<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28436

Description Mediator of RNA polymerase II transcription subunit 26 (Fragment)
SequenceIRNMVAVLEVISSLERYPITKEALEETRLGKLVNDVRKKTKNEELAKRAKKLLRSWQKLIEPVQQNEVALRGANGGAHNCRPEAGASVSKGVPDLKHRNDLQRLPGPRLDRLGSRKRRGDQRDLGHPGPPPKVSKACHDLLGPNSSPLPTNGISGSPESFSSPLDGSGLMGSEGSRLEAVENDQLSGKVPVNAVRPHPSSPGLGQPPGPCLQAKVEETSGPPHPRAPSRCSFSPRNSRHEGSFARQRSPYTPKGSVPSPSPRPLVLEATQVPSPPPLDQPPRAGFSPDSSKADSDAASSGGSDSRKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPMRADSPVHTEQPPRTELDKQEAKASLQSPFEQTNWKELSRNEIIQSYLSRQSSLLSSSGAQTPGAHPFMAEYLRQEESTRRGARQPHVLVPHAPPADLPGLSREVTQGDLDRLQADQWPGVNGCQDTQGNWYDWTQCISLDPHGDDGRLNVLPYVCLD
Length513
PositionUnknown
OrganismHeterocephalus glaber (Naked mole rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Heterocephalus.
Aromaticity0.04
Grand average of hydropathy-0.889
Instability index59.43
Isoelectric point9.37
Molecular weight56154.34
Publications
PubMed=21993625

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28436
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     142.66|      23|      24|     287|     309|       1
---------------------------------------------------------------------------
  131-  154 (27.47/ 8.46)	PK..VS.KACHDLLGPNSSPlPTNGIS
  157-  179 (26.11/ 7.67)	PE..SF.SSPLDGSGLMGSE.GSRLEA
  182-  206 (28.50/ 9.04)	NDqlSG.KVPVNAVRPHPSS.PGLGQP
  207-  229 (27.79/ 8.64)	PG..PClQAKVE.ETSGPPH.PRAPSR
  287-  309 (32.79/11.51)	PD..SS.KADSDAASSGGSD.SRKKKR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      99.75|      23|      84|     259|     282|       2
---------------------------------------------------------------------------
  233-  258 (32.16/ 9.41)	SPRNSRHEGSfaRQRSPyTPKGSVPS
  260-  282 (43.63/20.73)	SPRPLVLEAT..QVPSP.PPLDQPPR
  354-  369 (23.96/ 6.84)	.......EPM..RADSP.VHTEQPPR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.66|      12|      21|      96|     107|       3
---------------------------------------------------------------------------
   96-  107 (24.77/10.40)	KHRNDLQRL..PGP
  116-  129 (19.88/ 7.15)	KRRGDQRDLghPGP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.15|      15|      22|     402|     418|       5
---------------------------------------------------------------------------
  402-  418 (21.71/15.49)	YLSRQSSllSSSGAQTP
  427-  441 (27.44/13.91)	YLRQEES..TRRGARQP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28436 with Med26 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QQNEVALRGANGGAHNCRPEAGASVSKGVPDLKHRNDLQRLPGPRLDRLGSRKRRGDQRDLGHPGPPPKVSKACHDLLGPNSSPLPTNGISGSPESFSSPLDGSGLMGSEGSRLEAVENDQLSGKVPVNAVRPHPSSPGLGQPPGPCLQAKVEETSGPPHPRAPSRCSFSPRNSRHEGSFARQRSPYTPKGSVPSPSPRPLVLEATQVPSPPPLDQPPRAGFSPDSSKADSDAASSGGSDSRKKKRYRPRDYTVNLDGQVAEAGVKPVRLKERKLTFDPMTRQIKPLTQKEPMRADSPVHTEQPPRTELDKQEAKASLQSPFEQTNW
2) RQSSLLSSSGAQTPGAHPFMAEYLRQEESTRRGARQPHVLVPHAPPADLPGLSREVTQGDLDRLQADQWP
64
405
390
474










Molecular Recognition Features






MoRF SequenceStartStop




1) RKKKRYRPRDYTVNLDGQVA
2) RLKERKL
305
332
324
338