<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28664

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMRNGSRRFSIIELVHTMNGENTPRAGKINGDKREEDPMSNADSKSNGQEELLMKNGGKTGPPSIPHITNNIIPLSNILKYYSQTAYKQLTNIIDNLSNNQETESDLNRKKAFLQVIISMRQDFVKIYTLVKWASVSKDVSKLIDLLNWFRSQDFFFEQLGFGLNELNRYSGAKLPNSDIITALDVFIKKRPQLPSYNFIKTPPVSPEKILEVFENLNLSLSARLALMDDLPPRFARHFEVQDGRIYFTIPNEFMVSVTAPNDLIIDSVDDYSRSPFYFIDFKFLFGINPDNTLISHKKNKIATSLPRSSFIRLEGIANNVLLTRGLQGLYDLLHRYAISFKLYLLYKQLKDLAINSRWRNNIKYKYDNSKSLLIINYWSNHHSSRNWKSFIELGIDKNYHLNYRWFKNGVYDTTNKFSISFGRSSQSEVTSGDTLDAQDHDLPDDVAEDAGDEIIDLNIDTILTSVASKHAEIVMDHLFEKLKGNLASDLDNSCTRTSIHQIKIKLTPRKSAILSLNLLSGFFYFTDPSPIQNQAIKQMNFPSYNNNRGKAFFTEADMIDYCVSSLVQLRLHMYGKEIGNKLSTNEWINNDIISLNEYETAKLFNYSVNQLVGNPNSTLIYFYRCKNWPSSWFLVNMINGLHFSTFWWVARIKSIKGEWKIQWVRNLGVTEDSNQVADITLNYDFFFSLSNTCSNMILDHMILEQLQLRDIHFIKSDSRDKWLQALDKHGLNNVSGTLFDEQTSDSTYESMIILYNNNLIPVNNSSSSLFLLVRLSNLNSTTQMSLCLFGKVRNIPNGLSDIADSSIKIKKIEEYFTINDSINLSNEINDNYALENNLLGGIFLHLERLSKLIKILHQLHSNNSKVIENTINSIEVEFPNDLRSVTITLPEDQDSIKLASRADESSEQKLIIDNINRYLEANKAKEGVIGALKYLQEVSSFIKTINAVRSLLDNKNKAKLASGLPKLSFEVAIRSVNLIQFVYYLSYNTGNSKKIFKDKVTINLSFRTNKFYKEKKLYVKLSLKENLHSKNLKHRKLFELVFKAIGSFKVPDELSFIRLNSDFLIDGDSLEPLMVDITDCFIHYMNETN
Length1089
PositionTail
OrganismPichia sorbitophila (strain ATCC MYA-4447 / BCRC 22081 / CBS 7064 / NBRC 10061 / NRRL Y-12695) (Hybrid yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Millerozyma.
Aromaticity0.10
Grand average of hydropathy-0.321
Instability index35.29
Isoelectric point8.27
Molecular weight125131.07
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28664
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     128.67|      41|      56|     652|     698|       1
---------------------------------------------------------------------------
  652-  698 (61.20/52.44)	IKSIKGEWKIQWVRNL...GVtedsNQVADiTLnYDFFFSLSNTCSNMIL
  711-  754 (67.47/39.52)	IHFIKSDSRDKWLQALdkhGL....NNVSG.TL.FDEQTSDSTYESMIIL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.81|      26|      27|     524|     549|       2
---------------------------------------------------------------------------
  524-  549 (48.39/27.90)	YFTDPSPIQN..QAIKQMNFPSYNNNRG
  552-  579 (40.42/22.19)	FFTEADMIDYcvSSLVQLRLHMYGKEIG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.83|      14|      15|     996|    1009|       4
---------------------------------------------------------------------------
  996- 1009 (22.63/14.56)	FKD.KVTINLSFRTN
 1012- 1026 (17.20/ 9.07)	YKEkKLYVKLSLKEN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     256.92|      88|     432|     395|     489|       5
---------------------------------------------------------------------------
  395-  488 (135.28/98.24)	IDKNYHLNYRWFkNGVYDTTNKFS.....ISFGRSSQSEVTSgDTLDAQDHDLPDDVaedaGDEIIDL..NIDTI.LTSVASKHAE..IVMDHLFEKLKGNLAS
  828-  925 (121.64/72.03)	INDNYALENNLL.GGIFLHLERLSklikiLHQLHSNNSKVIE.NTINSIEVEFPNDL....RSVTITLpeDQDSIkLASRADESSEqkLIIDNINRYLEANKAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.75|      15|      15|     118|     132|       6
---------------------------------------------------------------------------
  118-  132 (27.51/16.72)	SMRQDFVKIYTLVKW
  134-  148 (25.24/14.75)	SVSKDVSKLIDLLNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     171.98|      34|     432|     166|     199|       7
---------------------------------------------------------------------------
  166-  199 (59.14/39.82)	LNRYSGAKL...........PNSDIITALDVFIKKRP...QLPSYNFI
  260-  284 (32.36/17.91)	....................PNDLIIDSVDDYSRSPF...YFIDFKFL
  287-  311 (31.73/17.40)	IN..................PDNTLISH.....KKNKiatSLPRSSFI
  595-  634 (48.75/31.32)	LNEYETAKLfnysvnqlvgnPNSTLI.....YFYRCK...NWPSSWFL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.69|      10|      15|     329|     338|       9
---------------------------------------------------------------------------
  329-  338 (18.59/11.80)	LYDLLHRYAI
  345-  354 (17.10/10.23)	LYKQLKDLAI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28664 with Med14 domain of Kingdom Fungi
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