<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28520

Description RNA polymerase II transcription mediators protein
SequenceMQRYHAGSCTSAVNNNTIGGPSARDIGRIDSSSLPPNFPVSSRRLPPPFTLYKLKCDKEPLNSRLGPPDFNPQTPNCPEETLTKEYLQSGYRDTVEGLEEAREILLTQIPHFNKTIVLNCKEAIRKRLRAINESRVQKRKAGQVYGVALSGSQLSKPGVFPEQRPCSEDFRKKWIEGLSQQHKRLRSLADHVPQYRRKSVLEVLIRNNVPLPRATWFVKVTYLNLVRSGSASVPSGGTNDKTQLSCSELWTKDIIEYLQTLLDDFFSKNTSHSIHNRDRSPQIPYMTSVKHRSNQLLPVSNGEEPSLHFRWWYVVRLLQWHHAEGLLLPSLVIDWVLRQLQEKQLLEIWQLLLPIVYGFLEIVVLSQTYVRTFAGVALRIIRDPAPGGSDLVDNSRRAYTTAALIEMLRYLILAVPETFVALDCFPLPSSVVSLAINDGNFAPKAIEAADKIKSSSADVCIFRSKGLDVRYESLAFDRVISSIQKHAENLTKAVSPGYPGHCLAKAAQALDKSLVLGDLCEAFKYLFEDLYDEPASDDWVAKVSPCLRLSLKWFANVNTSLIYSVFFLCEWATCDFRNFRTAPPCDIKFTGKKDISQVHIAVRILKMKLRNMHTLSTQMNGSTHHGAGYLAKCSSQQNNWNYGCKIKSSSKTMNQIIRSSIAFESPGPLHDIIVCWIDQHIVHKGEGLKRLHLFIVELICAGIFYPLAYVRQLIVSGIMDTSVNMVDLERQKRHRRIVKQLPGNFIRHALEESKIIEGPLLIEALHDYLNERRLILRGSFSENHDNASSANGFAVNQKHCTSSAKDGSSTVSIDQRKTIPSSKISYKAEKDGNGVDDLKKAISVLLQLPKSLSNLTITGLGESQGSVKRPFRCHNKIDVMEATPGCEECRRAKKQKLSEERSSFVQAHFPVLSDDEDTWWVKKELKPLEPLKVEQPLKTTKQVAKSRQKTVRKTQSLAQLAASRIEGSQGASTSHVCDIKVNCPHHRTAMDGDTTKFVDGIQTSQFEDIVSTGRALKRLRFVEKREITVWLMTVIRQLIGDTEKSIGKVGQFGRPVTTVDDRSSIRWKLGEDELSAILYLMDISDDLVPAIKFLLWLLPKVCSSPNSTSHSGRNVSMLPRNVDNQVCNVREAFLLSSLRRYENILATSDLIPEALSSVVQRATTIIASNGRVSGSGALAFARYLLKKYSNVVSVIEWEKNFKTTCDKRLASELEFGGRLVDAECGLPLGVPAGVEDPDDYFRQKISGGRLPSRVASGMRDVVQRNVEEAFHYLFGKDRKLFAAGTPKGPTLEKWDNGYQIAQQIVMGLMDCIRQTGGAAQEGDPSLVTSAVSAIVGSVGPSLAKLPDFSAGNNHPNASLATSSLSYAKCIMRMHITCLCLLKEALGERQSRVFDIALATEASNTLAGVFAPSKASRNQFQMSPETHDTSATMSNDAVNSSSKIVLARTTKIAASVSALIVGAIIYGVTSLERMVTVLRLKEGLDVIQFVRSSRSNSNGSARSVGAIKVDCSVEVHLHWFRLLVGNCRTICEGLVVDLLSEPSIVALSRMQRMLPLSLVFPPAYLIFAFVMWRPFIMNANVAIREDTNQLYQTLTTGINDAIKHLPFRDACLRDSQGLYDLMAADTSDLEFATFLELNGSDMRLNSTAFVPLRARLFLNAIIDRKMPQSIYTKDGGSQISGHGESKIQFTDSKSKLEDKLVDVLEALQPAKFHWQWVELRLLLNELSLIEKLQTHDMSLAKAIQLSSPSPEKAAASENENDFIQIILTRLLVRPDAAPLFSELIHLFGKSLVDSMLSQAKWFLVGQDVLVGRKTIRQRLINIAESQRFSIKPQFSEPWGWCSPCTDPITIKRDKRKVDSLSLEEGEVAEGVDVKRPLKGFSQVFDSEGSTIKQLHETERAFLELILPCIDQSSDESRYSFASDLINQLCSIEKLIAAVTRGPGKLAVSSPVTEGLTNKVNTRKTIKGGSPGLARRPTSSTDSSPPSPAALRASLSLRIQLIMRFLPILCTDREPSVRKMRNTLASVILRLLGSQVVLEDANILVNATHSSHSKRDVESPSNVACVAFLDSSVEGLFDQLLLILHGLLSSSPPCWLRLKAASKTANEPTRELLETLQNHLDCMQLPDSIRLRIQAAMPVLPPSTRCSFSCQPPSVANSSLASLQSNIKNSGSNSGSLATSQRSPVPLSRTAASGKSKQQDNDFEVDPWTLLEDGAGSCPSASNVGSGDRVNIRAASWLKGAVRVRRTDLTYVGPVDEDS
Length2257
PositionKinase
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.07
Grand average of hydropathy-0.202
Instability index48.00
Isoelectric point8.98
Molecular weight250235.16
Publications
PubMed=22089132
PubMed=24767513

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28520
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     376.27|     122|     740|      73|     200|       1
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   73-  200 (192.77/132.81)	QTPNCPEETLTKEYLQSGyrDTVEGLEEAREILLtQIPH..FNKTIV.LNCKE.AIRKRLRAINESRVQKRKAGQVYGVALSGSQLS..KPGVFPEQRPC.SEDFRKKWIEglsQQHKRLRSLADHVPQYRRKSV
  815-  943 (183.50/110.16)	QRKTIPSSKISYKAEKDG..NGVDDLKKAISVLL.QLPKslSNLTITgLGESQgSVKRPFRCHNKIDVMEATPGCEECRRAKKQKLSeeRSSFVQAHFPVlSDDEDTWWVK...KELKPLEPLKVEQPLKTTKQV
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.21|      24|     744|     521|     553|       2
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  521-  553 (36.22/41.60)	EAFKYLFE...DLYDEPASDdwvakvSPCLRlslKW
 1268- 1294 (41.99/24.37)	EAFHYLFGkdrKLFAAGTPK......GPTLE...KW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     119.12|      39|     196|     451|     492|       5
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  451-  492 (62.08/57.93)	KIKSSSADVC.IFRSkglDVRYESLA..FDRVISSIQKH....AENLTK
  645-  690 (57.04/43.44)	KIKSSSKTMNqIIRS...SIAFESPGplHDIIVCWIDQHivhkGEGLKR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     232.41|      60|     827|    1306|    1365|       6
---------------------------------------------------------------------------
 1306- 1365 (103.67/57.72)	MGLMDCIRQTGGAAQEGDPSLVTSAVSAIVGSV.GPSLAKLPDFSAGNNHPNASLATSSLS
 1967- 1994 (30.40/11.24)	..............................GS...PGLARRPTSSTDSSPPSPAALRASLS
 2121- 2181 (98.34/54.33)	MQLPDSIRLRIQAAMPVLPPSTRCSFSCQPPSVaNSSLASLQSNIKNSGSNSGSLATSQRS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     109.19|      36|      62|     219|     259|       9
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  219-  259 (50.74/46.26)	KVTYLNLVRSGSAS.VP.SGGTNDKTQLscsELWTkdIIEYLQ
  282-  319 (58.45/36.70)	QIPYMTSVKHRSNQlLPvSNGEEPSLHF...RWWY..VVRLLQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     433.82|     150|     199|    1384|    1547|      10
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 1384- 1547 (212.55/188.87)	ALGERQSRVFDiALATEASNTLAGV.F..APSKASRNQFQ.MSPETHDTS.ATMSNdaVNSSSkIVLARTTKIAASvSALIVGAIIYgvtslERMVTVLRLKEGLDVI........QFvrsSRSNSNGSARSVGAIKVDCSVEVHLHW..FRLLVgNCRTICEGLVVDLLSEPSIVALS
 1581- 1745 (221.27/153.07)	AIREDTNQLYQ.TLTTGINDAIKHLpFrdACLRDSQGLYDlMAADTSDLEfATFLE..LNGSD.MRLNSTAFVPLR.ARLFLNAIID.....RKMPQSIYTKDGGSQIsghgeskiQF...TDSKSKLEDKLVDVLEALQPAKFHWQWveLRLLL.NELSLIEKLQTHDMSLAKAIQLS
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28520 with Med12 domain of Kingdom Viridiplantae
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