<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28557

Description Mediator of RNA polymerase II transcription subunit 13 (Fragment)
SequenceFLQADLTGIKWKKYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGEDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHITLAQQSNSPFQVILCPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCCLKEMSEEKQEDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPTPSPVGSTHCSSSCLGVHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFNSDSTSHHGGKIPRKLANHVVDRVWQECNMNRAQNKRKYSASSGGLCEEVTAAKVASWDFVEATQRTNCSCLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFPPQYQEAVEPTVYVGTAVNLEEDEANIAWKYYKVPKKKDVEFLPPQLPSDKFKDDPVGPFGQESVTSVTELMVQCKKPLKISDELVQQYQIKNQYLSAIASDAEQEPKIDPYAFVEGDEEFLFPDKKDRQNSEREAGKKHKVEDGTSSVTVLSHEEDAMSLFSPSIKQDAPRPASHARPPSTSLIYDSDLAVSFTDLDNLFNSDEDELTPGSKKSANGSDDKTSCKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSMDTTPGGTVLEGNSSSIGAQFKIEVDEGFCSPKPSEIKDFSYVYKPENCQILVGCSMFAPLKTLPSQYLPPIKLPEECIYRQSWTVGKLELLSSGSAMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAIMNRKFGNSSGLFLEDELDIIGRNTDCGKEAEKRFEALRGTSAEHVNGGLKESEKLSDDLILLLQDQCTNLFSPFGAADQDPFPKSGVISNWVRVEERDCCNDCYLALEHGRQFMDNMSGGKVDEALVKSSCLHPWSKRNDVSMQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDYLVLSPFALPYWERLMLEPYGSQRDIAYVVLCPENEALLNGAKSFFRDLTAIYESCRLGQHRPVSRLLTDGIMRVGSTASNKLSEKLVAEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASLPLDSSLLSQPNLVAPTSQSLITPPQMTNTGNANTPSATLASAASSTMTMTSGVAISTSVATANSTLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENTDESANSSSVWTLGLLRCFLEMVQTLPPHIKSTVSVQIIPCQYLLQPVKHEDREIYPQHLKSLAFSAFTQCRRPLPTSTNVKTLTGFGPGLAMETALRSPDRPECIRLYAPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKSSARKFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTSQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTGSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHEEVPNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAIQDRRSCLPIHFVVLNQLYNFIMNML
Length2155
PositionMiddle
OrganismMacaca fascicularis (Crab-eating macaque) (Cynomolgus monkey)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Primates> Haplorrhini> Catarrhini> Cercopithecidae> Cercopithecinae> Macaca.
Aromaticity0.08
Grand average of hydropathy-0.401
Instability index53.08
Isoelectric point5.40
Molecular weight237424.21
Publications
PubMed=22002653

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28557
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     131.75|      38|     421|     533|     570|       1
---------------------------------------------------------------------------
  512-  543 (42.10/13.98)	.PQPPPLSP.HPC.DVVDE.................................gvtktPSTPQSQHFYQ
  544-  609 (53.48/19.70)	MPTPDPLVPSKPMEDRIDSLS.QSFP.PQyqeaveptvyvgtavnleedeaniawkyYKVPKKKDVEF
  967- 1000 (36.17/11.00)	MP.PSSAPPSNSGAGILPSPStPRFPtPR...........................tPRTPR......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.10|      25|      28|    1079|    1106|       3
---------------------------------------------------------------------------
 1081- 1105 (47.11/28.05)	MNIK.GADVGVYIPDPTQEAQYRCTC
 1111- 1136 (41.00/20.29)	MNRKfGNSSGLFLEDELDIIGRNTDC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      79.13|      22|      26|    1309|    1330|       4
---------------------------------------------------------------------------
 1309- 1330 (42.16/28.96)	P..EPLPIPTFLLGYDYDYLVLSP
 1334- 1357 (36.97/24.27)	PywERLMLEPYGSQRDIAYVVLCP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     436.62|     178|     425|     226|     457|       5
---------------------------------------------------------------------------
  231-  319 (114.36/50.43)	...............................................................................................................................................................................................................................................................................................................................................................................................SEEKQEDMDWED.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DSLAAVEVLV...AGVRMIYPACFVLVPQSDIPTPS....PVGSTHCSSSCLGVHQVPASTRDPAMSS..VTLTPPTSPEEVQTVD
  320-  457 (82.30/109.95)	PQSAQKWVKFSSVsDGFNSDSTS..HHGGKIPRKLANHVVDrvWQECNMNraqNKR..KYSASSGGLCEEvtaakvaswdfveatqrtncsclrhknlksrnagqqGQAPSLGQQQQIlpkhktnEKQEKSEKPQKRPLTPF........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  699-  787 (72.15/20.02)	..............................................................................................................................................hhrvsvsddvgmdtdsasqrlvisapdsqvrfsnirtndvaktpqmhgtemanspqppplsphpcdvvdegvtktpstpqsqhfyqmptpdplvpskpmedridslsqsfppqyqeaveptvyvgtavnleedeaniawkyykvpkkkdveflppqlpsdkfkddpvgpfgqesvtsvtelmvqckkplkisdelvqqyqiknqylsaiasdaeqepkidpyafvegdeeflfpdkkdrqnSEREAGKKHKVE.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................DGTSSVTVLSheeDAMSLFSPS....IKQ.DAPRPAsharPPSTSLIYDSDLA...VSFTDLDNLFNSdeDELT.PGSKKSANGSD
  788-  880 (110.38/52.36)	DKTSCKESKTGNL.DPLSCISTAdlHKMYPTPPSLEQHIMG..FSPMNMN...NKEygSMDTTPGGTVLE....................................GNSSSIGAQFKI.......EVDEGFCSPKPSEIKDF........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1974- 2036 (57.44/11.79)	...........................................................................................................................................................................................................................................................................................................................................................................................................syvykpencqilvgcsmfaplktlpsqylppiklpeeciyrqswtvgklellssgsampfikegdgsnmdqeygpaytpqthtsfgmppssappsnsgagilpspstprfptprtprtprtprgaggpasaqgsvkyensdlyspastpstcrplnsvepatvpsipeahslyvnlilsesvmnlfkdcnfdsccicvcnmnikgadvgvyipdptqeaqyrctcgfsaimnrkfgnssglfledeldiigrntdcgkeaekrfealrgtsaehvngglkeseklsddlilllqdqctnlfspfgaadqdpfpksgvisnwvrveerdccndcylalehgrqfmdnmsggkvdealvkssclhpwskrndvsmqcsqdilrmllslqpvlqdaiqkkrtvrpwgvqgpltwqqfhkmagrgsygtdespeplpiptfllgydydylvlspfalpywerlmlepygsqrdiayvvlcpeneallngaksffrdltaiyescrlgqhrpvsrlltdgimrvgstasnklseklvaewfsqaadgnneafsklklyaqvcrydlgpylaslpldssllsqpnlvaptsqslitppqmtntgnantpsatlasaasstmtmtsgvaistsvatanstlttastssssssnlnsgvssnklpsfppfgsmnsnaagsmstqantvqsgqlggqqtstlqtagisgessslptqphpdvsestmdrdkvgiptdgdshaityppaivvyiidpftyentdesansssvwtlgllrcflemvqtlpphikstvsvqiipcqyllqpvkhedreiypqhlkslafsaftqcrrplptstnvktltgfgpglametalrspdrpecirlyappfilapvkdkqtelgetfgeagqkynvlfvgyclshdqrwilasctdlygelletciinidvpnrarrkkssarkfglqklwewclglvqmsslpwrvvigrlgrighgelkdwscllsrrnlqslskrlkdmcrmcgisaadspsilsaclvamepqgsfvimpdsvstgsvfgrsttlnmqtsqlntpqdtscthilvfptsasvqvasatyttenldlafnpnndgaDGMGIFDLLD...TGDDL.DPDIINILPAS..PTGS....PVHSP.......GSHYPHGGDVGKGQST..DRLLSTEPHEEV....
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.78|      13|      15|    1008|    1020|       6
---------------------------------------------------------------------------
 1008- 1020 (23.30/11.04)	PASAQGSVKYENS
 1025- 1037 (25.48/12.80)	PASTPSTCRPLNS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     113.38|      35|     425|    1649|    1708|       7
---------------------------------------------------------------------------
  610-  646 (58.84/25.22)	LPPQLPS...............DKFKDDPVGPfgQESVTSVTELMVQCKKPL
 1658- 1707 (54.54/49.69)	LPPHIKStvsvqiipcqyllqpVKHEDREIYP..QHLKSLAFSAFTQCRRPL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.61|      29|     425|    1492|    1522|       8
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 1492- 1520 (46.24/22.71)	SSTMTMTSGVAIS..TSVATANSTLTTASTS
 1522- 1552 (46.37/29.30)	SSSSNLNSGVSSNklPSFPPFGSMNSNAAGS
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.99|      15|      26|    1577|    1593|       9
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 1577- 1593 (19.21/19.27)	GI..SGESSSLpTQPhPDV
 1604- 1620 (24.78/12.19)	GIptDGDSHAI.TYP.PAI
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     146.41|      45|     533|    1203|    1291|      10
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 1241- 1291 (76.58/97.88)	CL.HP..WskrndVSMQCSqDILRMLLSLQPVLQD....AIQKKRTVRPWGVQGPLTW
 1776- 1827 (69.83/23.89)	CLsHDqrW.....ILASCT.DLYGELLETCIINIDvpnrARRKKSSARKFGLQKLWEW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      93.41|      28|     500|     913|     965|      11
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  473-  504 (43.71/10.76)	SASQRLVISAPDSqvrfSNI.RTNDVAKTPQMH
  934-  962 (49.70/ 6.92)	SGSAMPFIKEGDG....SNMdQEYGPAYTPQTH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.57|      31|     738|     647|     682|      12
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  647-  682 (46.79/47.24)	KISDELVQQYqiknqYLSAIASDAEQEPKIDPYAFV
 1406- 1436 (51.78/38.31)	KLSEKLVAEW.....FSQAADGNNEAFSKLKLYAQV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28557 with Med13 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AMPFIKEGDGSNMDQEYGPAYTPQTHTSFGMPPSSAPPSNSGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENS
2) CLRHKNLKSRNAGQQGQAPSLGQQQQILPKHKTNEKQEKSEKPQKRPLTPFHHRVSVSDDVGMDTDSASQRLVISAPDSQVRFSNIRTNDVAKTPQMHGTEMANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPSKPMEDRIDSLSQSFP
3) GSPVHSPGSHYPHGGDVGKGQSTDRLLSTEPHE
4) NLFNSDEDELTPGSKKSANGSDDKTSCKES
5) STLTTASTSSSSSSNLNSGVSSNKLPSFPPFGSMNSNAAGSMSTQANTVQSGQLGGQQTSTLQTAGISGESSSLPTQPHPDVSESTMDRDKVGIPTDGD
6) VAPTSQSLITPPQMTNTGNANTPSATLASAA
937
407
2002
766
1512
1461
1020
568
2034
795
1610
1491










Molecular Recognition Features






MoRF SequenceStartStop




NANANA