<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28600

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGQPQNGTIAEPQNGKMDFISTTKQDHEHPPSIPHITANLIPLSNILKFYAQESYKQLTTAIENLSTNADEESDVKRKKYFLDIIVSLRQDLLKVYTLIKWASVSQDVSKFIDLLNWFRLQDFQFDRLTHQLAGLSGFGGAKLPNFDIETALEVFYKKRPLLPSHNYIQQPKISSRKILEVLKDLNLALMTKFAMIDVPTQFQFEIKDGRAYIDVPKEFQVRITMANDDLSTDNPFYMIGFEFLFGIDQNETLVTLGGNDSIATKLPTQSYVRLEKIANRVLSVSGLHGLYELLHKYAISFKLYLVSKQIRGLLNTLKWKNNLQIKYAMGSSLIIVNYWSSHFLNSSWKSFLEIGIDRKFNLSYRWFRNGQYENSEIVEKIIRNRGEDEEDEADEADGSDDEDSLFKEENDLTSPRDEDDPVQSVHIESIISSFMIAHSASIMKSIHKLLRTRITGDIEMVNSHRIMFSISPKKSAVLAINPLTGLFYFVNPTPIQNRLLKRINSPPSTASLMKQQQQQLQQKQQQQQVVTENGFIESVVVVLQQLMLETFTKEVNNYLSTTEWIHNSIIKLNEGEVNNLLKSIDRNNTRDQITVQFYRRKHWPSTWFLIVMVNGLSASTAWWVARIKSVDASWVVSYLQNLVYNPTLDYPFFKNLGKSTFKKIINHVILDELRANGIEYHHVLSDEEQSGGVDDTGKEMRSELAELGLAESMSNGSNNVGENGSNNSVTVIYQSIIKLQNTNLIPVENSSSHFYLQVQLINQDNTNKMNLNLFGKLKNLSIKNSPELAKFNLKIDHDKQNLEIATSVDLNSIINESSHRHNQKQGFLNPIFNNLNNLNNLLRIFDQLNNNNIEILDNAMDSMVIRVNDIVDKLLIQLPQNPKDAIQISTVETKPWEIEIIIHFLNRYLQSSKSTNIVGVIHYLDEFDPIYRAVKQVQSLLNEQEGGGANGTSSSTNSKSDDLKLSNGLHKIYFDAIFKNLNSIQFMFNLSSTVANSRKIHKDKILISLSFKRNKFNRLNKDGNNSQNLIKVSLKNNLNSKNVKFKHLFELMFKSISEMERNERDEIINLQENHLLIKLNYDFLISCNVIEEMMGRITKCFIQYLTEESK
Length1110
PositionTail
OrganismCandida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.09
Grand average of hydropathy-0.374
Instability index40.75
Isoelectric point6.56
Molecular weight127479.61
Publications
PubMed=19465905
PubMed=22192698

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28600
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.57|      24|      27|     296|     320|       1
---------------------------------------------------------------------------
  296-  320 (37.75/30.91)	KYAISFKLYLVSKQIRGLLNTlKWK
  326-  349 (43.82/30.86)	KYAMGSSLIIVNYWSSHFLNS.SWK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     130.95|      46|     549|     389|     448|       2
---------------------------------------------------------------------------
  389-  448 (66.55/60.57)	EEDEADEADG........SDDedslFKEENDLtsprdeddpvQSVHIESIISS.....FMIAHSASIMKS..IHK
  942- 1002 (64.40/33.95)	NEQEGGGANGtssstnskSDD....LKLSNGL..........HKIYFDAIFKNlnsiqFMFNLSSTVANSrkIHK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.93|      20|      26|     718|     743|       3
---------------------------------------------------------------------------
  722-  743 (29.82/27.64)	ENGSnnSVTVIYQSIIKLQNTN
  748-  767 (35.11/15.49)	ENSS..SHFYLQVQLINQDNTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.97|      11|      27|    1009|    1019|       4
---------------------------------------------------------------------------
 1009- 1019 (19.95/10.52)	LSFKRNKFNRL
 1038- 1048 (19.03/ 9.70)	LNSKNVKFKHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      39.22|      11|      27|     687|     697|       5
---------------------------------------------------------------------------
  687-  697 (19.55/12.78)	EEQSGGVDDTG
  711-  721 (19.67/12.91)	ESMSNGSNNVG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.88|      13|      15|     194|     206|       6
---------------------------------------------------------------------------
  194-  206 (25.73/15.47)	AMIDVPTQFQFEI
  211-  223 (23.15/13.20)	AYIDVPKEFQVRI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.37|      19|      26|     833|     858|       7
---------------------------------------------------------------------------
  554-  572 (32.05/ 6.81)	EVNNYLSTTEWIHNSIIKL
  837-  855 (31.32/21.01)	NLNNLLRIFDQLNNNNIEI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.28|      15|      15|      87|     101|       9
---------------------------------------------------------------------------
   87-  101 (26.50/20.40)	SLRQDLLKVYTLIKW
  103-  117 (26.78/20.71)	SVSQDVSKFIDLLNW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.85|      25|     284|     362|     386|      10
---------------------------------------------------------------------------
  362-  386 (45.56/28.26)	LSYRWFRN.GQYENSEIVEKII....RNRG
  648-  677 (32.29/17.89)	LDYPFFKNlGKSTFKKIINHVIldelRANG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      54.80|      15|      16|     894|     908|      12
---------------------------------------------------------------------------
  894-  908 (29.03/18.73)	KPWEIEIIIHFLNRY
  913-  927 (25.77/15.80)	KSTNIVGVIHYLDEF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28600 with Med14 domain of Kingdom Fungi
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