<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28471

Description Mediator of RNA polymerase II transcription subunit 33A
SequenceMEISMRRSMEEVTKEAQEKGSDPLAWALEMYSNLNSSGKSVPSSELAEFLVSYICWDNNVPIIWKFLEKALILNIVPPMLLLALLSVRVIPCRHAQPAAYRLYLELVKKHTFELKSQISRPDYQKDMKSIDAVLHLSKIFGMSQSEPGIVVVEFIFSIVWQLLDASLDDEGLLEFTQEKKSRWAMLYQEMELDGRNNYTEQIENLRSINTLIAVEMIGKFLQDKVSSRILCLARRNLPAHWLSFVQRLQLLSTNSLALRKSKTLSPEALLHLTSDACMVLSKECKTHSQQKFRKVMAFEYLSSSASLCHGASHSALWIPLDLVLEDTMDGYQVSATSAVEEISGLIKTLRAINGTSWYDTFLGLWFASLRLVQRERDPIEGPMPHLETRLCMLLCIIPLVVANFIEEDEEEEQTTIDEKDGDPTDQWKEKRFPGKCRNDLVSSLQVLGDYQSLLTPPQSVIAAANQAAAKAMLFISGIAIGSAYYDCLTMAEMPVDCSGNMRHLIVEACISRNLLDTSAYLWPGYANGHINQIPQCMPAQVPGWSSFLKGAALTSGMVNALVSSPATSLAELEKIFEIAIAGSEDEKISAATILCGASLIRGWNIQEHTVHFILRLLSPPVPIENMEGNNYLINYAPILNVLFVGISSIDCIQVFSLHGLVPQLACSLMPICEVFGSCMPNISWKLTSGEEISAHAVFSNVFILLLKLWKFNCPPLEHGIGDTPSVGSQLTPEYLLLVRNSQLMSAGNIRKDRNRRRLSEIASLSSPNSVFVDSFPKLKVWYRQHQACIASTLSGLVHGTPFHQIVEGLLNMMFRKINRGNQPTITTGSSSSSGLGNEDASIGPKLPAWDILEAIPFVVDAALTACSHGRLSPRELATGLKDLADFLPASLATIISYFSAEVTRGVWKPAFMNGTDWPSPAANLQNVEEQIKKILAETGVDVPSLASGDSSPATLPLPLAAFTSLTITYKVDRSSERFLHLAGQTLEGLAAGCPWPCMPIVASLWTQKAKRWSDFLIFSASRTVFLHNSDAVVQLVKRCFTATLGMSSSPISSSGGVGALLGHGFKSNLCGGICPVAPGILYLRAYRSVRDIVFLTEEIVSILMQSVREIVCGVLPKQRLKKLKLTKDGIKYGQVSVAASMTRVKLAAALGASLVWISGGLTLVQLLINETLPSWFISVQRSDQEEKSNGMVAMLGGYGLAYFAVLCGAFAWGVDSSSSASKRRPKVLGTHMEFLASALDGKISLGCDPATWRAYVSGFVSLMVGCIPNWVLEVDVNVLKRLSNGLRQLNEEELALALLGVGGVGTMGAAAELIIDTEM
Length1319
PositionTail
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.08
Grand average of hydropathy0.150
Instability index46.92
Isoelectric point6.06
Molecular weight144591.97
Publications
PubMed=22089132
PubMed=24767513
PubMed=30397259

Function

Annotated function 
GO - Cellular Component
integral component of membrane	GO:0016021	IEA:UniProtKB-KW
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of phenylpropanoid metabolic process	GO:2000762	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28471
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     427.01|      92|     113|     646|     737|       1
---------------------------------------------------------------------------
  646-  716 (109.34/57.50)	.................................................I.S...SIDCIQVFSLHG.LVP.QLA...........CSLMPICEVFGSCMPNIS..WK..LTSGEE.ISAHAVFS...NVFI....LLL.KLWKFNCPPL
  717-  825 (108.04/56.73)	EHGIG.DTPSVGS.QLTPEYLLLvrnsqlmsagnirkdrnrrrlseiasL.S...SPNSVFVDSF.....P.KLK...........VWY....RQHQACIASTL..SG..LVHGTP.F..HQIVE...GLLN....MMFrKINRGNQPTI
  832-  936 (82.94/41.87)	SSGLGnEDASIGP.KL.PAWDIL.......................eaiP.F...VVDAALTACSHGrLSPrELAtglkdladflpASLATIISYFSAEVTRGV..WKpaFMNGTDwPSPAANLQ...NVEE....QIK.KILA......
  937- 1042 (100.01/51.98)	ETGV..DVPSLASgDSSPATLPL...................plaaftsL.TityKVDRSSERFLH..LAG.QTL...........EGLAAGCP..WPCMPIVAslW...TQKAKR.WSDFLIFSasrTVFLhnsdAVV.QLVK.RCFTA
 1043- 1076 (26.68/ 8.56)	TLGMS.SSP.........................................iS...SSGGVGALLGHG.FKS.NL............CG..GICPV.......................................................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.19|      11|      17|    1241|    1252|       2
---------------------------------------------------------------------------
 1241- 1252 (20.63/13.58)	GKISL..GCDPaTW
 1258- 1270 (20.55/ 9.03)	GFVSLmvGCIP.NW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.03|      27|     213|      92|     119|       3
---------------------------------------------------------------------------
   92-  119 (43.84/28.82)	CRHAQPAAYRLYLELVKKHTFElKSQIS
  308-  334 (50.20/29.13)	CHGASHSALWIPLDLVLEDTMD.GYQVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.22|      11|     115|     271|     284|       5
---------------------------------------------------------------------------
  271-  284 (17.53/16.15)	HLTSDACMVLskeC
  385-  395 (22.68/12.09)	HLETRLCMLL...C
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.18|      18|     400|       9|      26|       6
---------------------------------------------------------------------------
    9-   26 (33.56/20.77)	MEEVTKEAQ....EKGSDPL.AW
  405-  427 (24.61/13.40)	IEEDEEEEQttidEKDGDPTdQW
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28471 with Med33 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




NANANA









Molecular Recognition Features






MoRF SequenceStartStop




1) LAWALEMY
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