<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28530

Description "Putative mediator complex, subunit Med12"
SequenceMQRYHAGSCTSAVNNSTIGGPSSRDTGRSDSSFPAHFPVNSRSSIHKSNPDLITMGSRSKQNIKGQPKRFPIMRRQPQLNINPYKLKCDKEPLNSRLGAPDFLPQTPNCPEETLTKEYLQSGYRDTVEGLEEAREISLTQVPHFNKPIVHNCREAIKKRLRAINESRAQKRKAGQVYGVPLSGLQLAKPGIFPELRPCGEDFRKKWIEGLSQPHKRLCTLADHVPHGYKRSSLLEVLIRNNVPLLRATWFVKVTYLNQVRPGSVGISSGTADKIQPSRTEIWTKDVIHYLQTLLDEFFSKNNSHSTLQNRERSPQMPYAGTLLHKSDPLSSFSAGEEPSSHFRWWYIVRLLQWHHAEGLILPSLVIDWVLNQLQEKDLLEVWELLLPIIYGFLEIIVLSQSYVRALAGLTLRVIRDPAPGGSDLVDNSRRAYTTYALIEMLQYLILAVPDTFVALDCFPLPSSVVSHTMNDGSFVLKSSEAAGKIKNSSDYFGRIVLCIQKRAEDLAKAASPGNPSHCLAKVAKALDNSLVLGDLREAYKFLFEDFCDGTVSESWIVKVSPCLRLSLKWFGTVKTSLIHSVFFLCEWATCDFRDFCTTPPCDIKFTGRKDLSQVHIAVRLLKMKLRDVKSSLRRAKRSIHRASYAAKHESQRHNQNYITTGSSVISESPGPLHDIIVCWIDQHVVHKGEGLKRLHLFIVELIRAGIFYPLAYVRQLIVSGIMNMDVNVVDVERRKRHSHILKQLPGHFMRDALTESGIAEGPQLIEALQTYLTERRLILRNSPSDPRDDANANNAKLPTLKRKRNPASSKDGTSTVSTDQWKTVQSTASSKSAKDGASMEELKETISVLLQLPNSLSNLNSTGCDESESSVRKPTWPHYGKTEPVEGTPGCEECRRAKRQKLSEERSSSVPADDDTWWVKKGLKSTEPLKVDQPQKTTKQVTKSRQKNVRKMSLAQLAASRIEGSQGASTSHMCENKVSCPHHRTPVDGDALRSVDSMRTCDSRDIVFIGKALKKLRFVEKRAVAAWLLTVVKQVIEETEKNIGKVGQFGRAYSMVDDRNSIRWKLGEDELSAILYLIDISDDLVSAVKFLLWLMPKVLSSPNSTIHSGRNVLMLPRNAENQVCDVGEAFLLSSLRRYENILVAADLIPEALSSTMHRAATLIASNGRVSNSGATAFTRYLLKKYSNVASVIEWEKTFKSTCDARLSAELESVRSVDGELGLPFGVPAGVEDPDDFFRQKISGSRLPSRVGAGMRDIVQRNVEEAFQYLFGKDRKLYAAGIPKGHALEKWDNGYQIAQQIVMGLIDSIKQTGGAAQEGDPSLVLSAVSAIVGSVGPTLAKMPDFSSSNNQSNIMSLNYARCILRMHITCLRLLKEALGERQSRVFDIALATEASNVFAGVFAPSKASRAQFQMSSAEVHDTSATNSNELGNNSIKTVVTKATKIAAAVSALVVGAVIYGVTSLERMVTILRLKEGLDVIQCIRTTRSNSNGNVRSVGAFKADSSIEVHVHWFRLLIGNCRSLCEGLAVDLLGEPSISALSRMQRMLPLSLIFPPAYSIFAFVRWRPFILNANVAVRDDMNQLYQSLTMAIADAIKHSPFRDVCFRDCQGLYDLMVADGSDAEFAALLELNGSDMHLKSMAFVPLRSRLFLDAMIDCKMPPSIFTKDDVNRVSGPSESKTKLANGDSKLPDKLVHVLDTLQPAKFHWQWVALRLILNEQTLIEKLDTHDASLSDAIQLASPGPDKAASEKESNFIEILLTRLLVRPDAAPLFSQLVHLFGRSLQDSMLLHAKWFLVGPDVLVGRKTVRQRLHNIAESKKLSSKTQYWEPWGWCSPCTDPGTIKGDKKKFDAASLEEGEVVDEGIDMKKSLKRLSHVSQVFDSESSRINQQHVTERALIELLLPCIYQSSDESRNSFANDMIKQLCSIEGHIAAVTGGVKPVGSTPPGVEGQTNKVNTKKGIRGGSPGLARRPAGATDSSPPSPAALRVSVSLRLQLLLRFLPILCTEREPSVRNMRNSLAPVILRLLGSRVVYEDAYILSNAVHSKKDLELSSEAAASAFVDFSAEGLFDRLLLVLHALLSSYPASWLRLKPGSKSINEPTKEVSGFDREFLERMQNDLDRMQLPDTIRWRIQAAMPVLFPSTQSSFSCQPPLVPTSAVVCLQASNTIPGFNSSSSANPPLRSPVLSRVAANTSAKSKQQDSELDIDPWTLLEDGAGSCPSASNIASIGGGDHTNVRAASWLKGAVRVRRTDLTYVGAVDDDS
Length2262
PositionKinase
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.07
Grand average of hydropathy-0.251
Instability index52.23
Isoelectric point9.07
Molecular weight250504.94
Publications
PubMed=22089132
PubMed=24767513
PubMed=30397259

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28530
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     342.83|      86|     571|     252|     345|       1
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  252-  337 (141.22/68.81)	KVTYLNQVR.PGSV..GISSGTADK...IQPSRTEIWTKD..VIHYLQTLLDEFFSKNNSHSTL.QNR..ERSP..QMPYAGTLLH..KSDPLSSFSAGEE
  796-  893 (103.72/47.59)	KLPTLKRKRnPASSkdGTSTVSTDQwktVQSTASSKSAKDgaSMEELKETISVLLQLPNSLSNL.NSTgcDESE..SSVRKPTWPHygKTEPVEGTPGCEE
  920-  998 (97.89/56.53)	K.KGLKSTE.PLKV..DQPQKTTKQ...VTKSRQKNVRKM..SLAQLAASRIE.GSQGASTSHMcENK..VSCPhhRTPVDGDALR..SVDSM........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     143.37|      45|     571|    1511|    1565|       2
---------------------------------------------------------------------------
 1511- 1565 (59.49/59.93)	WFRLLIGNcRSLCEGLAvDLLGEPSiSALSRMQRMLPlSLIFPPAysifafVRWR
 2086- 2130 (83.89/47.22)	WLRLKPGS.KSINEPTK.EVSGFDR.EFLERMQNDLD.RMQLPDT......IRWR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     238.36|      77|     571|    1271|    1367|       3
---------------------------------------------------------------------------
  481-  565 (116.34/64.92)	AAGKIKNSSDYFGRIVLCIQKRAEDLAKAASPGNPSHCLAKVakaldnSLVLGDLREAYKFLfEDFcDGTVSESWIVKV..SPC.LRL
 1286- 1365 (122.02/82.95)	ALEKWDNGYQIAQQIVMGLIDSIKQTGGAAQEGDPSLVLSAV......SAIVGSVGPTLAKM.PDF.SSSNNQSNIMSLnyARCiLRM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     118.78|      37|     854|    1117|    1182|       5
---------------------------------------------------------------------------
 1134- 1174 (56.24/77.84)	SLRRYENILvaadLIPEALSSTMHRAATLIASNGRVSNSGA
 1462- 1498 (62.54/25.37)	SLERMVTIL....RLKEGLDVIQCIRTTRSNSNGNVRSVGA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     185.20|      60|    1548|     181|     250|       7
---------------------------------------------------------------------------
  181-  250 (88.45/70.54)	LS.GLQLAKPGifPElRPCGEDfRKKWIEGLsqpHKRLCTLADHVPHGykrSSLLEVLIRN..NVPLLRATWF
 1731- 1793 (96.75/49.63)	LSdAIQLASPG..PD.KAASEK.ESNFIEIL...LTRLLVRPDAAPLF...SQLVHLFGRSlqDSMLLHAKWF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      96.72|      31|     318|     684|     717|       9
---------------------------------------------------------------------------
  684-  717 (45.63/51.74)	VVHKGEGLKRLHlFIVEliRAGIFYPLAYVRQLI
 1006- 1036 (51.09/43.02)	IVFIGKALKKLR.FVEK..RAVAAWLLTVVKQVI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     133.39|      41|    1548|      78|     122|      16
---------------------------------------------------------------------------
   78-  122 (71.75/53.47)	QLNINPYKLKCDK.EPLNSRLgapdFLPQTPNC..PEETLTKEYLQ..SG
 1628- 1673 (61.65/36.24)	ELNGSDMHLKSMAfVPLRSRL....FLDAMIDCkmPPSIFTKDDVNrvSG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28530 with Med12 domain of Kingdom Viridiplantae
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