<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28638
Description |
Mediator of RNA polymerase II transcription subunit 14 |
Sequence | MPDVVEHTAPPLPHVEINQAPLSMVIRNLTVFTIKELSQFIKTNVHVNTNSQEPSSARKINFLQLVIFLRNQFLKLYVLIKWCRTIKGNNFHVLIDLLNWFRTANMTVNNCIWALKNNLITMTNAKLPNADLTTALEVLSLGRPNLPTHNFKMSGEDSSTVLENGALKIPPKLILRRLYDLNLNISIKLSMMDIPPQMKNYRIKDGRVFITVLDEFEIQLATIDSQHPLFFVDLTLLLNNQYLHLNKPRFEKVINDLLHKTEEPLYELYIFLHKYVVTLKLYLIHIELTSLESNGKFFGGNLVHRYDAKKSVITVRYWLNARMGNKGKITIGIDKESNNLVLRWNNEIARGINALPVVYTNILSNIENILDEVMFNHSHLIRAELLSNGIFQEDEENSDVLLFQIPTTCISVAPVQLKIDLISGIFYFKNSTTLLQSYAQQINKSDSIKELTLVLQRLRLDKITYILQNMFEKTGWVCSKVVELEKPIKSHVNTNRSKDNSFNLLQKDIFISLPNWPTHWYLIITVVSSKTSCIIEKRISKILAVKGKWELKYLEDSSVTANLETITYQKIMNLQRTILHKIINHMLIDSLNQLKIKNKICSSSAISSQLPKYVVDDQSIKEGSIFQSTSQKQNSLGYISVIALELTSFLDNSDTAGQIFESSLLLKIDYGKSQIKLFGKFVIDTMMTKFEPENLNINFIKDDPKAFYLDATFMNMNNIVQYLSKFKNNLMQLVSLTDVVERLRKNFESEHFKILNLQPNEVAFKYFEKSTNEPDCTIKIISNDEVIENLQVQLSPSSPQYIIQKFLDDSHMHFHFIFNYLQFTSSLFTSLDLIQNEKKSGLYQNFTKVTVGLHNLNEYQLMYHNPEAGTKISITIELKIVSHNGQKKIQYYVHFSEDNISTKSLAYPLVHKIRQQVFILDKESKDTTLHKNTVRLVNGIACDATSIEAVLLEIHGILKKDSNISDSGTNITAANLDLGATENADTLKIQNQNTITV |
Length | 997 |
Position | Tail |
Organism | Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Tetrapisispora.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.129 |
Instability index | 34.88 |
Isoelectric point | 8.57 |
Molecular weight | 114443.00 |
Publications | PubMed=22123960
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU365082
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:UniProtKB-UniRule
|
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi
TFIIB-class transcription factor binding GO:0001093 IEA:EnsemblFungi
transcription coregulator activity GO:0003712 IEA:UniProtKB-UniRule
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP28638
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 196.21| 50| 202| 19| 79| 1
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26- 79 (78.13/71.44) IRNLTVFtIKELSQFIKTNVHVNT.NSQEPSSarkINFLQLVIF..LRNQFLKLYVL
203- 245 (59.61/31.16) IKDGRVF.ITVLDEF...EIQLATiDSQHP.....LFFVDLTLL..LNNQYLHL...
483- 523 (58.46/32.97) ..........ELEKPIKS..HVNT.NRSKDNS...FNLLQKDIFisLPNWPTHWYLI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
3| 178.81| 44| 94| 693| 736| 2
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693- 736 (72.41/49.32) ENLNINFIKDDPKAF.....YLDATFMNMNNIVQYLSKFKNNLMQLVSL
750- 787 (45.15/27.57) EHFKILNLQPNEVAF....kYFEKSTNEPDCTIKIIS..NDEVI.....
788- 833 (61.25/40.42) ENLQVQLSPSSPQ..yiiqkFLDDSHMHFHFIFNYL.QFTSSLFTSLDL
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 456.78| 149| 585| 250| 412| 5
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250- 412 (215.35/198.42) FEKVINDLlHKTEEplYELyiFLHKYVVTLKLYlIHIELTSLESNGKFFGGNLVHRYDAKKSVITVRYWLNARMgnKGKITIgIDKESNNLVLRWNN.EIARGINALPVVYTNILSNIENIL..DEVMFNHSHLIRAELLSNGIfqedEENSDVLLFQIPTTcISV
846- 997 (241.43/168.79) FTKVTVGL.HNLNE..YQL..MYHNPEAGTKIS.ITIELKIVSHNGQKKIQYYVHFSEDNISTKSLAYPLVHKI..RQQVFI.LDKESKDTTLHKNTvRLVNGIACDATSIEAVLLEIHGILkkDSNISDSGTNITAANLDLGA....TENADTLKIQNQNT.ITV
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