<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28636
Description |
Mediator of RNA polymerase II transcription subunit 1 |
Sequence | MASEDVYLSKLNEIIELFQNYKPGRINLDNITKLCQTLGLESFIDDIDTNISRLSTASKIIVVDIDFDKSLGKVKDVKLVLASNFDNFNYFTDKSLLLNSVNGTNNTNLKEEQTENNILLNSLTNYADLNEFYQNLKYIYLLDTYSCIDLDSNQAKSKSSGNTTVINSGDIISTTNYAVSATDNVSSLQISSTGNMKPNSSPNANANLDVNNAHTATSPVPAQNIDKNDCKLDLFKYYTELADYVRNYFISNNSDFTVITNLRDIFGIYIIWNDDFKNPIARIYLEKSKESKNRLFEFVYLPGDDKWSNEDFEKYTIGVSLVMEIMGETENQTGKHNSIWFPKESISDDLILQSSFTDIIKENIDSNDNNMLNILFKNIQSDNNLSINDYLIFSGKCRLVNDFTTSLINISKFDIGNDHLDLMLEILNWIKWSKMVLTPVFEIISRDNNGSTDDFSSYEKANDSNIDENINLQKLKMKTIRSTRRRSSSLAKRPSIVEASILKDEGLQQFNLHEIMSQPVIEDEKIDGLDYVEESASENPLHNDSNENANEDIEMEDAQGMDFNTEPMLKIENNNKKIIKS |
Length | 581 |
Position | Middle |
Organism | Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Saccharomycetaceae> Tetrapisispora.
|
Aromaticity | 0.09 |
Grand average of hydropathy | -0.492 |
Instability index | 42.32 |
Isoelectric point | 4.53 |
Molecular weight | 66116.93 |
Publications | PubMed=22123960
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364059
|
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi
mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi
positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi
|
Interaction
Repeat regions
Repeats |
>MDP28636
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 60.83| 17| 17| 195| 211| 1
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195- 211 (30.57/20.10) NMKPNSSPNANANLDVN
212- 228 (30.27/19.83) NAHTATSPVPAQNIDKN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 50.50| 16| 17| 38| 53| 2
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28- 43 (25.41/11.65) LDNITKLCQTLGLESF
44- 59 (25.09/11.43) IDDIDTNISRLSTASK
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 53.50| 17| 17| 343| 359| 3
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343- 359 (28.82/15.27) KESI..SDDLILQSSFTDI
361- 379 (24.68/11.98) KENIdsNDNNMLNILFKNI
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 207.13| 65| 142| 245| 315| 4
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245- 315 (101.12/76.46) VRNYFISNN.....SDFTviTNLRDIfGIYIIWND..DFKNPIARiYLEKSKESKNRLFEFVylPGDDKWSNEDFEKY
387- 458 (106.01/60.63) INDYLIFSGkcrlvNDFT..TSLINI.SKFDIGNDhlDLMLEILN.WIKWSKMVLTPVFEII..SRDNNGSTDDFSSY
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 43.40| 14| 17| 76| 89| 5
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76- 89 (24.23/12.26) DVKLVLAS..NFDNFN
93- 108 (19.18/ 8.30) DKSLLLNSvnGTNNTN
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 51.85| 18| 18| 502| 519| 6
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502- 519 (31.60/23.85) LKDEGLQQFN.LHEIMSQ.P
521- 540 (20.26/12.54) IEDEKIDGLDyVEESASEnP
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 42.63| 14| 82| 462| 478| 7
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462- 478 (16.65/17.29) NDSNidENINlQKLKMK
543- 556 (25.99/13.27) NDSN..ENAN.EDIEME
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 39.85| 12| 18| 163| 174| 8
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163- 174 (20.11/13.63) TTVINSGDIIST
182- 193 (19.75/13.24) TDNVSSLQISST
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