<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28615

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMNEAIVNVHLEDVPKTSSLISWSKNGLIAYVSPCKQSKHNLLLTYLESVNGHSWRLAPPQPVEVKLENNFVPELSLLCWSTLSTDLAVSDVYGNFYIFLAGVGMVDSKDSLPSYELTSYNHMEMIYRDVINQNIKSPINPGAFIIAFKWLNIEKPQILNKPASLINLQQSYVYTYGVNQYAPHGVSHPIPTKQACLALRRNGTLMLYYQGEHKVEYHRVSTNLHDKPMMISNASIGFTNDKEILITTYDNLSGEISTYLATIDWGFLVESAKRQKTDPHYHTPKENQNLPTISLTKIHEMKPLPEYKEGNIYPLRCIDIVSASAEKESKASILISYGAVKIYRYEVVNTVETISDAFSELGTKMNALVESTHPKTIELKDTISRNGSIQSIIIGPSDLHCMILYESGYIDVLDTKTWEVINTSNRQFPPRTITTAFEVGFAFPEIKHKDQLVLAVSPNMTSVVYTEVYNETDDLTLKPIEKVRNTGFQPRDLFATSVALAYRHAYACYTNTFTDDLIILIQFEVQRLRSLLFRQMPDKNDSIKLMLKKFLESIISEAHKSINFQLDAFSKESVDKLLSNPPLQKLLSLQLILGEAQGNSVMSDIAWIVLNLRSTNFGIMFSLSSIYRQISKKKPSEDTLQDSIARGECIISLIGNIKWLMDLMAYFNQELLQLSYFRNDTENSKLNLSNSVVLPIILSKVPRLFLMYAISSMGKTHEILKKLHKDLAESNKLFTPMKEALNRYFTICSGAPLTLSLFEQYLRECDALIAKELTTRLASKEKGYSLKIEQKLVCQGELADDVKDIARILVDRYAHNITREMKVSELYFYNTEWLNIGFNKPARSIEDSSIIVYPQVSNKKVVPRLKLDRDIDALRKIYIYDGKIRRCTRCRSVSLVSDPLVFESPTAIGLWTMVFQRTCICGNTWVNI
Length927
PositionTail
OrganismCandida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.149
Instability index39.81
Isoelectric point7.79
Molecular weight105490.47
Publications
PubMed=19465905
PubMed=22192698

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28615
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.52|      47|      55|     559|     607|       1
---------------------------------------------------------------------------
  559-  607 (69.35/51.24)	KSINFQLdAFSKESVDKLLS.NPPLQKLLSLQLILGEAQgNSVMSDIAWI
  612-  659 (77.17/47.56)	RSTNFGI.MFSLSSIYRQISkKKPSEDTLQDSIARGECI.ISLIGNIKWL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.76|      17|      54|       6|      23|       2
---------------------------------------------------------------------------
    6-   23 (28.09/24.28)	VNVHLED..VPKTsSLISWS
   62-   80 (27.67/18.20)	VEVKLENnfVPEL.SLLCWS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.60|      44|      55|     217|     271|       4
---------------------------------------------------------------------------
  217-  263 (66.58/64.76)	HRVSTNLH.DKPMMISN.ASIGFTNDKEI.LITTYDNlsGEISTyLATID
  272-  318 (69.01/38.23)	KRQKTDPHyHTPKENQNlPTISLTKIHEMkPLPEYKE..GNIYP.LRCID
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     135.70|      42|      59|     402|     447|       5
---------------------------------------------------------------------------
  402-  447 (64.50/43.91)	ILYESGYIDVLDTKTWEVINTSNRQFPPRTItTAFEVGFAFpeiKH
  462-  503 (71.21/37.53)	VVYTEVYNETDDLTLKPIEKVRNTGFQPRDL.FATSVALAY...RH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.82|      22|     215|     108|     131|       8
---------------------------------------------------------------------------
  108-  131 (33.31/31.06)	KDSLPSYeLTSYNHMEmIYR.DVIN
  326-  348 (33.51/20.68)	KESKASI.LISYGAVK.IYRyEVVN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     167.56|      52|     680|     148|     211|       9
---------------------------------------------------------------------------
  148-  211 (76.08/84.33)	KWLNIEkpqiLNKPASLINlqQSYVYTYgvNQYAPHGVSHPIPTKQACLALRRngtlMLYYQGE
  831-  882 (91.48/63.00)	EWLNIG....FNKPARSIE..DSSIIVY..PQVSNKKVVPRLKLDRDIDALRK....IYIYDGK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28615 with Med16 domain of Kingdom Fungi
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