<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28504

Description "Mediator of RNA polymerase II transcription subunit 15a, putative"
SequenceMDSNNWVPNQGTEATADTVDWRTQLQPDQRQRIVNKIMDTLRKHLPVSGSEGLLELRKIAQRFEDKIYTAATSQSDYLRKISMKMLTMENKSQNTMANNMLSNEGGPSNNLPDQGQQHPNPLPNQHQPRQQLLSHNIQNNVAPQPNLSSVSTLPQIPSQNISQNSNTQQPGQNSVSNSIGQNSNVQSMFPGSQRQMSGRPQVVPQQQQQQSQNQQQTLYQQQLLKHKLSQMQQQQQQQNLLQPNQLLSSQQSVIPTSSAMQPSMVQSSLSSLPQNQQSNNVQQSTQSRLQQHSQIIRQQQQNSIVNQQQTPMIQQQHQQLAGPQSNATNGQHAQMLGQQNNVGDVQKSQRLHPQQNNLMNLQQRQQQQQLMNHQNNLTNIHQQPGNNVQGLQQQQQFGTESGNQGIQTSHHSAQMLQQPKVSMQQQLQHNPSKLLPSQSQQSQTQASQQQLMSQIHNQPAQMQQQLGLQQQQNPLQRDMQQKLQASGSLLQQQSVLDQQKQLYQSQRALPETSTTSVDSTTQTAQPNGVDWQEEIYQKLQTMKETYLPEINEIYQKISMKVHQFDSIPQQPKSDQIEKLKGYKTMFERMISILQIPKSSIQYGVKEKLGSYEKQIAAAINQFRPRKAMSSLQPGQLPATHMALMPQSQSQVTSVQSHENQMNSQMQPTNLQGSTSVQQNNIASLQNNSMSSLSTTQQNMLNTIQPSNNLDSGQGNSVNSLQQVPVSSLQQNTVNTQHTNINSLPSQGGVNVIQPNLNTHQPGSNMLQQQQLKHQQEQKMLQNQQFKQQYQQRQMMQRQQQQLHQPAKQQMSAQPQTHQLPQINQMNDMNDVKIRQGLGVKSGVFQQHLTSGQNSTYSHQQMKQGSPFQVSSPQLFQAASPQIPHNSSPQVDQQTHLLSLTKVGTPLQSSNSPFGVPTPSPPMAPSPMLVDSEKPIPGVSSSNAANVGQNAAAPAQSLAIGTPGISASPLLAEFSGPDGTFCNALGAPSGKSTADHPIDRLIRAVQSMSTETLTAAVSDISSVVSMSDRISGSAPGNGSRAAVGEDLVSMTNCRLQARSFITQDGGTTNGIRKFKRHIRGKTLDVGSSAGSMNDNLKQLSASEASQQESTATSNVKKPKAEVNHALLEELQQINRRLIDTIVDISTEDVDSTAAAAAAAEWVHGTIVKCSFIPVSLSPSLKSQYVSLQSPIQPLRLLVPPNYPNCSPIFIDKFPVESRKGNEDLSEKAKVKFSMSLRNLSQPMSLKDIAMTWDASVRGVISEYAQQFGGGTFSAKYGDWQEFTSWEDLLAA
Length1290
PositionTail
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.03
Grand average of hydropathy-0.822
Instability index64.61
Isoelectric point9.29
Molecular weight142831.52
Publications
PubMed=22089132
PubMed=24767513
PubMed=30397259

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
chromatin DNA binding	GO:0031490	IBA:GO_Central
transcription coactivator activity	GO:0003713	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28504
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     795.50|      73|      74|     373|     445|       1
---------------------------------------------------------------------------
  120-  168 (60.04/10.25)	..NPLPNQH.QP...........RQQLLSHNI..QNNV...AP..............Q..P.NLS.SV..S.......T...LPQ.....IPSQniSQ...NSNTQ
  171-  217 (68.35/12.76)	GQNSVSNSIGQ.NSNVQ..SM.....F...PG..SQ..........R.....QMS.GR..P.QVV.PQ..Q.......Q...QQ.........Q..SQ...NQQQT
  226-  290 (75.75/15.00)	HK..LSQMQQQ..QQQQ..NLLQPNQLL..SS..QQSV.ipTSSAMQ....PSMV.QS..S.LSS.LP..Q.......N...QQSNNVQ....Q..ST...QSRLQ
  300-  369 (79.33/16.09)	QQNSIVN..QQQTPMIQ....QQHQQL...AG..PQSN...ATNGQH....AQMLgQQ..N.NVGdVQksQ.......R...LHPQQNNLMNLQ..QR...QQQQQ
  373-  445 (137.16/33.58)	HQNNLTNIHQQPGNNVQ..GLQQQQQFGTESG..NQGI...QTSHHS....AQML.QQ..P.KVS.MQ..Q.......Q...LQHNPSKLLPSQ..SQ...QSQTQ
  448-  522 (79.92/16.26)	QQQLMSQIHNQPAQMQQqlGLQQQQNPLQRDM..QQKL...QA...S....GSLL.QQ..Q.SVL.DQ..Q......kQ...L.YQSQRALPET..STtsvDSTTQ
  524-  580 (47.74/ 6.53)	AQPN...............GVDWQ.....EEI..YQKL...QTMKETylpeINEI.YQ....KIS.MK.vH.......Q...FDSIPQQ..PKS..DQ...IEKLK
  656-  697 (51.36/ 7.62)	SHENQMNSQMQPT.NLQ..G........STS......V..................QQ..N.NIA.............S...LQNNS...MSSL..ST...TQQ..
  698-  750 (50.63/ 7.40)	..NMLNTI..QPSNNLD..SGQ.........G..N...........S....VNSL.QQ.vP.VSS.LQ..Q.......NtvnTQHTNINSLPS........QGGVN
  752-  815 (87.96/18.70)	IQPNL.NTH.QPGSN.....MLQQQQLKHQQE..QKML...QNQQFK....QQYQ.QR..Q.MMQ.RQ..Q.......Q...QLHQPAK....Q..QM...SAQPQ
  817-  889 (57.27/ 9.41)	HQ..LPQINQM..NDMN..DVKIRQGLGVKSGvfQQHLtsgQNSTYS....HQQM.KQgsPfQVS.SP..QlfqaaspQ...IPHNSS...P.............Q
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.68|      38|      40|     920|     957|       2
---------------------------------------------------------------------------
  920-  957 (66.36/36.82)	PPMAPSPMLVDSEKPIPGVSSSNAANVGQNAA.APAQSL
  962- 1000 (63.33/34.80)	PGISASPLLAEFSGPDGTFCNALGAPSGKSTAdHPIDRL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.59|      13|      36|       1|      13|       3
---------------------------------------------------------------------------
    1-   13 (26.13/16.66)	MDS.NNWVPNQGTE
   38-   51 (19.45/10.37)	MDTlRKHLPVSGSE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     129.54|      41|      47|    1028|    1074|       4
---------------------------------------------------------------------------
 1028- 1074 (65.76/52.17)	RISGSAPGNGSRAAvgedlvSMTNC..RLQARSFITQDGGTTNGIRKFK
 1076- 1118 (63.78/38.48)	HIRGKTLDVGSSAG......SMNDNlkQLSASEASQQESTATSNVKKPK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      34.07|      11|     555|      70|      95|       7
---------------------------------------------------------------------------
   56-   66 (19.44/17.66)	LRKIAQR...FEDK
   78-   91 (14.63/14.47)	LRKISMKmltMENK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28504 with Med15 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) KAMSSLQPGQLPATHMALMPQSQSQVTSVQSHENQMNSQMQPTNLQGSTSVQQNNIASLQNNSMSSLSTTQQNMLNTIQPSNNLDSGQGNSVNSLQQVPVSSLQQNTVNTQHTNINSLPSQGGVNVIQPNLNTHQPGSNMLQQQQLKHQQEQKMLQNQQFKQQYQQRQMMQRQQQQLHQPAKQQMSAQPQTHQLPQINQMNDMNDVKIRQGLGVKSGVFQQHLTSGQNSTYSHQQMKQGSPFQVSSPQLFQAASPQIPHNSSPQVDQQTHLLSLTKVGTPLQSSNSPFGVPTPSPPMAPSPMLVDSEKPIPGVSSSNAANVGQNAAAPAQSLA
2) LRKISMKMLTMENKSQNTMANNMLSNEGGPSNNLPDQGQQHPNPLPNQHQPRQQLLSHNIQNNVAPQPNLSSVSTLPQIPSQNISQNSNTQQPGQNSVSNSIGQNSNVQSMFPGSQRQMSGRPQVVPQQQQQQSQNQQQTLYQQQLLKHKLSQMQQQQQQQNLLQPNQLLSSQQSVIPTSSAMQPSMVQSSLSSLPQNQQSNNVQQSTQSRLQQHSQIIRQQQQNSIVNQQQTPMIQQQHQQLAGPQSNATNGQHAQMLGQQNNVGDVQKSQRLHPQQNNLMNLQQRQQQQQLMNHQNNLTNIHQQPGNNVQGLQQQQQFGTESGNQGIQTSHHSAQMLQQPKVSMQQQLQHNPSKLLPSQSQQSQTQASQQQLMSQIHNQPAQMQQQLGLQQQQNPLQRDMQQKLQ
3) MDSNNWVPNQGTEATADTVDWRTQLQPDQRQRIVNKIMDTLR
4) QLYQSQRALPETSTTSVDSTTQTAQPNGVD
626
78
1
501
958
484
42
530










Molecular Recognition Features






MoRF SequenceStartStop




1) IRKFKRHIR
1070
1078