDINFGYTLVGLALVKTFWNEILKVDHLSKKLAEVLLLNYFFLKQTYPLSPKTQKPRAPRKFVMSSEIKQQILSSLSDMISYLFKYNNNAFIIPTYWLIVKDTLNNILLDDRKTQLNTGEKEETKKQTNLINYRNESLMLNMRCEHPTRSANDFNSVPENPNEKETQEGSSKLLNSRIYEELSLSDDGGLIRRSSDDILSIIEQLDRVKLDSNISDMIKPVPSSASIEKQSLWRISLKILIHWAVTAYRPKSASPENILILCNFIKRNTSRNNTVKGSSKLKLKIESEILDIIYEIAEANDRIVNNNFYVLINELYQLKIITISGYLRKLIASGVFYLSSEEEKSSEIKFNPQIRMHLSILENLPVLNNRQCDSILKKWTSNSYDFKAKLEDSKNILASKVLEKMKNNSFEDESFNVFVPIQNLEIGLKYLLVNWFTNELKNFINSSSKLIHINTNTVSWLYHFFSICDNLAVFFKVVLRLILKNEGKVIVFYMDSLYLMSKLMVRHFDLLKYLPGTLSSTTTLELSELIVINYKDLLSRDTDCYNFKKIWKFIDSAIENDELKLKEDAEIAAADVVNNRDTSNDLGSADTSYYSEQNFKKDIIAFIVEPDNIVNNSEIDDLLDSLNAKLKELVTSHEGLKEAIQWLIGSYYKIINNIGDTVEAQYLKILRVCSKLLMKEDQLDGQKAIFSGIMKTFDDSAFDKGRALLLLKKLLIIEAYEISDALKFIKEELNLSEEDMLSMRYELAFGDSQCGQENLLSPSEMIVLNCIREDYIKMNDKTFFTFILEDMGSDDDDPFASKPYSEYIDQILDLFKKVIPLHTKFSSDKLSKFMSGEHIISLFNKMLFINDEPIISMKDIPRLSSIVDEFNLPYVQLLIKNIIENSENRNENETTENLKSIIEKFLNNVKTKFSMDNAYFGELFAYAPWDYQLKIFNILEDMVLLRTTFPQDEKDEKEPGSGCNIALYSERGHNLLPLINASFKKFSLSQVFTVPTSLGFFHKLSKFSSKILSLATSDKTFDKDFDVNFYNTVSIFLRIIIIHKTTLASKLVEVDPQMSFIKGLVSLFNSHFFNESHEKLKILLYDLLLLLKSLVISSYSNESESNLLETLPTPNIAASATTYQSPADDANAPKNGNSPSASSKETFVDRKGLYANAPRHLASNLSLIGHLQQPLCINTLKVYINPSSVENVLTIDEHEFVKNSDIQVVNDPNLCLVPSRRAAAYNDFSILGESSKEKVQAKRFRLRSYELLEDTSSHLNDGCISLSIFDAFVSRENIP
Length1633
PositionKinase
OrganismPichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL Y-12695) (Hybrid yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Millerozyma.
Aromaticity0.10
Grand average of hydropathy-0.289
Instability index42.24
Isoelectric point5.85
Molecular weight188360.51
Publications









Function






Annotated function


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28668
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.60|      23|      24|    1453|    1475|       1
---------------------------------------------------------------------------
 1453- 1475 (36.98/18.41)	Y.SNESESNLLETLPTPNIAASAT
 1477- 1500 (34.62/16.80)	YqSPADDANAPKNGNSPSASSKET
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.46|      11|      32|    1087|    1097|       2
---------------------------------------------------------------------------
 1087- 1097 (19.23/10.90)	LNLSEEDMLSM
 1122- 1132 (21.23/12.85)	LNCIREDYIKM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.12|      27|      30|     139|     168|       3
---------------------------------------------------------------------------
  111-  130 (22.88/ 9.45)	.NEYYSA...RNVVQ.PALFESNNC......
  142-  168 (46.37/34.67)	INAYKER...QEVIN.KIKFESNNFKLPQRV
  170-  200 (31.88/13.58)	LTASKREawfRDLSNpDIPLEKISSKLPHGV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.09|      27|      34|     916|     942|       4
---------------------------------------------------------------------------
  922-  955 (38.53/23.31)	D..AEIAAAD.VVNNRDTSNDLGSadtsyysEQNFKK
  956-  986 (32.57/18.42)	DiiAFIVEPDnIVNNSEIDDLLDS......lNAKLKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.26|      21|      25|    1153|    1173|       5
---------------------------------------------------------------------------
 1153- 1173 (36.42/21.48)	FASKPYSEYI..DQILDLFKKVI
 1179- 1201 (31.84/17.82)	FSSDKLSKFMsgEHIISLFNKML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.59|      13|      32|    1217|    1230|       6
---------------------------------------------------------------------------
 1217- 1230 (18.80/17.22)	LSSIVDEFnLPYVQ
 1252- 1264 (21.79/13.72)	LKSIIEKF.LNNVK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.58|      24|      27|     554|     580|       7
---------------------------------------------------------------------------
  557-  580 (41.01/32.90)	EQ.LDRVKLDSNISDMIKPV.PSSAS
  583-  608 (34.57/18.12)	KQsLWRISLKILIHWAVTAYrPKSAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     153.79|      51|     647|      49|     101|       8
---------------------------------------------------------------------------
   49-  101 (84.60/57.37)	EDTYDEIKHDnlTKERSNLTYPDFVPWLDHTQ....LKKEAS.....EAEVEALNN...STYLNR
  696-  758 (69.19/40.78)	EEKSSEIKFN..PQIRMHLSILENLPVLNNRQcdsiLKKWTSnsydfKAKLEDSKNilaSKVLEK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     100.27|      31|     508|     326|     384|      10
---------------------------------------------------------------------------
  352-  382 (53.58/63.70)	ISRLDINFGYTLVG..LALVKTFWNEILKVDHL
  775-  807 (46.69/11.37)	IQNLEIGLKYLLVNwfTNELKNFINSSSKLIHI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.32|      23|     508|     518|     544|      11
---------------------------------------------------------------------------
  519-  541 (38.89/37.88)	ETQEGSSKL...LNSRIYE...ELSLSDD
  627-  655 (27.43/ 8.42)	NTVKGSSKLklkIESEILDiiyEIAEAND
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.93|      24|      30|    1361|    1390|      17
---------------------------------------------------------------------------
 1336- 1359 (41.19/25.13)	SFKKFSLS...QVFTVPTSLGFFHKLS
 1362- 1388 (34.74/30.05)	SSKILSLAtsdKTFDKDFDVNFYNTVS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28668 with Med12 domain of Kingdom Fungi
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