<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28448

Description Mediator of RNA polymerase II transcription subunit 7
SequenceMAGSDSGSDVEDVRAGPSNEIDGKEETSASLFPAPPSIWKRFTTRNIELAKLLDERIRAEDALQSPTQGKSKQEERSKRQARLLADELDKDEEDVADFDLLQLIRPPSVEQVYREGYWNVFGQSFPVSEEDTELPDEMRLYDPLAERKNNLEKLLQTLLLTYFKLTQALLKGPPSRAVPQPDSLYVTVPGETGEPERVERNDVDLCLQHIRYASLNMHHLLNQLRPVQARENLRVIMLQQIQARREIAASLREQARLAQAQIDVLKTRLRGTEHADMAIDPPLKGSAVEELDTSRSKRVRESHNAFVTASYPKKA
Length315
PositionMiddle
OrganismMixia osmundae (strain CBS 9802 / IAM 14324 / JCM 22182 / KY 12970)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Basidiomycota> Pucciniomycotina> Mixiomycetes> Mixiales> Mixiaceae> Mixia.
Aromaticity0.05
Grand average of hydropathy-0.688
Instability index61.37
Isoelectric point5.31
Molecular weight35747.84
Publications
PubMed=21478649

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. 
ECO:0000256	RuleBase:RU364060
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP28448
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     222.41|      60|      68|      98|     158|       1
---------------------------------------------------------------------------
   35-   87 (49.38/23.95)	..........PPS..I........WKRFtTRN.IE..LAKllderiraEDA.LQSPTQGKSKQEERSKRQARLLADE
   98-  158 (100.82/59.23)	FDLLQ.LIR.PPS..VEQvYREGYWNVF.GQS.FP..VSE........EDTELPDEMRLYDPLAERKNNLEKLLQTL
  163-  224 (72.21/37.99)	FKLTQaLLKgPPSraVPQ.PDSLYVTVP.GETgEPerVER........NDVDLCLQHIRYASL.....NMHHLLNQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      59.35|      17|      29|     268|     284|       2
---------------------------------------------------------------------------
  268-  284 (30.11/22.00)	RLRGTEHADMAIDPPLK
  298-  314 (29.24/21.16)	RVRESHNAFVTASYPKK
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28448 with Med7 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MAGSDSGSDVEDVRAGPSNEIDGKEETSAS
1
30










Molecular Recognition Features






MoRF SequenceStartStop




1) YREGYW
113
118