Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MSNNYNMHGLNASEFLTKSNAEAFNSTLTPVAVPQSTANNISQGTASNMNTAAVDSLANVAIYNDIKNYEDTLIKLVSSIDNFRPDVEVAKTLIEVDKRLYKNLGSFKEYDEIDTKISKIKDDSEKLDLQTKHILDILNDSRNMLNSLPMLEEIYFERDVMHEKQKKINSKILLDYATKISKFTKIPPTFNKGSIGPNNFIWPAEDALRRGMLAVASIHRSELTKLPNDTSYDSDKELEEQQEQEQHGTENTREADVEQEQEESFVFDGKHKNEEKTENSNEANSNDDNENDNMDLDLELFNPDEF |
Length | 306 |
Position | Middle |
Organism | Tetrapisispora phaffii (strain ATCC 24235 / CBS 4417 / NBRC 1672 / NRRL Y-8282 / UCD 70-5) (Yeast) (Fabospora phaffii) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Saccharomycetaceae> Tetrapisispora. |
Aromaticity | 0.07 |
Grand average of hydropathy | -0.840 |
Instability index | 49.51 |
Isoelectric point | 4.57 |
Molecular weight | 34873.01 |
Publications | PubMed=22123960 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | RNA polymerase II core promoter sequence-specific DNA binding GO:0000979 IEA:EnsemblFungi transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro transcription by RNA polymerase II GO:0006366 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP28624 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 45.37| 15| 15| 113| 127| 1 --------------------------------------------------------------------------- 113- 127 (24.31/14.68) IDTK.ISKIKDDSEKL 129- 144 (21.06/11.85) LQTKhILDILNDSRNM --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) DNMDLDLELFNPDEF 2) EQEESFVFDGK 3) YATKISKFTKI | 292 260 176 | 306 270 186 |
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