Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MSESEGKSENFIQDRLDALSSIDGSIVSLLKSFSSLFQTYSNSKTDQNPTRYQDDITENTKNIYKNISDVAISLRKEVKLLDENIGVFGKNKSNIMILPIAVDQKNTKLGKKKMDYEVEQLDKLMEKDSKYQESTKENADVTEGAEKDQQENEADAVKKEDNYE |
Length | 164 |
Position | Head |
Organism | Pichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL Y-12695) (Hybrid yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Millerozyma. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.978 |
Instability index | 38.29 |
Isoelectric point | 4.74 |
Molecular weight | 18662.44 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP28667 No repeats found |
MoRF Sequence | Start | Stop |
1) EGKSENFIQDRLDA 2) KMDYEVEQLDKLMEKDSKYQESTKENADVTEGAEKD 3) NIMILPIAVDQKNT 4) PTRYQD 5) QENEADAVKKEDNYE 6) SIDGSIVSLLKSFSSLFQTY | 5 113 94 49 150 21 | 18 148 107 54 164 40 |
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