<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28579

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGSITNIRAIDGFSHIYWRIYTDDPGESPSNGYAILKHLSRLKDLELQLRDRNCLVSSYPRRLCLWVFSATPGFESLSPLSPNDGRDDSGRLAIGSATLKVSSSGNVSAVDLVKNLSTETQNASGSAGSQRPNAMTPFATIYASFISAVSGAVSLQLVRQRNAIPLGSRTLFTVVEKDGCDNSHVSKNDLALAPSLTTLQIQLTSAGKLTVALQTVSQAGLTRLLTPEEVPASIHDTPPGTDLWLSPSGSIARLVAANPPQLNAGSPYPSNVGGSGNEKSSPATRKQWKVNVLWWLSNFGLPVDGIDDEAWVEVEVWEPFYSRLAGEVWRPSEEGASMLPLKRILWPAIYCFRRTKSASSEFYGEMEGVSSIAGDPLDFAEKWRVTEKLSFAEASPKPPSVHQEAPTKDQDASSPDLLNLPEGIESLSRASQYPDLQTASLVYPTPPDGAAATGLNPLVTSDTFTDDIEQNSNFMQQDRLNHHRQLSKERTGTDVISFGPSAGLVVGSGLYDTNDDDDLFGDMNEKDFGTKGITDADFSFFDDPDFDRGGVGEQAEAIQELSGFMDTDEPEIQATVDGQASPEQTPAMNIASAQLSPVVATADMQPEKTPQEAKAPVFTPQEDKPRTISPPLSPVEVKKILFPESQLESQRPAKKGQGPGYYNAVAFKQNMSLWDKKYGADGKFGFNLRGIERNKGPDTVTNDIPTVGLPRHSGKMKSSTSKDPDNYGSPYSEEMQESSSDSDMSSSVSADSDESASESGLSPATFSTRKRKRTRSNSGTSLALSQDKSTVRTGQETAAQRPEDSVFLGNFLSTFSDWSMAGYFSLAQNQVSPVLIRKDIQVQVAQLLVDQVTQSSLDHKIDGTLGLLDYADEVCSPETLQGDAAFVRGMERLDLNSFVSLQDSNALSPSSSNGANPRQSSQRRETGKGTIVKIPPPHLRVRRGKDFLETLPPAISFWETFGLEPAHGRKDILAYCIHPHFAARAADTFLERLGLVYSGCNLGEHRRGESSNVFDRGLGSWNISSSADSRYSEVIQSLKTICGVLGSAFLSTPPSKDSNIVVYIVNPFTHATSLVDICAAFWSLFQQYIAEADKQQTRQLNELVLQIIPMDFVTSAESLVVPPQAEYLNLALEVYSRCPPKSSEVGPVNCAPPVLLAEPIPRSIGFKLSSEGSSPLQEGKHLHIACSRSLDQRWLSVAWSDNFGALQRNMSYCLRYRNSVAARPLPEVRGEIWKATRDIMDTIQTRWKVIIVSTDPVDQEEVDTWTNFADQYGKARSMTLDLVILGATTPPDLHLEPPYLPIPLSMFNQQPSSTPVATPNLGGGVSSPDQFGTAPTPPGGWGAPANASTPTDTFPEVESESLLTDIYDETWGVVLSHRLNSSLHQTEYRPALASGYLLRRKGSTDGDGLYTMSVNILFARRSPSSYDTLLREILGMYRDLATLARARGTRTVQQGTLPWHVATAIKAQTLLSYAL
Length1479
PositionKinase
OrganismAspergillus kawachii (strain NBRC 4308) (White koji mold) (Aspergillus awamori var. kawachi)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.381
Instability index50.75
Isoelectric point5.06
Molecular weight161044.06
Publications
PubMed=22045919

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28579
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     430.45|     189|     890|     251|     534|       1
---------------------------------------------------------------------------
  251-  534 (262.16/301.09)	P..SGSIARLVAANPPqlNAGSPYPSNV..GGSGNEKSSPatrkqwkvnvlwwlsnfglpvdgiddeawvevevwepfysrlageVWRPSEEGASMLPLKrilwPAIYCFRRTKSASSEfygemEGvSSIAgdpldfaekwrvteklsfaeaspkppsvhqeaptkDQDASSPDLLNLPEGIESLS..RASQYPDLQTA..SLVYP..TPPDGAAATGLNPLV.TSDTFTDDIEQNSN...FMQQDrlNHHRQLSKERTGTDV..ISFgPSAGL.............................VVGS.GLYDTN...DDDDLFGDMNEKDFGT
  547-  710 (114.29/37.32)	......................................................................................................................................................................DPDFDRGGVGEQAEAIQELSgfMDTDEPEIQATvdGQASPeqTPAMNIASAQLSPVVaTADMQPEKTPQEAKapvFTPQE..DKPRTISPPLSPVEVkkILF.PESQLesqrpakkgqgpgyynavafkqnmslwdkKYGAdGKFGFNlrgIERNKGPDTVTNDIPT
  714-  787 (54.00/14.21)	PrhSGKMKSSTSKDPD..NYGSPYSEEMqeSSSDSDMSSS.............................................VSADSDESASESGLS....PATFSTRKRKRTRSN.....SG.TSLA..........................................................................................................................................................................................................
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      51.20|      13|      27|       2|      14|       3
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    2-   14 (25.03/13.90)	DFPGGSITNIRAI
   27-   39 (26.16/14.89)	DDPGESPSNGYAI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.87|      20|      27|      73|      99|       4
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   69-   88 (37.36/29.60)	LWVFSATPGFESLSPLSPND
   96-  115 (31.51/10.26)	LAIGSATLKVSSSGNVSAVD
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     493.72|     162|     411|     854|    1040|       5
---------------------------------------------------------------------------
  854- 1040 (246.67/137.07)	DQVTQSSLDhkidgtlGLLDYADE...............VCSPETLQGDAAFVrgmeRLDLNSFvslqdsnALSPSSSNGANPRQSSQRRETGKGTIVKIPP...........PHLRVRRGKDflETLPPAIsFWETFGLEPAHgRkdiLAYCIH..PHFAARAADTFLERL......GLVYSGCNLGEHRRGESS..NVFDRGLGSW.NISSSADSRYSEVIQ
 1259- 1457 (247.04/100.78)	DPVDQEEVD.......TWTNFADQygkarsmtldlvilgATTPPDLHLEPPYL....PIPLSMF.......NQQPSSTPVATPNLGGGVSSPDQFGTAPTPPggwgapanastPTDTFPEVES..ESLLTDI.YDETWGVVLSH.R...LNSSLHqtEYRPALASGYLLRRKgstdgdGLYTMSVNILFARRSPSSydTLLREILGMYrDLATLARARGTRTVQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.99|      31|     667|     134|     169|       6
---------------------------------------------------------------------------
  134-  164 (52.41/43.42)	QRPNAMTP.FATIYASFISAVSGAVSLQLVRQ
  191-  222 (44.58/23.99)	KNDLALAPsLTTLQIQLTSAGKLTVALQTVSQ
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28579 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) DLQTASLVYPTPPDGAAATGLNPLVTSDTFTDDIEQNSNFMQQDRLNHHRQLSKERTGTD
2) GFNLRGIERNKGPDTVTNDIPTVGLPRHSGKMKSSTSKDPDNYGSPYSEEMQESSSDSDMSSSVSADSDESASESGLSPATFSTRKRKRTRSNSGTSLALSQDKSTVRTGQETAAQ
3) QPSSTPVATPNLGGGVSSPDQFGTAPTPPGGWGAPANASTPTDTFPEVES
4) SFFDDPDFDRGGVGEQAEAIQELSGFMDTDEPEIQATVDGQASPEQTPAMNIASAQLSPVVATADMQPEKTPQEAKAPVFTPQEDKPRTISPPLSPVEVKKILFPESQLESQRPAKKGQGPGYY
439
689
1314
543
498
804
1363
666










Molecular Recognition Features






MoRF SequenceStartStop




1) HIYWRIYT
2) VKKILF
19
641
26
646