<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28568

Description Mediator complex subunit 14
SequenceMVDFSGQIVAFTTPGGGGGRESSKGKGGATADVPADDSDSALTLVSGGARLPFPLSRARTDTHRSHSPPPLRLPRKSDVERKIEIVQFASRTRQLFVRLLALVKWANNAGKVEKCAMISSFLDQQAILFVDTADRLASLARDALVHARLPSFAIPYAIDVLTTGSYPRLPTCIRDKIIPPDPITKIEKQATLHQLNQILRHRLVTTDLPPQLANLTVANGRVKFRVEGEFEATLTVMGDDPDVPWRLLKLEILVEDKETGVRSVTFPNSNVNPRTVGRPCTGGKVSCWKVPLPLSLEVLGRKTGTASVHKVTIKIDENDVSKPLQIFHDPPLPASDSKLVERAMKIDHLSIEKLLIDSVHARAHQKLQELKAILRGFNANENYQATLDDMEKSVNDDMKRIIPWIQQLKFWLGQQRCKQSIKHLPTISSETLQLSNYSTHPIGNLSKNKLFIKLTRLPQYYIVVEMLEVPNKPTQLSYKYYFMSVNAADREDSPAMALLLQQFKENIQDLVFRTKTGKQTRTNAKRKLSDDPCPVESKKTKRSGEMCAFNKVLAHFVAMCDTNMPFVGLRLELSNLEIPHQGVQVEGDGFSHAIRLLKIPPCKGISEETQKALDRCLLDCTFRLQGRNNRTWVAELVFANCPLNGTSTREQGPSRHVYLTYENLLSEPVGGRKVVEMFLNDWNSIARLYECVLEFARSLPDIPAHLNIFSEVRVYNYRKLILCYGTTKGSSVLFDTQAPLNAINKLPTVPMLGLTQRTNTAYQCFSILPQSSTHIRLAFRNMYCIDIYCRSRGVVAIRDGAYSLFDNSKLVEGFYPAPGLKTFLNMFVDSNQDARRRSVNEDDNPPSPIGGDMMDSLISQLQPPPQQQPFPKQPGTSGAYPLTSPPTSYHSTVNQSPSMMHTQSPVCPTAARVILLGQKFVHDFRSKLCIGFPLIQGNLHAASSPSGALRAPSPASFVPTPPPSSHGISIGPGASFASPHGTLDPSSPYTMVSPSGRAGNWPGSPQVSGPSPAARMPGMSPANPSLHSPVPDASHSPRAGTSSQTMPTNMPPPRKLPQRSWAASIPTILTHSALNILLLPSPTPGLVPGLAGSYLCSPLERFLGSVIMRRHLQRIIQQETLQLINSNEPGVIMFKTDALKCRVALSPKTNQTLQLKVTPENAGQWKPDELQVLEKFFETRVAGPPFKANTLIAFTKLLGAPTHILRDCVHIMKLELFPDQATQLKWNVQFCLTIPPSAPPIAPPGTPAVVLKSKMLFFLQLTQKTSVPPQEPVSIIVPIIYDMASGTTQQADIPRQQNSSVAAPMMVSNILKRFAEMNPPRQGECTIFAAVRDLMANLTLPPGSAPAHCRPPRLRTAVRHAPQSPGYKREDMVLSELAARLNCAEYKNWVKAGHCLLLLRSCLQGFVGREPQCQVCAEWKQEILRHHVNRNGDVHWGNCRPGRWPVDAWEVAKASVSGDYYFSSANPHSRSSALAHASRN
Length1480
PositionTail
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.07
Grand average of hydropathy-0.267
Instability index52.54
Isoelectric point9.40
Molecular weight163476.57
Publications
PubMed=22002653

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28568
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     171.84|      34|      37|     944|     977|       1
---------------------------------------------------------------------------
  846-  877 (45.75/17.78)	PSPIGGDMMDSLISQL.Q..PP......PQQQPFPKQPGTS.
  943-  976 (64.66/28.38)	SSPSGALRAPSPASFVPT..PP......PSSHGISIGPGASF
  977- 1010 (34.38/11.40)	ASPHGTLDPSSPYTMV.S..PSgragnwPGSPQVS.GP....
 1035- 1061 (27.05/ 7.28)	....HSPRAGTSSQTMPTnmPP......PRKL.....PQRSW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     186.56|      62|     254|      19|      85|       2
---------------------------------------------------------------------------
   19-   85 (89.89/61.52)	GRESSKGKgGATADVPADDSDSALTLVSGGARL.PFPLSRARTDTHRS....HSPPpLrlPrKSD...VERKIEI
  277-  346 (96.67/49.05)	GRPCTGGK.VSCWKVPLPLSLEVLGRKTGTASVhKVTIKIDENDVSKPlqifHDPP.L..P.ASDsklVERAMKI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.97|      24|      24|    1255|    1278|       3
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 1255- 1278 (40.59/21.53)	MLFFL..QLTQKTSVPPQEPVSIIVP
 1279- 1304 (33.39/16.23)	IIYDMasGTTQQADIPRQQNSSVAAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.49|      14|      25|     168|     181|       6
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  168-  181 (26.30/14.59)	RLPTCIRDKII....PPD
  194-  211 (19.19/ 8.49)	QLNQILRHRLVttdlPPQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.60|      14|      37|    1139|    1153|       8
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 1139- 1153 (21.47/16.83)	LKCRVALSP.KTNqTL
 1177- 1191 (22.14/11.86)	FETRVAGPPfKAN.TL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.32|      23|     533|     796|     822|       9
---------------------------------------------------------------------------
  796-  822 (37.72/29.95)	AIRDgaysLFDNSKLVEGFYPA....PGLKT
 1330- 1356 (37.59/19.87)	AVRD....LMANLTLPPGSAPAhcrpPRLRT
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.74|      13|     253|     642|     654|      10
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  642-  654 (24.74/12.96)	PLNGTSTREQGPS
  886-  898 (24.00/12.34)	PTSYHSTVNQSPS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      36.68|      12|      36|      95|     106|      11
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   95-  106 (21.76/16.21)	LFV....RLLALVKWA
  128-  143 (14.92/ 8.42)	LFVdtadRLASLARDA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     112.07|      37|     979|     456|     497|      12
---------------------------------------------------------------------------
  423-  454 (32.37/13.82)	HLPT..ISSETLQLSNYSTHpignLSKNKLFIKL...........
  456-  496 (58.06/49.54)	RLPQyyIVVEMLEVPNKPTQ....LSYKYYFMSVNAADRedSPAM
 1457- 1474 (21.64/ 8.42)	.........................SGDYYFSSANPHSR..SSAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.74|      15|      44|     779|     794|      13
---------------------------------------------------------------------------
  779-  794 (26.01/19.42)	FRNMYcIDIY..CRSRGV
  823-  839 (22.73/11.11)	FLNMF.VDSNqdARRRSV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.99|      33|      44|     693|     731|      15
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  693-  731 (44.27/45.86)	LEFARSLPDIPaHLNIFSEVRVyNYRklilCYGTTKGSS
  740-  772 (57.73/37.06)	LNAINKLPTVP.MLGLTQRTNT.AYQ....CFSILPQSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      75.47|      23|      36|     351|     374|      16
---------------------------------------------------------------------------
  351-  374 (32.42/25.81)	IEKLLIDSVHaRAHQKLQELKAIL
  390-  412 (43.05/29.91)	MEKSVNDDMK.RIIPWIQQLKFWL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28568 with Med14 domain of Kingdom Metazoa
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