<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28457

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMTSRAPPAHSAARHSSARSPVHSAAQSPKYAGQAGNVPLALSQSLTSVQSINSPSALSLASPSAGRHTFDSPVGNLLPKSTTRAKTLYTLNADTSDPRWERHLVPSAVELPFAALYAQQDKTTNGDQAWRIDWQQYRVVENDATANENLLERHGRDDMAAGPSEQSWGSRWTIVLPVDAAKPDDASARQLWSFTFAGKDAPIADPEPRAGLKVSLTGSFTHADLYPHIYKSGTVAQETPIADLPAAFSISSLSPELFLTLNAFTMAARDAFLRRLVLFETGEDMTCLRDGNGVLLLPPDQDSTWCSCQVQLAQSHLVFSPVLETSDYSSLTARHVEQMEYLQQESGSFDMADTKSAITLAPLGLSGVFVRRYAHTHPAYEHTRSRSIKQCELASLHGLRESWHDATRGLLQPLSPDAQWIVIRSIDVPGIEGERDIVWPLAACLVKPSPAEAPKPTLPLATRSQNILSMEEHLNALAQWSGAQIDQLTKTRDRKDTPTKAGDFPASPRPAAPAPSAPASASADSPRTPAAEPSKPAKVPPPPAHVQRETDWDLIESRPSPRHQHSYELEHATDPMQGLTEDDFSFFDAPTVKVSKAHINGNKPRSPDQVDQAIQHPSVSSSVGSGGTFTSFEDATSATTAPSTVSPGSDVSNVKTPKTPYWHTEDSLRSDEMKVLSPVHEVEQPHVPLTSFEAISFDDLPIAKKRPQSAVFKTLDINVSDGRKTKRRRSSISIDLAESKARYPSRARHTRLQQSIMDESAATSEDELARDGDADDDDDGVRASNSEEDDGAPIPAQLLTAEIFSLLGDRLQQKPGKTDDAVVSSALDNPAAKEHVATSFAEHLVENPDFRWVLMRNKPVAAPVASSVLPHSIVLRATDLISRLDRGTADEVTEVTDALERLDAPPLILRRRDMVIKSSPLALPNWSKLGFTPLSGCKNVTVVALHGAQQSSASVRQWLGRTAAAYSACGLGTCEVAHALAEGGARRLPTGAMDLRKGAEVAQSLIDLRQTLRQHSQSCDHLTVMLVDSMAVPAAVMSLLSFLSEPTLEQTADKHRPHPFLVHLVAPDALLRAFEISGQPGEATDETALAFRLYDRLRLEVEHRSAKPETAEALGLTAKARHGSFQGHAFTLSLERVASRPRIDFSWPSRSLDILDRHRMLHVAYAISADRRWLCLACVDDRGEGHTVRVKLLPANVQPGQTYIQACLLVWELAQGTATSASVEWRVVIVKMGLLEALELAAWERVFASAASRWSKPAHLSLLATDAKTPLLLRDTKLEQVASADSPTDSLFGPDDEELHHGKTLIDLQSRHYACILAQPSELYNHDLRLYARSLASAFMLLVPDQPTLAQSHSWPSLVRSRASKAISSLNLYYLSSHRTATSTYTSSIEATLRDITRSYSDLHTLARARWQMHDVNGLPWHLASVSLVEDFLASQISKST
Length1440
PositionKinase
OrganismMixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Mixiomycetes> Mixiales> Mixiaceae> Mixia.
Aromaticity0.06
Grand average of hydropathy-0.345
Instability index56.73
Isoelectric point6.01
Molecular weight157223.76
Publications
PubMed=21478649

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28457
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     199.87|      47|      63|     630|     677|       1
---------------------------------------------------------------------------
  505-  542 (49.53/25.15)	.....ASPRPAAPAPSAPAS...ASADSPRTP..AAEP......SKPAKVpPPP
  546-  594 (50.90/26.10)	QREtDWDLIESRPSPRHQHSyELEHATDPMQGL..TEDDFSffdAPTVKV..S.
  605-  627 (24.20/ 7.45)	SPD.QVDQAIQHPS.VS......SSVGSGGT.......................
  630-  677 (75.25/48.47)	SFE.DATSATTAPSTVSPGS.DVSNVKTPKTPYwHTEDSLR...SDEMKV.LSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     790.63|     249|     298|     813|    1076|       2
---------------------------------------------------------------------------
  402-  482 (45.95/15.53)	.........................................W.......HDATRGLLQPL..SPDAQWIVIRSID.VPGIE.GERDI.........VWP....LAACL.........VKPSPAEAPKPT....LPLatrsqnilSMEEHLNaLAQWSGA............................................................................................................................................
  813- 1076 (377.34/243.41)	KPgKTDDAV.VSSALDNPAAKEHVATSFAEHLVENP..DFRW......VLMRNKPVAAPVASSVLPHSIVLRATDlISRLDRGTADEV......TEVTDALERLDAPPLILrrrDMVIKSSPLALPNWSKLGFTPL........SGCKNVT.VVALHGAQQSSASvrQWLGRTAAAYSACGLGTCEVAH..ALAEGGARRLPTGAMDLRKGAEV..AQSLIDLRQ.....TLRQHSQSCDHLTVMLVDSMAvpAAVMSLLSflSEPTLEQTadkHrPHPFLVHLVAPDAL..LRAFEIS
 1106- 1375 (367.34/200.42)	KP.ETAEALgLTAKARHGSFQGHAFTLSLERVASRPriDFSWpsrsldILDRHRMLHVAYAISADRRWLCLACVD.....DRGEGHTVrvkllpANVQPGQTYIQACLLVW...ELAQGTATSASVEW.RVVIVKM........GLLEALE.LAAWERVFASAAS..RWSKPAHLSLLATDAKTPLLLRdtKLEQVASADSPTDSLFGPDDEELhhGKTLIDLQSrhyacILAQPSELYNHDLRLYARSLA..SAFMLLVP..DQPTLAQS...H.SWPSLVRSRASKAIssLNLYYLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     161.60|      55|     126|      55|     117|       4
---------------------------------------------------------------------------
   55-  117 (78.24/55.64)	SALSLASPS.AGRhtfDSPVGNLLPKSTTRAKTLYTL.NADTSdPrwerHLVPS...AVELPFAALYA
  186-  245 (83.36/40.31)	SARQLWSFTfAGK...DAPIADPEPRAGLKVSLTGSFtHADLY.P....HIYKSgtvAQETPIADLPA
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28457 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AQWSGAQIDQLTKTRDRKDTPTKAGDFPASPRPAAPAPSAPASASADSPRTPAAEPSKPAKVPPPPAHVQRETDWDLIESRPSPRHQHSYELEHATDPMQGLTEDDFSFFDAPTVKVSKAHINGNKPRSPDQVDQAIQHPSVSSSVGSGGTFTSFEDATSATTAPSTVSPGSDVSNVKTPKTPYWHTEDSLRS
2) MTSRAPPAHSAARHSSARSPVHSAAQSPKYAGQAGN
3) RYPSRARHTRLQQSIMDESAATSEDELARDGDADDDDDGVRASNSEEDDGAPI
477
1
741
669
36
793










Molecular Recognition Features






MoRF SequenceStartStop




NANANA