<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28480

Description ATP-dependent DNA helicase RecQ family protein
SequenceMQQQQRQSNSVQIPQHNWLKHVNSHNNFSSQPQFLTSNFLFTLPTNKPIDRAATTTSIVRQGQNVQSSQRAQVDKAWSALSRLQLSSRSYVPIGKSVKVTPQFHENRTTTSFQGSYENNKLNHPDVAATPTVINHTSRVVDSLVNNHTKYTGQTNESTKCVADTINIDDDDILESMDLDQIVEKYQSTCTPQPPMSKFPPFTPTADKDNFAGQGDTFLPPELCLNCIHGYKLGICPEAASHLQEFKDNLIAISNELIDNVENLSSVQIAKLRQDRSQLNNQIQQLEKYIHSSNLEEERQKSNFVTSMAPPTSFVYETPQRNVISSGPVISSGLNRYDDQVYMDYGTYGTSYQSSCGMPSGPVEREPFIPKIIEVNYIEGSGDKRWSSRDFSWTKELEVNNKKVFGNHSFRPNQREVINATMSGCDVFVLMPTGGGKSLTYQLPALINPGITLVISPLVSLIQDQIMHLLQANIPAAYLSANLEWAEQQEILRELNSDYCKYKLLYVTPEKVARSDVLLRQLESLHGRELLSRIVIDEAHCVSQWGHDFRPDYQGLGVLKQKFPNTPVLALTATATASVKEDVVQALGLVNCVVFRQSFNRPNLWYSVVPKTKKCLEDIDKFIRENHFDECGIIYCLSRMDCEKVAEKLQECGHKCAFYHGSMDPDQRAHVQRQWSKDEINIICATVAFGMGINKPDVRFVIHHSLPKSVEGYHQECGRAGRDGQRSSCVLYYSYSDYIRVKHMLSVGAVEQSNMTSGYSRFNATNSGRLLETNTENLLRMVSYCENDVDCRRLIQLVHFGEKFDSSNCHKTCDNCVKITSFVEKDVTEIAKQLVELVKLTGQKVSASHILEVYRGSLSQMVKKHRHETVRLHGAGKHLAKGEASRILHHLVVEDFIAEVVKKSDFYGSVSSVLKVNEQKVRNMLFGGQRIILRFPSSVKASKPGKCDSISAKGSLASAKLNLPIDIPDQPETEIDLDLSAKLYTALRMLRTTLCREAGEGVMAHHIFGNATLQQISKKLPRTKEELLDINGISKTKVSKYGDRLLETIAKTINEYYNTDKNSSGSKGSVDSAKRRREANRTPDSNGEDDDALIKSTGRSKKRTVKRQIKKAEIYESEEEDYYHGCLDEDLDCIDIDNVVLDKLTGTNAAGRVLPQWTAS
Length1159
PositionUnknown
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.07
Grand average of hydropathy-0.492
Instability index42.74
Isoelectric point7.35
Molecular weight130330.89
Publications
PubMed=22089132
PubMed=24767513
PubMed=30397259

Function

Annotated function 
GO - Cellular Component
chromosome	GO:0005694	IBA:GO_Central
cytoplasm	GO:0005737	IBA:GO_Central
nucleus	GO:0005634	IBA:GO_Central
plasmodesma	GO:0009506	IEA:EnsemblPlants

GO - Biological Function
3'-5' DNA helicase activity	GO:0043138	IBA:GO_Central
ATP binding	GO:0005524	IEA:UniProtKB-KW
four-way junction helicase activity	GO:0009378	IBA:GO_Central
nucleic acid binding	GO:0003676	IEA:InterPro

GO - Biological Process
cellular response to abscisic acid stimulus	GO:0071215	IEA:EnsemblPlants
cellular response to cold	GO:0070417	IEA:EnsemblPlants
DNA duplex unwinding	GO:0032508	IBA:GO_Central
DNA recombination	GO:0006310	IBA:GO_Central
DNA repair	GO:0006281	IBA:GO_Central
DNA unwinding involved in DNA replication	GO:0006268	IBA:GO_Central
double-strand break repair via homologous recombination	GO:0000724	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28480
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     253.02|      85|     113|     870|     959|       1
---------------------------------------------------------------------------
  870-  959 (129.03/100.31)	RLHGAGKHLAKG...EASR..ILHHLVVEDFIAEVVKKsdFYGSVSSVLKVN...EQKVRNMlfgGQRIILRFPSSVKASKPGKCDSISAKGSLASAK
  981- 1073 (123.98/82.30)	KLYTALRMLRTTlcrEAGEgvMAHHIFGNATLQQISKK..LPRTKEELLDINgisKTKVSKY...GDRLLETIAKTINEYYNTDKNSSGSKGSVDSAK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.02|      18|     113|     173|     203|       2
---------------------------------------------------------------------------
  173-  190 (32.11/11.65)	LESMDLDQIVEKYQSTCT
  342-  356 (24.24/ 7.34)	...MDYGTYGTSYQSSCG
  636-  652 (30.67/ 8.30)	LSRMDCEKVAEKLQ.ECG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      82.15|      21|      25|     782|     802|       3
---------------------------------------------------------------------------
  782-  802 (39.15/26.62)	SYCENDVD..CRRLIQLVHF.GEK
  806-  818 (18.43/ 8.49)	SNCHK..T..CDNCVKI.......
  820-  843 (24.57/13.86)	SFVEKDVTeiAKQLVELVKLtGQK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.81|      20|      24|     477|     496|       4
---------------------------------------------------------------------------
  477-  496 (33.13/26.95)	YLSANLEWAEQQEI......LRELNS
  498-  523 (26.67/20.00)	YCKYKLLYVTPEKVarsdvlLRQLES
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.39|      22|      28|     655|     676|       8
---------------------------------------------------------------------------
  655-  676 (44.50/32.64)	CA...FYHGSMDPDQRAHVQRQWSK
  683-  707 (35.89/24.73)	CAtvaFGMGINKPDVRFVIHHSLPK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28480 with Med34 domain of Kingdom Viridiplantae
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