<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28491

Description Cyclin-dependent kinase
SequenceMADGNRSNSNKPEWLQQYDLIGKIGEGTYGLVFLARIKSTTNRGKSIAIKKFKQSKDGDGVSPTAIREIMLLREITHENVVKLVNVHINHTDMSLYLAFDYAEHDLYEIIRHHRDKVNQSINQYTVKSILWQLLNGLNYLHSNWIVHRDLKPSNILVMGDGEEHGVVKVADFGLARIYLAPLKPLSENGVVVTIWYRAPELLLGAKHYTSAVDMWAVGCIFAELLTLKPLFQGAEVKATPNPFQLDQLDKIFKVLGHPTLEKWPSLAHLPHWNQDTSHIQGHKYDNASLNSVVHLSPKSPAYDLLSKMLEYDPKRRITAAQAMEHEYFKMEPQPGRNALVPCQPGEAFVNYPTRPVDTTTDFEGTTNMQQSQPVSSGAAIAGNMPGGHASNRSVPRPINVGMQRMHQLQAYNLTSQAGMSSGINPAGIPMQRGVPQQAHQQQQLRRKDPMGMPGYPPQQKSRRM
Length464
PositionKinase
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.08
Grand average of hydropathy-0.464
Instability index43.51
Isoelectric point9.18
Molecular weight52082.95
Publications
PubMed=22089132
PubMed=24767513
PubMed=30397259

Function

Annotated function 
ECO:0000256	
ECO:0000256
GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
cyclin-dependent protein serine/threonine kinase activity	GO:0004693	IBA:GO_Central
RNA polymerase II CTD heptapeptide repeat kinase activity	GO:0008353	IBA:GO_Central
GO - Biological Process
protein phosphorylation	GO:0006468	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats
>MDP28491
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     150.73|      39|      40|     344|     382|       1
---------------------------------------------------------------------------
  310-  342 (43.32/24.15)	......EYdPK.RRITAAQAME.HEYFKMEPQP...GRNALV.PC
  344-  382 (68.02/41.85)	PGEAFVNY.PT.RPVDTTTDFE.GTTNMQQSQP..VSSGAAI.AG
  385-  422 (39.38/21.32)	PGGHASNR.SVpRPIN......vGMQRMHQLQAynLTSQAGMsSG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.00|      25|      42|     161|     185|       2
---------------------------------------------------------------------------
  161-  185 (43.59/30.50)	GEEHGVVKVADFGLARIY..LAPLKPL
  204-  230 (41.41/28.64)	GAKHYTSAVDMWAVGCIFaeLLTLKPL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28491 with CDK8 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ALVPCQPGEAFVNYPTRPVDTTTDFEGTTNMQQSQPVSSGAAIAGNMPGGHASNRSVPRPINVGMQRMHQLQAYNLTSQAGMSSGINPAGIPMQRGVPQQAHQQQQLRRKDPMGMPGYPPQQKSRRM
338
464










Molecular Recognition Features






MoRF SequenceStartStop




1) KSIAIKKFK
2) QLRRKDPMGMPGYPPQQKSRRM
45
443
53
464