<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28643
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MTTAVKESKLFRRDFDTSKPSTMTKASGISAEVSQGQQHQRIITPVKEAPPPLPHVDFNQLPLAVIIRNLTVYAVKELSLYMKTNVHSTEDPTTRKMGFLKLIIFLRNQFLRIYVLIKWCKTIKQNNFHTMIDLLNWFRGTNVIVNNCLLALKDTSTNMAGAKLPNPDLITALEVLMLGRPNLPTHDFVLNGDDSSNQSEKIPAKLILKRLRDLNTCLSIKISLMDLPPEFHSYSIKNGRITFVVSSEFEISLSTIDQDSPLFFVNIKFLFNDNRFPLNTTNIERIINDILFRSQSPLLSLYQFIHKYVLTLQLYMIHVELQDMETNGKYAAGNLLHHYDSKKNMITLRYWLQSKMNSKCKATIGVERETQSIILKWQTPDIKGEMTSTKYNNLLGNMEAILDEITFNHARIIRSELLVTGLFQNDESKSDDSDSLLFHVPVICVATAPVQLKINPISGIFYFRNPSSLLLSYAKLLNQTSNLEEFTNILERLRMDKIVHILRNMFEKTGWICKDVVKLNKPILYEKRIKDQKKILTRDLFIRLKDWPANWFFILSLVSSGATCMVEKIIGKVKSIKGNWELKYLDQGKVQVVKLESITYQNVMHMQKTIIQKILNHMIIDSLNELKISKAICQGDGLQKLPYYVEDGVSNVSNVSIIAIALESFLQGSKALSDTLENTMFLRMDYEQNEIKLFGKFKKDTQMIRCQCDELLVNFIDKKGLAFHMSEKFTNLSHVVQYLNRFRQKLMQLVILTDVTEKLHRNFKSEYFQIVKLKPNEISFKYLKNSKDEQDCTIQIVTNDTKIEKLQVELSRLNPQHIIQKYLECDKYDPHFIFNYLHFTSRLFSAFTKILESSSNTMNVTLHLHTLAGYQLNYHNRLTGGQVALSIDLRNFPHKSGSLYYVHFAHDDHISTKNPMYALVLQVINTIFILSNGGKKTIPNAIRLGVGVACTSNDIEPLLGEIHSVLTHY |
Length | 969 |
Position | Tail |
Organism | Eremothecium cymbalariae (strain CBS 270.75 / DBVPG 7215 / KCTC 17166 / NRRL Y-17582) (Yeast) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Eremothecium.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.154 |
Instability index | 35.95 |
Isoelectric point | 9.14 |
Molecular weight | 111595.53 |
Publications | |
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi
TFIIB-class transcription factor binding GO:0001093 IEA:EnsemblFungi
transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP28643
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 47.19| 13| 15| 261| 273| 1
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261- 273 (24.52/16.20) PLFFVNIKFLFND
277- 289 (22.67/14.39) PLNTTNIERIIND
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 136.76| 43| 192| 109| 159| 2
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109- 159 (59.66/64.25) QFLRIYVLikwckTIKQNNFHtmIDLLNWFRGTNVIVNNcLLALKDTSTNM
303- 345 (77.10/51.48) QFIHKYVL.....TLQLYMIH..VELQDMETNGKYAAGN.LLHHYDSKKNM
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 94.73| 32| 192| 373| 408| 3
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373- 408 (43.60/48.64) IILKWQTpdIKGEMtSTKYNNlLGNMEAI.LDEITFN
569- 601 (51.14/36.49) IIGKVKS..IKGNW.ELKYLD.QGKVQVVkLESITYQ
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 368.81| 122| 186| 607| 740| 4
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607- 740 (182.81/149.96) QKTIIQKILNHMIIDSLnELKISKAICQgDGLQKL.......PYYVEDGVSNVSNvsiIAIALESFLQGSkalSDTLENTMFLR..MDYEQN.EIKLFG...KFKKDTQMIRCQCDEL.LVNFIDKKglafHMSEKFTNLSHVVQYLN
790- 925 (186.00/120.49) QDCTIQIVTNDTKIEKL.QVELSRLNPQ.HIIQKYlecdkydPHFIFNYLHFTSR...LFSAFTKILESS...SNTMNVTLHLHtlAGYQLNyHNRLTGgqvALSIDLRNFPHKSGSLyYVHFAHDD....HISTKNPMYALVLQVIN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.37| 15| 317| 450| 465| 5
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450- 465 (24.03/22.18) VQLKINPISgIFYFRN
771- 785 (27.34/18.90) VKLKPNEIS.FKYLKN
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