Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MGTLHNESTIPSYYYYVDPSGPAYEAEQPNPLDDLISVYGLQDISRQVARTNPDGTKAVKLRKSYKNQIQDLSGKFSVIPSRENGRGGEVTPIVFQPINTDMVPQMRKENGKFSQEEWRTMFMNRDHALFEQPMMDWEMCAKVISQFERSYTGEFKNQGFEVDDLAFDLDGSGSNTNGVGGSGGSGGASKSKKRKSKSNGSSMATPNSDIQDDIKRRRLE |
Length | 220 |
Position | Head |
Organism | Eremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582) (Yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.868 |
Instability index | 31.40 |
Isoelectric point | 5.83 |
Molecular weight | 24572.02 |
Publications |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coactivator activity GO:0003713 IEA:EnsemblFungi |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi RNA polymerase II preinitiation complex assembly GO:0051123 IEA:EnsemblFungi transcription open complex formation at RNA polymerase II promoter GO:0001113 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP28662 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 37.13| 10| 34| 68| 77| 2 --------------------------------------------------------------------------- 68- 77 (18.12/11.87) QIQDLSGKFS 105- 114 (19.02/12.78) QMRKENGKFS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) PAYEA 2) SGGASKSKKRKSKSNGSSMATPNSDIQDDIKRRRL 3) TIPSYYYYVDPS | 22 185 9 | 26 219 20 |
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