<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28638

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMPDVVEHTAPPLPHVEINQAPLSMVIRNLTVFTIKELSQFIKTNVHVNTNSQEPSSARKINFLQLVIFLRNQFLKLYVLIKWCRTIKGNNFHVLIDLLNWFRTANMTVNNCIWALKNNLITMTNAKLPNADLTTALEVLSLGRPNLPTHNFKMSGEDSSTVLENGALKIPPKLILRRLYDLNLNISIKLSMMDIPPQMKNYRIKDGRVFITVLDEFEIQLATIDSQHPLFFVDLTLLLNNQYLHLNKPRFEKVINDLLHKTEEPLYELYIFLHKYVVTLKLYLIHIELTSLESNGKFFGGNLVHRYDAKKSVITVRYWLNARMGNKGKITIGIDKESNNLVLRWNNEIARGINALPVVYTNILSNIENILDEVMFNHSHLIRAELLSNGIFQEDEENSDVLLFQIPTTCISVAPVQLKIDLISGIFYFKNSTTLLQSYAQQINKSDSIKELTLVLQRLRLDKITYILQNMFEKTGWVCSKVVELEKPIKSHVNTNRSKDNSFNLLQKDIFISLPNWPTHWYLIITVVSSKTSCIIEKRISKILAVKGKWELKYLEDSSVTANLETITYQKIMNLQRTILHKIINHMLIDSLNQLKIKNKICSSSAISSQLPKYVVDDQSIKEGSIFQSTSQKQNSLGYISVIALELTSFLDNSDTAGQIFESSLLLKIDYGKSQIKLFGKFVIDTMMTKFEPENLNINFIKDDPKAFYLDATFMNMNNIVQYLSKFKNNLMQLVSLTDVVERLRKNFESEHFKILNLQPNEVAFKYFEKSTNEPDCTIKIISNDEVIENLQVQLSPSSPQYIIQKFLDDSHMHFHFIFNYLQFTSSLFTSLDLIQNEKKSGLYQNFTKVTVGLHNLNEYQLMYHNPEAGTKISITIELKIVSHNGQKKIQYYVHFSEDNISTKSLAYPLVHKIRQQVFILDKESKDTTLHKNTVRLVNGIACDATSIEAVLLEIHGILKKDSNISDSGTNITAANLDLGATENADTLKIQNQNTITV
Length997
PositionTail
OrganismTetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Tetrapisispora.
Aromaticity0.09
Grand average of hydropathy-0.129
Instability index34.88
Isoelectric point8.57
Molecular weight114443.00
Publications
PubMed=22123960

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IEA:EnsemblFungi
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
RNA polymerase II repressing transcription factor binding	GO:0001103	IEA:EnsemblFungi
TFIIB-class transcription factor binding	GO:0001093	IEA:EnsemblFungi
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II	GO:0045944	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28638
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     196.21|      50|     202|      19|      79|       1
---------------------------------------------------------------------------
   26-   79 (78.13/71.44)	IRNLTVFtIKELSQFIKTNVHVNT.NSQEPSSarkINFLQLVIF..LRNQFLKLYVL
  203-  245 (59.61/31.16)	IKDGRVF.ITVLDEF...EIQLATiDSQHP.....LFFVDLTLL..LNNQYLHL...
  483-  523 (58.46/32.97)	..........ELEKPIKS..HVNT.NRSKDNS...FNLLQKDIFisLPNWPTHWYLI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     178.81|      44|      94|     693|     736|       2
---------------------------------------------------------------------------
  693-  736 (72.41/49.32)	ENLNINFIKDDPKAF.....YLDATFMNMNNIVQYLSKFKNNLMQLVSL
  750-  787 (45.15/27.57)	EHFKILNLQPNEVAF....kYFEKSTNEPDCTIKIIS..NDEVI.....
  788-  833 (61.25/40.42)	ENLQVQLSPSSPQ..yiiqkFLDDSHMHFHFIFNYL.QFTSSLFTSLDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     456.78|     149|     585|     250|     412|       5
---------------------------------------------------------------------------
  250-  412 (215.35/198.42)	FEKVINDLlHKTEEplYELyiFLHKYVVTLKLYlIHIELTSLESNGKFFGGNLVHRYDAKKSVITVRYWLNARMgnKGKITIgIDKESNNLVLRWNN.EIARGINALPVVYTNILSNIENIL..DEVMFNHSHLIRAELLSNGIfqedEENSDVLLFQIPTTcISV
  846-  997 (241.43/168.79)	FTKVTVGL.HNLNE..YQL..MYHNPEAGTKIS.ITIELKIVSHNGQKKIQYYVHFSEDNISTKSLAYPLVHKI..RQQVFI.LDKESKDTTLHKNTvRLVNGIACDATSIEAVLLEIHGILkkDSNISDSGTNITAANLDLGA....TENADTLKIQNQNT.ITV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28638 with Med14 domain of Kingdom Fungi
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