<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28566

Description Mediator complex subunit 26
SequenceMSTGCQIRNMVAVLEVISSLEKYPITKEALEETRLGKLINDVRKKTKNEELAKRAKKLLRSWQKLIEPAHQHEAALRGLAGAAGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFPGSLDGSGHAGPEGGRLERGENDKHSGKIPINAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVRWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHHFMSEYLKQEESTRQGARQLHVLVPQSPPTDLPGLTRDITQDDLDRIQASQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNILPYVCLD
Length582
PositionUnknown
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.04
Grand average of hydropathy-0.861
Instability index61.84
Isoelectric point9.38
Molecular weight63394.44
Publications
PubMed=22002653

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28566
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     458.77|      98|      99|     203|     300|       1
---------------------------------------------------------------------------
   91-  189 (85.45/36.14)	.............HNCRP..EVG.A......AGP....PR.SIhdLksrndlqrlpgQRLDRLGSrkrrgdqrdlgHPGPP.PKvskashDPlvPNSSPLPTN........................GISGSPESFPGSLDGSGHA....GPEGG
  203-  300 (182.85/87.03)	IPINAVR.....PHTSSP..GLGKP......PGP.CLQPKASV..L...........QQLDRVDE...........TPGPPHPK......GP..PRCSFSPRNSRHE.......GSFARQQSLYAPKGSVPSPSPRPQALDATQVP....SPLPL
  305-  402 (87.68/37.31)	TP..PVRrlellPSAESPvrWLEQPeshqrlAGPgC...KAGL.................................SPAEPLL...........SRAGFSPDSSKADsdaassgGSDSKKKKRYRPRDY.......TVNLDG.QVAeagvKPVRL
  411-  487 (102.78/45.19)	PMTRQIK.....PLTQKE..PV.RA......DSP.VHMEQQS...R...........TELDKQEA...........KASLQSPF......EQ..TNWKELSRNEIIQ.......SYLSRQSSLLSSSGA.QTP......................
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28566 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) HQHEAALRGLAGAAGSANGGAHNCRPEVGAAGPPRSIHDLKSRNDLQRLPGQRLDRLGSRKRRGDQRDLGHPGPPPKVSKASHDPLVPNSSPLPTNGISGSPESFPGSLDGSGHAGPEGGRLERGENDKHSGKIPINAVRPHTSSPGLGKPPGPCLQPKASVLQQLDRVDETPGPPHPKGPPRCSFSPRNSRHEGSFARQQSLYAPKGSVPSPSPRPQALDATQVPSPLPLAQPSTPPVRRLELLPSAESPVRWLEQPESHQRLAGPGCKAGLSPAEPLLSRAGFSPDSSKADSDAASSGGSDSKKKKRYRPRDYTVNLDGQVAEAGV
2) PVRLKERKLTFDPMTRQIKPLTQKEPVRADSPVHMEQQSRTELDKQEAKASLQSPFEQ
3) RQGARQLHVLVPQSPPTDLPGLTRDITQDDLDR
70
399
504
397
456
536










Molecular Recognition Features






MoRF SequenceStartStop




1) KKKKRYRPRDYTVNL
2) VRRLELLP
374
308
388
315