<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28595

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSYDSLYLDFDLNDNGHPDPFIKDENDLSLQELIPRILQERKQFVDITEKSLVDEIESLESSKTVDEALDGFDGLNSTVSGALPVSQEESVQEKFNSKKLELTKSINNALNETSLSLDFVSLLVASVKPNIAKNTMSPHLQKLIKPYSLNSDKLAKEEVETLQKDTNRSTKIGHGWKTEATSKIKDLFKEASENLTMQVKKENKYWNMICLVWSNDEALFRLRDPDNNARAIGVKYGYGDSGSDFQDKGLALFRKNVQTGEVSFHPLSTIGNKLVAKTYRYVRVRVLSRIDSDYMLTGQSAFDYNYSKSSHDIINEIEMARFFLFEEDLFYQISREASILFSYNVSVTAEKVSIETENEIVEFENVLYDEANEEELENYYQNVSSMSSINNKKCQLILIYLKLMLCCFYKYNLKLKQKVPTSLTKWKQSNSHPLILRPLLGNMRHNKYLHEVKQILVNLSNHYGLKPTIKLEKYTNLETKSSNPFKRSIEIPNSLFTWTVQNKVDNVLNVTINVTSNEVFVDLIAKLTVTRFDSMDAYLNNMNGVNVLQNDYYDFDDLKESLEWLICDFNSV
Length572
PositionHead
OrganismCandida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes> Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
Aromaticity0.10
Grand average of hydropathy-0.448
Instability index38.59
Isoelectric point5.25
Molecular weight65868.76
Publications
PubMed=19465905
PubMed=22192698

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28595
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.07|      33|      36|     302|     336|       1
---------------------------------------------------------------------------
  302-  336 (53.58/37.17)	FDYNYSKSSHDIinEIEMARFFL.FEEDLFYQISRE
  341-  374 (49.48/28.38)	FSYNVSVTAEKV..SIETENEIVeFENVLYDEANEE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.17|      33|      36|     154|     186|       2
---------------------------------------------------------------------------
  154-  186 (55.40/35.89)	LAKEEVETLQKDTNRSTK....IGHGW.KTEATSKIKD
  187-  224 (46.77/29.26)	LFKEASENLTMQVKKENKywnmICLVWsNDEALFRLRD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      64.93|      22|      38|      49|      70|       3
---------------------------------------------------------------------------
   49-   70 (34.21/19.10)	EKSLVDEIES..LESSKTVDEALD
   88-  111 (30.72/16.50)	EESVQEKFNSkkLELTKSINNALN
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28595 with Med17 domain of Kingdom Fungi
Unable to open file!