<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28442

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMDLAYICEWEKWPKSTHCPSGPLACTWSCRNLIAFTTDLRSDDQDLTRMIHILDTEHPWDVHSIRSEHSEAITCLEWDQSGSRLLSADADGQIKCWSMADHLANSWESPVGSVVEGDPIVALSWLHNGVKLALHVEKSGASSFGEKFSRVKFSPSLTLFGGKPMEGWIAVTVSGLVTVSLLKPSGQVLTSTESLCRLRGRVALADIAFTGGGNIVVATADGSSASPVQLYKVCVSVVNEKCRIDTELLPSLFMRCTTDLSRRDRLPAITHLKFLARDMSEQVLLCASSQTSSVVECWSLRKEGLPVNNIFQQLSPAVGDKQPTILKWRILSATNDLDRVSAVALPKLPISLTNTDLKVASDTQFYPGLGLALAFHDGSVHIVHRLSLQTMAIFYSSAAPRPIDEPALKRPRTTGPAVHFKAMQLSWTSLALVGIDNHGRLSMLRISPSMGHSLDVGLALRHLLFLLEYCMVTGYDWWDILLHVQPGMVQSLVEKLHEEYTRQKAELQQVLSTRILAMKASLCKLSPCTVTRVCDYHAKLFLIAISSTLKSLLRPHVLNTPDKSPGDRLTEICAKITDVDIDKVMINLKTEEFVLDMNTLQALQQLLQWVGDFVLYLLASLPNQGSPLRPGHSFLRDGTSLGMLRELMVVIRIWGLLKPSCLPVYTATSDTQDSMSLLFRLLTKLWICCRDEGPTSEPDEALVDECCLLPSQLLIPSLDWLPVSDGLVSRLQPKQPLRLHFGKAPALPGSSTGLQLDGLIRAPGQPKMDHLRRLHLGAYPTEACKACTRCGCVTMLKSPNKTTAVKQWEQRWIKNCLCGGLWWRMPLSYP
Length829
PositionTail
OrganismBos taurus (Bovine)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Laurasiatheria> Artiodactyla> Ruminantia> Pecora> Bovidae> Bovinae> Bos.
Aromaticity0.07
Grand average of hydropathy0.019
Instability index49.42
Isoelectric point7.89
Molecular weight91832.73
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
catalytic activity	GO:0003824	IEA:InterPro
thyroid hormone receptor binding	GO:0046966	IEA:Ensembl
transcription coactivator activity	GO:0003713	IEA:Ensembl

GO - Biological Process
positive regulation of transcription initiation from RNA polymerase II promoter	GO:0060261	IEA:Ensembl
positive regulation of transcription, DNA-templated	GO:0045893	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28442
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     704.74|     187|     348|     293|     481|       1
---------------------------------------------------------------------------
  293-  481 (314.70/170.49)	VVECWSLRKEGLPVNNIFQQ.LSP.......AVGDKQPTI.LKWRILSATNDLDRVSAVALPK..........L........PISLTNTDL...KVASDTQFY......PGLGLALAFHDGSVHIVHRL.SLQTMAIFYSSAAPRPIDEPALKRP...RTTG.PAV.HFKAMQL..SWTSLALVGIDNHGRLSMLRISPSM...GHSLDVGLALRHLLfLLEYCMVTGYdWWDILL
  491-  647 (178.74/89.33)	LVE..KLHEEYTRQKAELQQvLST....................RILAMKASLCKLSPCTVTRvcdyhaklflI........AISSTLKSLlrpHVLNTPDKS......PGDRLT....EICAKITD.V.DIDKVMINLKT......EEFVL..D...MNTL.QAL.Q.QLLQWvgDFVLYLLASLPNQG..SPLRPGHSFlrdGTSL..GM.LRELM..................
  649-  826 (211.30/107.39)	VIRIWGL..............LKPsclpvytATSDTQDSMsLLFRLLT..............K..........LwiccrdegPTS..EPDE...ALVDECCLLpsqlliPSLDW.LPVSDG...LVSRLqPKQPLRLHFGKAPALPGSSTGLQLDgliRAPGqPKMdHLRRLHL.gAYPTEACKACTRCGCVTMLK.SPN.....KTTAVKQWEQR...WIKNCLCGGL.WWRMPL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28442 with Med16 domain of Kingdom Metazoa
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