<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28471

Description Mediator of RNA polymerase II transcription subunit 33A
SequenceMEISMRRSMEEVTKEAQEKGSDPLAWALEMYSNLNSSGKSVPSSELAEFLVSYICWDNNVPIIWKFLEKALILNIVPPMLLLALLSVRVIPCRHAQPAAYRLYLELVKKHTFELKSQISRPDYQKDMKSIDAVLHLSKIFGMSQSEPGIVVVEFIFSIVWQLLDASLDDEGLLEFTQEKKSRWAMLYQEMELDGRNNYTEQIENLRSINTLIAVEMIGKFLQDKVSSRILCLARRNLPAHWLSFVQRLQLLSTNSLALRKSKTLSPEALLHLTSDACMVLSKECKTHSQQKFRKVMAFEYLSSSASLCHGASHSALWIPLDLVLEDTMDGYQVSATSAVEEISGLIKTLRAINGTSWYDTFLGLWFASLRLVQRERDPIEGPMPHLETRLCMLLCIIPLVVANFIEEDEEEEQTTIDEKDGDPTDQWKEKRFPGKCRNDLVSSLQVLGDYQSLLTPPQSVIAAANQAAAKAMLFISGIAIGSAYYDCLTMAEMPVDCSGNMRHLIVEACISRNLLDTSAYLWPGYANGHINQIPQCMPAQVPGWSSFLKGAALTSGMVNALVSSPATSLAELEKIFEIAIAGSEDEKISAATILCGASLIRGWNIQEHTVHFILRLLSPPVPIENMEGNNYLINYAPILNVLFVGISSIDCIQVFSLHGLVPQLACSLMPICEVFGSCMPNISWKLTSGEEISAHAVFSNVFILLLKLWKFNCPPLEHGIGDTPSVGSQLTPEYLLLVRNSQLMSAGNIRKDRNRRRLSEIASLSSPNSVFVDSFPKLKVWYRQHQACIASTLSGLVHGTPFHQIVEGLLNMMFRKINRGNQPTITTGSSSSSGLGNEDASIGPKLPAWDILEAIPFVVDAALTACSHGRLSPRELATGLKDLADFLPASLATIISYFSAEVTRGVWKPAFMNGTDWPSPAANLQNVEEQIKKILAETGVDVPSLASGDSSPATLPLPLAAFTSLTITYKVDRSSERFLHLAGQTLEGLAAGCPWPCMPIVASLWTQKAKRWSDFLIFSASRTVFLHNSDAVVQLVKRCFTATLGMSSSPISSSGGVGALLGHGFKSNLCGGICPVAPGILYLRAYRSVRDIVFLTEEIVSILMQSVREIVCGVLPKQRLKKLKLTKDGIKYGQVSVAASMTRVKLAAALGASLVWISGGLTLVQLLINETLPSWFISVQRSDQEEKSNGMVAMLGGYGLAYFAVLCGAFAWGVDSSSSASKRRPKVLGTHMEFLASALDGKISLGCDPATWRAYVSGFVSLMVGCIPNWVLEVDVNVLKRLSNGLRQLNEEELALALLGVGGVGTMGAAAELIIDTEM
Length1319
PositionTail
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.08
Grand average of hydropathy0.150
Instability index46.92
Isoelectric point6.06
Molecular weight144591.97
Publications
PubMed=22089132
PubMed=24767513
PubMed=30397259

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28471
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     427.01|      92|     113|     646|     737|       1
---------------------------------------------------------------------------
  646-  716 (109.34/57.50)	.................................................I.S...SIDCIQVFSLHG.LVP.QLA...........CSLMPICEVFGSCMPNIS..WK..LTSGEE.ISAHAVFS...NVFI....LLL.KLWKFNCPPL
  717-  825 (108.04/56.73)	EHGIG.DTPSVGS.QLTPEYLLLvrnsqlmsagnirkdrnrrrlseiasL.S...SPNSVFVDSF.....P.KLK...........VWY....RQHQACIASTL..SG..LVHGTP.F..HQIVE...GLLN....MMFrKINRGNQPTI
  832-  936 (82.94/41.87)	SSGLGnEDASIGP.KL.PAWDIL.......................eaiP.F...VVDAALTACSHGrLSPrELAtglkdladflpASLATIISYFSAEVTRGV..WKpaFMNGTDwPSPAANLQ...NVEE....QIK.KILA......
  937- 1042 (100.01/51.98)	ETGV..DVPSLASgDSSPATLPL...................plaaftsL.TityKVDRSSERFLH..LAG.QTL...........EGLAAGCP..WPCMPIVAslW...TQKAKR.WSDFLIFSasrTVFLhnsdAVV.QLVK.RCFTA
 1043- 1076 (26.68/ 8.56)	TLGMS.SSP.........................................iS...SSGGVGALLGHG.FKS.NL............CG..GICPV.......................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.19|      11|      17|    1241|    1252|       2
---------------------------------------------------------------------------
 1241- 1252 (20.63/13.58)	GKISL..GCDPaTW
 1258- 1270 (20.55/ 9.03)	GFVSLmvGCIP.NW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.03|      27|     213|      92|     119|       3
---------------------------------------------------------------------------
   92-  119 (43.84/28.82)	CRHAQPAAYRLYLELVKKHTFElKSQIS
  308-  334 (50.20/29.13)	CHGASHSALWIPLDLVLEDTMD.GYQVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.22|      11|     115|     271|     284|       5
---------------------------------------------------------------------------
  271-  284 (17.53/16.15)	HLTSDACMVLskeC
  385-  395 (22.68/12.09)	HLETRLCMLL...C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.18|      18|     400|       9|      26|       6
---------------------------------------------------------------------------
    9-   26 (33.56/20.77)	MEEVTKEAQ....EKGSDPL.AW
  405-  427 (24.61/13.40)	IEEDEEEEQttidEKDGDPTdQW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28471 with Med33 domain of Kingdom Viridiplantae
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