<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28604

Description Uncharacterized protein
SequenceMNSTQKQQSDGQTLRDKPQQRTNQSQHLHPSAQYRQHDVGQSYSQALTNTLPANNPFAPPTYQNSKNNYASSHQSNQQLPTVPQPALMASSSILTLGPFKHRKDMTRDSVLSTYQILGYIAAGTYGKVYKAKLRTNANNTKDGEERGKFGVIHGGLADGGNGVGPNDGDRIGKANANDHINETDSKEGSVPPDENSLESSGPVIQYYAIKKFKSDNHQSSNSKNNTAGNGSKNFNREIANEAAQYTGISQSAIREMSLCRELNNKNITKLTDIILENKSIYMIFEFCEHDLLQIIHYHSHPELKPIPLPTIKSLIWQILNGVTFLHKNWIFHRDLKPANIMVTSNGCVKIGDLGLARKFNNPLQSLYTGDKVVVTIWYRAPELLLGTRHYTPAIDLWAVGCILAELLSLRPIFKGEEAKIDINNKKSVPFQRNQFQKIIEVMGTPNLKNWPSLNKYPEFVSFTQQITQTYSSNLSQWYKMIGGENKQCLELLYGLLKYDPEVRLTADQALVHNFFLELPKVTENAFEGLNLKYPNRKIYVDDSDIGQNGGNNAGFKRNIGFDEGANKRKRV
Length571
PositionKinase
OrganismCandida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.636
Instability index39.83
Isoelectric point9.14
Molecular weight64131.53
Publications
PubMed=19465905
PubMed=22192698

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:EnsemblFungi

GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IEA:EnsemblFungi
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IEA:EnsemblFungi

GO - Biological Process
negative regulation of filamentous growth	GO:0060258	IEA:EnsemblFungi
negative regulation of transcription by RNA polymerase II	GO:0000122	IEA:EnsemblFungi
nuclear-transcribed mRNA catabolic process, non-stop decay	GO:0070481	IEA:EnsemblFungi
phosphorylation of RNA polymerase II C-terminal domain	GO:0070816	IEA:EnsemblFungi
positive regulation of transcription from RNA polymerase II promoter by galactose	GO:0000435	IEA:EnsemblFungi
protein destabilization	GO:0031648	IEA:EnsemblFungi
response to oxidative stress	GO:0006979	IEA:EnsemblFungi









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28604
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     220.90|      67|     143|     244|     318|       1
---------------------------------------------------------------------------
  244-  314 (111.20/85.04)	QYTGISQSAIREMSLCRELNNknitKLTDIILENKSIYMIFEFCEHDLLQIIHYHSHPELKPIP..LPTIKSL
  341-  409 (109.70/65.33)	MVTSNGCVKIGDLGLARKFNN....PLQSLYTGDKVVVTIWYRAPELLLGTRHYTPAIDLWAVGciLAELLSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.19|      23|      24|     125|     148|       2
---------------------------------------------------------------------------
  125-  148 (35.95/22.82)	YGkVYKAKLRTNANNT..KDGEERGK
  149-  173 (37.24/19.56)	FG.VIHGGLADGGNGVgpNDGDRIGK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.03|      31|     143|      49|      81|       3
---------------------------------------------------------------------------
   49-   79 (58.95/37.26)	NTLPANNP.........FAPPTYQ..NSKNNYA..SSHQSNQQL
  195-  238 (39.08/16.93)	NSLESSGPviqyyaikkFKSDNHQssNSKNNTAgnGSKNFNREI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.88|      10|      26|       3|      12|       5
---------------------------------------------------------------------------
    3-   12 (18.99/10.95)	STQKQQSD.GQ
   31-   41 (15.89/ 8.12)	SAQYRQHDvGQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.13|      16|      24|     435|     450|       7
---------------------------------------------------------------------------
  435-  450 (29.80/19.09)	FQKIIEVMGTPNLKNW
  462-  477 (29.33/18.68)	FTQQITQTYSSNLSQW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28604 with CDK8 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AKLRTNANNTKDGEERGKFGVIHGGLADGGNGVGPNDGDRIGKANANDHINETDSKEGSVPPDENSL
2) MNSTQKQQSDGQTLRDKPQQRTNQSQHLHPSAQYRQHDVGQSYSQALTNTLPANNPFAPPTYQNSKNNYASSHQSNQQLPTVPQPALMASSSILTLGPFKHR
131
1
197
102










Molecular Recognition Features






MoRF SequenceStartStop




1) VIQYYAIKKFK
203
213