<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28595
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSYDSLYLDFDLNDNGHPDPFIKDENDLSLQELIPRILQERKQFVDITEKSLVDEIESLESSKTVDEALDGFDGLNSTVSGALPVSQEESVQEKFNSKKLELTKSINNALNETSLSLDFVSLLVASVKPNIAKNTMSPHLQKLIKPYSLNSDKLAKEEVETLQKDTNRSTKIGHGWKTEATSKIKDLFKEASENLTMQVKKENKYWNMICLVWSNDEALFRLRDPDNNARAIGVKYGYGDSGSDFQDKGLALFRKNVQTGEVSFHPLSTIGNKLVAKTYRYVRVRVLSRIDSDYMLTGQSAFDYNYSKSSHDIINEIEMARFFLFEEDLFYQISREASILFSYNVSVTAEKVSIETENEIVEFENVLYDEANEEELENYYQNVSSMSSINNKKCQLILIYLKLMLCCFYKYNLKLKQKVPTSLTKWKQSNSHPLILRPLLGNMRHNKYLHEVKQILVNLSNHYGLKPTIKLEKYTNLETKSSNPFKRSIEIPNSLFTWTVQNKVDNVLNVTINVTSNEVFVDLIAKLTVTRFDSMDAYLNNMNGVNVLQNDYYDFDDLKESLEWLICDFNSV |
Length | 572 |
Position | Head |
Organism | Candida parapsilosis (strain CDC 317 / ATCC MYA-4646) (Yeast) (Monilia parapsilosis) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Saccharomycotina> Saccharomycetes>
Saccharomycetales> Debaryomycetaceae> Candida/Lodderomyces clade> Candida.
|
Aromaticity | 0.10 |
Grand average of hydropathy | -0.448 |
Instability index | 38.59 |
Isoelectric point | 5.25 |
Molecular weight | 65868.76 |
Publications | PubMed=19465905
PubMed=22192698
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP28595
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 103.07| 33| 36| 302| 336| 1
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302- 336 (53.58/37.17) FDYNYSKSSHDIinEIEMARFFL.FEEDLFYQISRE
341- 374 (49.48/28.38) FSYNVSVTAEKV..SIETENEIVeFENVLYDEANEE
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 102.17| 33| 36| 154| 186| 2
---------------------------------------------------------------------------
154- 186 (55.40/35.89) LAKEEVETLQKDTNRSTK....IGHGW.KTEATSKIKD
187- 224 (46.77/29.26) LFKEASENLTMQVKKENKywnmICLVWsNDEALFRLRD
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 64.93| 22| 38| 49| 70| 3
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49- 70 (34.21/19.10) EKSLVDEIES..LESSKTVDEALD
88- 111 (30.72/16.50) EESVQEKFNSkkLELTKSINNALN
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|