<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28569

Description Uncharacterized protein
SequenceMFTLRTPNRRRKKQLNAAFLPQDELTALNVKQGFNNQPAVSGDEHGSAKNVSFNPAKISSNFSSIIAEKLRCNTLPDTGRRKPQVNQKDNFWLVTARSQSAINTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAISETKVKKRHVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGGGGCGSTIGPLPHDVEVAIRQWDYTEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQNNFGSGIYGFGLRMGFQRGSHVNELDLAVSIWQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSIASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPPKEKIEGTLGVLYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKNKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSGGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIVNNWRDDQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAMLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLAKKLQKELGERQSDSLEKVRQLLPLPKQTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEACSIVCPLRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPAAKTEDYGMGPGRSGPYGVTVPPDLLHHPNPGSITHLNYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMISTMTPMSAQGVQAGVRSTAILPEQQQQQQQQQQQQQQQQYHIRQQQQQQILRQQQQQQQQQQQQQQQQQQQQQQYHIRQPTATTATPAATAATGGSSPTPAPVPAPGSYWTRAPGSGTTAQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2189
PositionKinase
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.458
Instability index55.99
Isoelectric point6.95
Molecular weight243345.33
Publications
PubMed=22002653

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28569
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     264.85|      33|      34|    2039|    2071|       1
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 1898- 1940 (35.59/14.55)	QQPAVPQGQRLRQ...............................qlQ..A.....KIQSQGML.....GQSSVHQMtpsssyglQT
 1941- 1975 (41.04/18.05)	SQGYTPYVSHVGL.................................QqhT.....GPAGTMVP.....PSYSSQPY........QS
 1992- 2021 (30.62/11.37)	QQRPSG...YVHQ.................................Q..AptyghGLTST..........QRFSHQ........TL
 2022- 2058 (48.12/22.59)	QQTPMISTMTPMS.............................aqgvQ..A.....GVRSTAIL.....PEQQQQQQ........QQ
 2059- 2093 (43.96/19.92)	QQQQQQQQYHIRQ...............................qqQ............QQILrqqqqQQQQQQQQ........QQ
 2094- 2156 (35.36/14.41)	QQQQQQQQYHIRQptattatpaataatggssptpapvpapgsywtrA..P.....GSGTTA........QFQRQGL........QQ
 2157- 2176 (30.17/11.08)	TQQQQQ.....................................................TAAL.....VRQLQQQL........SN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     413.12|     132|     231|     388|     616|       2
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  391-  534 (207.81/102.50)	ILLCCP...SALVWH..YSLT.DSR..IKTGSPldhLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWS..FDKCQEatAGFTIGRVLHTLEVLDSHSFERSDFSNSL.DSLCNRIFG.LGpskdgheISSDDDAVVSLLCEWAV
  619-  762 (205.32/164.05)	VLLFCElirHDVFSHnmYTCTlISRgdLAFGAP...GPRPPSPFDDPADDPEHKEAEGSSSSKLEDPGLSESMDIDPSSSvlFEDMEK..PDFSLFSPTMPCEGKGSPSPEKPDVEKEVkPPPKEKIEGtLG.......VLYDQPRHVQYATHFPI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     875|     889|       3
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  875-  889 (26.85/14.71)	LEQITSFALG.MSYHL
  891-  906 (23.14/11.72)	LVQHVQFIFDlMEYSL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|    1049|    1061|       4
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 1049- 1061 (25.11/17.80)	ENPAA.HTFTYTGL
 1067- 1080 (21.03/13.49)	ENPANrYSFVCNAL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     641.25|     180|     200|    1249|    1443|       5
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 1095- 1211 (138.42/75.92)	...............................................DIAILCAELTGYCKSL.....SAEWLG..VLKALCCSSNN.............................................GTCGFNDLLCNVDVSDLSfHDSLATFVAILIA.......RQCL....LLEDLIRcAAIPSLLNAAcsEQDSEPGArlTCRILLHLFKT.PQLNPCQ
 1249- 1443 (283.69/194.95)	VFVLGD..AELKGS..GFTVTGGTEELpeEEGGG.GSGGRRQGGR..NISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDL.....QDPVLSSaqaqrlmqliCYPHRLLD.......NEDGenPQRQRIKRILQNLDQWTMR.QSSLELQLMIKQT....PNNEMNS....LLENIAK.ATIEVFQQSA..ETGSSSGS..TASNMPSSSKTkPVLSSLE
 1447- 1641 (219.13/125.47)	VWLVAPliAKLPTSvqGHVLKAAGEEL..EKGQHlGSSSRKERDRqkQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYSQVHQIvnnwrDDQYLDD..........CKPKQLMHealklrlNLVG..GMFDTVQRSTQQTTEWAM.....LLLEIIISGTvdmqSNNELFTtvldMLSVLIN.GTLAADMSSI..SQGSMEEN..KRAYMNLAKK.........
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.99|      25|     235|      58|      83|       7
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   58-   83 (39.96/23.98)	ISSNFSSIIAEKlRCNTLPDTGRRKP
  301-  325 (44.02/22.71)	VSSHSSHVISAQ.STSSLPTTPAPQP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     188.35|      63|     230|     535|     599|       8
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  535-  599 (95.07/71.74)	SCKRSGRHRAMVVAKLLEKR.QAEIEAERCGES..EAADEKGSIASGSLsAPSAPIfQDVLLQFL...DTQ
  767-  835 (93.28/60.89)	SCSHECNQRLVVLFGVGKQRdDARHAIKKITKDilKVLNRKGTAETDQL.APIVPL.NPGDLTFLggeDGQ
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|      90.72|      17|      29|    1757|    1773|       9
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 1757- 1773 (30.71/16.87)	EKKAPE....PP...KTDKPGAAP
 1780- 1796 (20.75/ 8.30)	KKKSTK....GK...KRSQPAAKT
 1804- 1827 (19.53/ 7.25)	GRSGPYgvtvPPdllHHPNPGSIT
 1863- 1876 (19.74/ 7.43)	.QKLPT....RP...TY..PGVLP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.93|      31|      44|     947|     988|      10
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  947-  978 (52.90/42.54)	CIVAVL.RHYHACLILnQDQMAQVFEGLCGVVK
  992- 1023 (53.04/21.42)	CILAYLyDLYTSCSHL.KNKFGELFSDFCSKVK
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.20|      14|    1646|     195|     212|      12
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  195-  212 (24.13/21.33)	RPGPAGgggcGSTIGP.....LP
 1843- 1861 (24.08/ 9.74)	QPLPAG....GPRVDPyrpvrLP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28569 with Med12 domain of Kingdom Metazoa
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