<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28658

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDILDTSFRLEDVLTSYYRVEKVARINYQQFVPRTSDDQWCIQSELLLRKRDPKVLVALFSRELWCFSINDDKLPVPGAEGASEPSNSEKKGNFTPDFSKPNLPTPYAIFLKALRRMIHINMCLNSRNKLIPFGNSCIFQQNDKSSKMIHFDSHLFENGDLTVSFCTKDLNFQKLTPESFNSPRLSQKALYIAPSGIRAYLPSGDINNCLAAPPKNSNLLLVTLLVSHGIDLTQAADVKWVKLLPNLNHLNGYTPTISRYSEEAQTSKPVIWPMELCFTQSPADSVNYSRNKTPVDVNLQESFDIIDDFIQLKLTSAYRIPGSSVNANTATGNNPMSTGGGFIDQFQTFTKQPNSSGGNNVTSSFKNKLTPNKLQDSSRTGPPFSNDTFSNGFMTTPNVNENIASMMDDMIICPSSVKSQNDLWNDRKSSNDENGSLNTESQQPDLVQPVQKAVDEDIEMSFDKDLFGEEDDEGDLFGEESGNSNGKKEIKDITDEMFDIAEVESDSDNKITPSRSSMCYETIQQTPLKRKYLDIPLDQITLPNTPLYMDPGAPLPIETPKDRRKSVFAPLNFNPIIESNVDNKYKNGGKFSFDPNEIEEPLKFEVSTTNISSSEEDDSELSGDDFDDLQPNNMHEIRSMEPNIPVLSYDIPPRPMNEFLPSDTTKDDYLIPSYQNSDVIDIDKLPSRESQLDQIWKSPEINREDSPNRLGISSILKPPLANGVNIDSESQNPETGNYFEPTPTVCADEKITTRIPYKDLKQENATDSTIISAVGDYSLISKDPRESSNSLPYLLRHMPLFSIPDVFLSTTPSVKVDDGLEDFLEILCDQLIFDQCLLGDFGVSNPLYRDVKHCQDGVVKDTLKSVFNQFQRLHGNEIIDEMFYLKQPSVYVKKNDEAIKLKSDAEPFTPFLALKPSRGMKNFRALFLSTAVTSARKSFLSELAQIYSGQELGFCELVKLNNDEHNGLITLNNFNIDTLLLLSAQIVSYCSTNMINLKNVPLMIFFPVIGSSLEDTINMTSKFQLIKNEVKSRLPDVELLLKLIPIDFVKDPLVSITSYYELCCSIYNSLPPKTVKFTSIADNFPEKVEFRTSAGSQNQLIHYDSYIHLAYIRSIDREWLSAAWSDSKGTENMVKAWYLGNSKTRFENACNEMWKITVGLASRKYGRICLILTRMDSVLPDDELMHWRRLSVTTRNLHLAVVCVGDNTKVSLFDEDKFYPSFKPLMRDKKNFRKLQPNRLDDYEIVNIDEELHGIIFKSPLQLANSQHRCAIKSGALVRFKPSPIDETMNKFEVNLLNCPHSDSTKLLKIILHQFRDLASLNSWFCISKGKDNYIPWQVVAVKKVMNFLVHVKGVKDKK
Length1359
PositionKinase
OrganismEremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582) (Yeast)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Eremothecium.
Aromaticity0.09
Grand average of hydropathy-0.434
Instability index40.42
Isoelectric point5.15
Molecular weight153825.51
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
transcription coactivator activity	GO:0003713	IEA:EnsemblFungi

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28658
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.70|      25|      35|     576|     600|       1
---------------------------------------------------------------------------
  576-  600 (43.96/27.51)	IIESNVDNKYKNGGKF.SFDPNEIEE
  611-  636 (39.73/24.07)	ISSSEEDDSELSGDDFdDLQPNNMHE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.60|      19|      35|    1206|    1240|       2
---------------------------------------------------------------------------
 1206- 1224 (34.64/ 8.19)	DNTKVSLFDEDKFYPSFK.P
 1241- 1260 (27.96/29.97)	DDYEIVNIDEELHGIIFKsP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.74|      18|      33|     116|     133|       3
---------------------------------------------------------------------------
  116-  133 (34.16/18.95)	RMIHINMCLNSRNKL.IPF
  147-  165 (28.58/14.76)	KMIHFDSHLFENGDLtVSF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.45|      27|      33|     309|     336|       4
---------------------------------------------------------------------------
  309-  336 (42.86/31.92)	FIQlKLTSAYRIPGSSVNAN.TATGNNPM
  342-  369 (43.58/27.63)	FID.QFQTFTKQPNSSGGNNvTSSFKNKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.25|      31|      35|    1002|    1035|       5
---------------------------------------------------------------------------
 1002- 1035 (43.27/32.57)	LMI.FFPVigSSLED.TINMTSKFQLIKNeVKSRLP
 1039- 1071 (44.97/23.79)	LLLkLIPI..DFVKDpLVSITSYYELCCS.IYNSLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.41|      28|      39|     431|     458|       6
---------------------------------------------------------------------------
  386-  411 (36.65/20.32)	NDtfSNGFMTT....PNVNENIASMMDD..MI
  431-  458 (46.36/27.74)	ND..ENGSLNTESQQPDLVQPVQKAVDE..DI
  471-  500 (39.39/22.41)	DD..EGDLFGEESGNSNGKKEIKDITDEmfDI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.93|      31|     438|     863|     900|       7
---------------------------------------------------------------------------
  835-  870 (44.17/29.31)	QCLLGD......FGVSNP.LYrdVKHcQDGVVKdtLKS...VFNQF
  871-  911 (42.76/47.86)	QRLHGNeiidemFYLKQPsVY..VKK.NDEAIK..LKSdaePFTPF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.30|      20|     152|     637|     670|      11
---------------------------------------------------------------------------
  543-  562 (42.57/17.64)	PNTP.LYMD.PGAP....LPIETPKD
  642-  667 (27.73/30.84)	PNIPvLSYDiPPRPmnefLPSDTTKD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28658 with Med13 domain of Kingdom Fungi
Unable to open file!