<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28437

Description Mediator of RNA polymerase II transcription subunit 17
SequenceMSGVRAVRISIESACEKQVQEVGLDGTETYLQPLSMSQNLARLAQRIDFSQGSGSEEEEAAGAEGDSQDWAGAGSSADQDDEEGLVKFQPSLWPWDSVRNNLRSALTEMCVLYDVLSIVRDKKFMTLDPVSQDALPPKQVSIQKQAPDIGDLGTVNLFKRPLPKSKPGSPHWQTKLEAAQNVLLCKEIFAQLSREAVQIKSQIPHIVVKNQIISQPFPTSAPFGHKRMRLSGPQAFDKNEINSLQSSEGLLEKIIKQAKHIFLRNRTAATIDSLASRIEDPQIQAHWSNINDVYESSVKVLITSQGYEQICKSIQLQLNIGVEQIRVVHRDGRVITLSHQEQELQDFLLSQMSQHQVHAVQQLAKVMGWQVLSFSNHVGLGPIESIGNASAITVASPSGDYAISVRNGPESGSKIMVQFPRNQCKDLPKNDVLQDSKWNHLRGPFKEVQWNKMEGRNFVYKMELLMSALSPCLL
Length474
PositionHead
OrganismHeterocephalus glaber (Naked mole rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Heterocephalus.
Aromaticity0.06
Grand average of hydropathy-0.373
Instability index59.10
Isoelectric point6.29
Molecular weight52753.37
Publications
PubMed=21993625

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28437
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.55|      23|     125|      16|      38|       1
---------------------------------------------------------------------------
   16-   38 (39.91/27.15)	EKQVQEVGLDGT.ETYLQPLSMSQ
  143-  166 (36.64/24.36)	QKQAPDIGDLGTvNLFKRPLPKSK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     180.30|      55|     333|      50|     108|       3
---------------------------------------------------------------------------
   50-  108 (92.49/64.66)	SQGSGSeeeeAAGAEGDSQDWAGAGSSADQDDEEGLVKF...QPSLWP.....WDSVRNNLRSALTE
  385-  447 (87.81/53.18)	SIGNAS....AITVASPSGDYAISVRNGPESGSKIMVQFprnQCKDLPkndvlQDSKWNHLRGPFKE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.41|      22|     113|     171|     194|       4
---------------------------------------------------------------------------
  171-  192 (40.23/26.54)	HW...QTKLEAAQNVL........LCKEIFAQL
  286-  318 (28.18/11.44)	HWsniNDVYESSVKVLitsqgyeqICKSIQLQL
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28437 with Med17 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QGSGSEEEEAAGAEGDSQDWAGAGSSADQDDEE
51
83










Molecular Recognition Features






MoRF SequenceStartStop




1) LARLAQRIDF
40
49