<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28469

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMATAELGQQTVELSTLVTRAAQDSYNSLKDLVHKCSCSTELSDTDKKISMLKFLTKTRQRMIRLNVLSKWCQQLPLIQHCQQLSSTVSNHDMCFTQAADSLFFMHEGLLQARAPVYDIPSAIEILLTGSYECLPKCIDDVGSQYALTQDKQKPALKKLDMLVRSKLLEVSLPKELSDIRVSDGTAMVKVDGEFQVLLTLGYRGHMSLWRILHLELLVAEKNKPVKLEELRRHVLGDDLERRMAAAENPFSILYSVLHELCVVLVMDTVIRQVQFLRHGRWKDNPDGESDSSGLRTPGLKIIYWLDFDKNADVADSGACPFIKIEPGSDLQIKCTHSIFVIDPLTGKEAEFLLDQNCIDVERLLLRAICCNRYTRLLEIKTELLKNVQVFRTADDVVLQSRMGEPDIEHKQKDDKRCNKDSEAHEVLHVHAYGSSFFTLGISIRNGRFLLQSSQNIAVSSALLECEEALNQGSMTAAEVFLSLRSKSMLHLFASIGRVLGLEVYEHGLNTVKNPKTFFNGSTMLMMGFPDSGSSYFLLMQLDKKFNPLFKLLETEPDPSGKDNIFGDLNQVLRFKKIDIAQMQVLEDEMNLSLVDWEKLHSILSNTACPNQMSGHGLYSDIRLQNSIHTARGHHASGFSSLVDDVFGLEKGSSVPPFPVQNISSPLNTSLPFHYGSLPKAGNIQYNGSLFSSGGVKGLVQSSSVGSLLTGQGRSTVGKKLPALKSEQDLTSVKSPHSVDISSYTAMDEDTANDALSGSRPSLLSPPWPISSQMSSPSSRPNATTPVSQGPDTVNFSSSEDVISEHDKRSRKRTTSDMLNLIPSLQGFVKNQGICKRRKISDPCGSQLALRQGSITPEMIPRAEGCSYGSLIAEANKGNAPSSIYVAALLHVVRHCSLCIKHARLTSQMDALEISYVEEVGLRRESFNIWFRLPFARGDSWQHIFLRLGRPGCMYWDVKIDDQHFRDLWELQKGSSNTPWGSGVRIVNTSDIDSHIRYDPDGVVLSYQSVEEDSVKKLVADIQRLANARTFSIGIRKLLVIRADEKSEEFHTHSDVKISGVKTASDSADKLQMRRAFRIEAVGLMSLWFSFSSGVLARFVVEWESSKEGCTMHVSPDQLWPHTKFLEDFINGAEVSLLLDCIRLTAGPLHALAAATRLARAGPVPGVAAALSSFPKQAGYISLQGLLLGSLSSTANVGHPASGLGANTAVSNASGIANQTLSMLAAAGRGGPGIVPSSLSPFDVSVVHRGPYWIRIMYRKQFAVDMRCFAGDQVWLQPATPPKEGRPSGGSLPCPQFRPFIMEHVAQELNGLDPSFTGQQAGGRTSSNSPNSGTQSMAANGNRINSAAMSRTGNQVASLNSMGNALAGSSTLALTTSAVPLRRPPGTVVPAHVKGGLNTAIIGLGDDGGYGGGWVPLDALKKVLRGILKYLGVLWLFAQLPDLLKEILGSILKDNEGALLSLDPEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFHQQQQQQQQNSNPAPEELSSSEISEICEYFSRRVASEPYDASRVASFITMLTLPIPVLREFLKLIAWKKGLSQAQVGDVVSAQKPRIELCLENHAGLNADENSKSSSAFRSNIHYNRLHNSVDFALTVVLNSAHIPHVNAAGGAAWLPYCVSVSLRYSFGESLNVSFLGMSGSHGGRACWPRVDDWEKCKRRVARIVEVSASSTADVSQGRLKLVADSVQRNLHMCIQGLRDGSGATTSSGAT
Length1738
PositionTail
OrganismMedicago truncatula (Barrel medic) (Medicago tribuloides)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> rosids> fabids> Fabales> Fabaceae> Papilionoideae> 50 kb inversion clade> NPAAA clade> Hologalegina> IRL clade> Trifolieae> Medicago.
Aromaticity0.07
Grand average of hydropathy-0.161
Instability index45.46
Isoelectric point7.95
Molecular weight190400.16
Publications
PubMed=22089132
PubMed=24767513

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU365082
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central
GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28469
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     111.51|      27|      47|     644|     670|       1
---------------------------------------------------------------------------
  644-  670 (49.08/25.66)	VFGLEKGSSVPPFPVQNISSPLNTSLP
  672-  688 (20.28/ 6.44)	....HYG.SLP..KAGNIQ..YNGSL.
  694-  720 (42.15/21.04)	VKGLVQSSSVGSLLTGQGRSTVGKKLP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.13|      26|      46|    1164|    1190|       2
---------------------------------------------------------------------------
 1164- 1190 (39.12/27.53)	GVAAALSSFPKQAGYiSLQGLLLGSLS
 1213- 1238 (45.02/27.42)	GIANQTLSMLAAAGR.GGPGIVPSSLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      40.37|      12|      21|    1416|    1427|       4
---------------------------------------------------------------------------
 1416- 1427 (20.26/13.22)	DALKKVLRGILK
 1440- 1451 (20.11/13.06)	DLLKEILGSILK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.72|      13|      22|    1372|    1384|       6
---------------------------------------------------------------------------
 1372- 1384 (23.37/12.13)	LTTSAVPLRRPPG
 1395- 1407 (22.35/11.29)	LNTAIIGLGDDGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.32|      29|      46|    1008|    1036|       7
---------------------------------------------------------------------------
 1008- 1036 (45.53/35.23)	VEEDSVKKLVADIQRLANARTFSI...GIRKL
 1054- 1085 (41.79/31.61)	VKISGVKTASDSADKLQMRRAFRIeavGLMSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     124.46|      37|     669|     118|     155|       9
---------------------------------------------------------------------------
  118-  155 (61.83/42.05)	IPSaIEILLTGSYECLPKCIDD.VGSQYALTQDKQKPAL
  820-  857 (62.63/38.30)	IPS.LQGFVKNQGICKRRKISDpCGSQLALRQGSITPEM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      88.09|      26|     269|    1290|    1317|      10
---------------------------------------------------------------------------
 1290- 1317 (42.36/36.87)	LPCPQFRPFiMEHVAQElNGLDPSFTGQ
 1548- 1573 (45.74/29.81)	LPIPVLREF.LKLIAWK.KGLSQAQVGD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     224.23|      69|     159|     566|     639|      13
---------------------------------------------------------------------------
  566-  639 (108.06/75.88)	DLNQVLRFKKIDIAQMQVL.EDEMNLSLVDweKLHSILSNtacPNQMSGHGLYSDIRLQNSIHTARGHHASGFSS
  727-  796 (116.17/67.08)	DLTSVKSPHSVDISSYTAMdEDTANDALSG..SRPSLLSP...PWPISSQMSSPSSRPNATTPVSQGPDTVNFSS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28469 with Med14 domain of Kingdom Viridiplantae


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GLDPSFTGQQAGGRTSSNSPNSGTQSMAANGNRIN
2) KSPHSVDISSYTAMDEDTANDALSGSRPSLLSPPWPISSQMSSPSSRPNATTPVSQGPDTVNFSSSEDVISEHDKRSRKRTTSD
1309
732
1343
815










Molecular Recognition Features






MoRF SequenceStartStop




NANANA