<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28439

Description Mediator of RNA polymerase II transcription subunit 23
SequenceMVQMETQLQSIFEEVVKTEIIEEAFPGMFMDTPEDEKTKLISCLGAFRQFWSGLSQESHEQCIQWIVKFIHGQHSPKRISFLYDCLAMAVETGLLPPRMVCETLINSDTLEWERTQLWALTFKLVRKIIGGVDYKGVRDLLKAILEKILTIPNTVSSAVVQQLLAAREVSRCASFRSIPTASKGRCSLLPVVNNSGAICNSWKLDPATLRFPLKGLLPYDKHKQRCPVLEDQLVDLVVYAMERSETEEKFDDGGTSQLLWQHLSSQLIFFVLFQFASFPHMVLSLHQKLAGRGLIKGRDHLMWVLLQFISGSIQKNALADFLPVMKLFDLLYPEKEYIPVPDINKPQSTHAFAMTCIWIHLNRKAQNDNSTLQIPIPHSLKLHHEFLQQSLRNKSLQMNDYKIALLCNAYSTNSECFTLPMGALVETIYGNGIMRIPLPGTSCLASGSITPLPMNLLDSLTVHAKMSLIHSIATRVIKLAHAKSSVALAPALVETYSRLLVYMEIESLGIKGFISQLLPTVFKSHAWGILHTLLEMFSYRMHHIQPHYRVQLLSHLHTLAAVAQTNQNQLHLCVESTALRLITALGSSEVQPQFTRFLSDPKTVLSAESEELNRALILTLARATHVTDFFTGSDSIQGTWCKDILQTIMSFTPHNWASHTLSCFPGPLQAFFKQNNVPQESRFNLKKNVEEEYRKWKSMTNENDIITHFSIQGSPPLFLCLLWKMLLETDHINQIGYRVLERIGARALVAHVRTFADFLVYEFSTSAGGQQLNKCIEILNDMVWKYNIVTLDRLILCLAMRSHEGNEAQVCYFIIQLLLLKPNDFRNRVSDFVKENSPEHWLQNDWHTKHMNYHKKYPEKLYFEGLAEQVDPPVQIQSPYLPIYFGNVCLRFLPVFDIVIHRFLELLPVSKSLETLLDHLGGLYKFHDRPVTYLYNTLHYYERYLRNRDHLKRKLVHAIIGSLKDNRPQGWCLSDTYLKNVMNPREDNPWVPDDSYYCKLIGRLVDNILQIVTFCTLSNNGSGFSQCYLIGTLSF
Length1035
PositionTail
OrganismHeterocephalus glaber (Naked mole rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Heterocephalus.
Aromaticity0.10
Grand average of hydropathy-0.054
Instability index41.23
Isoelectric point7.92
Molecular weight118563.21
Publications
PubMed=21993625

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28439
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     101.12|      32|     121|     586|     629|       1
---------------------------------------------------------------------------
  544-  584 (28.35/ 8.48)	....IQPHYrVQLLSHLHTLaavaqtnqnqlhLCVESTALR..LITA
  586-  619 (48.17/51.72)	GSSEVQPQF.TRFLSDPKTV............LSAESEELNraLILT
  632-  650 (24.60/ 8.04)	GSDSIQGTW.CKDIL..QTI............MS.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.14|      10|      31|     268|     277|       2
---------------------------------------------------------------------------
  268-  277 (18.69/ 9.86)	IFFVLFQFAS
  301-  310 (19.45/10.55)	LMWVLLQFIS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.29|      16|      95|     322|     341|       3
---------------------------------------------------------------------------
  322-  337 (28.54/12.72)	LPVMKLFDLLYPEKEY
  419-  434 (26.75/11.09)	LPMGALVETIYGNGIM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.64|      14|      16|     975|     988|       6
---------------------------------------------------------------------------
  975-  988 (25.32/17.71)	DTYLKNVMNPREDN
  994- 1007 (25.31/17.70)	DSYYCKLIGRLVDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.15|      28|     648|      32|      59|       7
---------------------------------------------------------------------------
   32-   59 (51.54/29.29)	TPEDEKTKLISCL.GAFRQFW..SGLSQESH
  652-  682 (45.61/25.11)	TPHNWASHTLSCFpGPLQAFFkqNNVPQESR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     174.64|      58|     326|     140|     202|      10
---------------------------------------------------------------------------
  140-  202 (87.05/82.53)	LLKAILEKILTIPNTVSSAVVQQLLaAREVSRCASFRSIPTAS.KGRCS.LLPVVNNSGAicnsW
  468-  527 (87.60/66.08)	LIHSIATRVIKLAHAKSSVALAPAL.VETYSRLLVYMEIESLGiKGFISqLLPTVFKSHA....W
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     115.99|      33|      74|     703|     737|      12
---------------------------------------------------------------------------
  703-  737 (55.26/39.74)	NDIITHFSIQGSPPLFLCLlwKMLLETDHINQIGY
  780-  812 (60.73/36.43)	NDMVWKYNIVTLDRLILCL..AMRSHEGNEAQVCY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28439 with Med23 domain of Kingdom Metazoa
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