<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28435

Description Mediator of RNA polymerase II transcription subunit 12-like protein (Fragment)
SequenceFSVFQDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKILNKKSTTETGAGDEGPKARKNKQESFPTLETVFTKLQLLSYFDQHQVTSQISNNVLEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVAVLRQYHSCLILNPDQTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSINYSMLGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDSLATFIAILIARQCFSLEDVVQHVALPSLLAAACGDADAEPGARMTCRLLLHLFRAPQACFLPQAGGKPFPGIRSSCDRHLLAAAHNSIEVGAVFAVLKAIMMLGDAKIGSNNVSSLKNDDFAMRSLRRDGNADDIWTTSQNAKSCGKIISIETANLREYARYVLRTICQQEWVGEHCLKEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGIKECTDGDNLQRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGSGSVTEMNNLLDNIAKATIEVFQQSADLNNNSSNSGMSLFNPNGIGSADTSSTRQNGIKTFLSSSERRGVWLVAPLIARLPTSVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLQNQVNQILSNWREERYQDDIKARQMMHEALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLASDLSNASPGGSEENKRAYMNLVKKLKKELGDKRSESIDKVRQLLPLPKQTCDVITCEPMGSLIDTKGNKIAGFDSIDKKQARENGLQVSTKQKVSPWDLFEGQKNPAPLSWAWFGTVRVDRKVIKYEEQHHLLLYHTHPMPKPRSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKPSSRVDDYPQSNIYRVPPNYSPISSQMMHHPQATLWGYNLMGQPQQPGFFLQNQSLTPGGSRLDPAGTFVPTNTKQALSNMLQRRSGAMMQPPSLHAITSQQQLIQMKLLQQQQQQRFLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPLQQTAQQQAGGVVLSPSYNSRVYPAAHSSPALMERLRQIQQQPSGYVQQQASPYLQPLTSSQRLNHQALQQSPLVAGGIDAVLPSAHPNLVVSLPQDPMRPRQPQPRQQQRLLQIQQPPQPPQPQQPPQPQQSSQPQNQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVISHSKEWLPMDILHTSESGGEDTQFYVCTEK
Length1446
PositionKinase
OrganismHeterocephalus glaber (Naked mole rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Heterocephalus.
Aromaticity0.06
Grand average of hydropathy-0.451
Instability index61.23
Isoelectric point7.84
Molecular weight161491.96
Publications
PubMed=21993625

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28435
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     223.56|      27|      28|    1339|    1365|       1
---------------------------------------------------------------------------
 1191- 1218 (34.52/12.99)	RQA...............Q.TRPfQQG.QPGDQAAL.FAAQARPSP
 1221- 1247 (35.65/13.68)	PQY...............PgLQQ.AQT.MP.QGYTM.YGTQMPLQQ
 1250- 1289 (27.11/ 8.44)	QQQaggvvlspsynsrvyP...A.AHS.SPALMERL.RQIQQQPSG
 1294- 1319 (27.39/ 8.62)	QAS...............PyLQP.LTS.SQRLNHQA.L..QQSPLV
 1339- 1365 (56.35/26.39)	PQD...............P.MRP.RQP.QPRQQQRL.LQIQQPPQP
 1368- 1395 (42.53/17.90)	PQQ...............P.PQP.QQSsQP.QNQTLgLQAMQPQQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     127.84|      42|     140|     588|     646|       2
---------------------------------------------------------------------------
  528-  572 (70.62/31.08)	NL.REYARYVLRTICQ....QEWVG.....EHCLKEPERLCTDKeliLDPVLSNM
  595-  646 (57.23/56.56)	NLqRQHIKRILQNLEQwtlrQSWLElqlmiKQCLKDPGSGSVTE...MNNLLDNI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      52.17|      16|      27|     154|     170|       3
---------------------------------------------------------------------------
  154-  170 (22.97/16.08)	LLLKSSSLAGSYtTGLC
  184-  199 (29.21/16.20)	LILNPDQTAQVF.EGLC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      87.35|      24|      27|     762|     785|       4
---------------------------------------------------------------------------
  740-  760 (17.95/ 6.54)	.....KE...RDR..QKQKSMSLLSQQpfLS
  762-  785 (38.58/23.30)	VLTCLKG...QDE..QREGLLTSLQNQ..VN
  787-  815 (30.82/17.00)	ILSNWREeryQDDikARQMMHEALQLR..LN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.49|      23|      26|     822|     846|       5
---------------------------------------------------------------------------
  822-  846 (33.71/27.48)	DTVQRSTQWTTdwALLLLQIITSGT
  848-  870 (39.78/23.96)	DMHTNNELFTT..VLDMLGVLINGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.09|      26|      26|    1131|    1156|       6
---------------------------------------------------------------------------
 1131- 1156 (44.01/24.04)	GSRLDPAGTFVPTNTKQALS.NMLQRR
 1158- 1184 (40.07/21.23)	GAMMQPPSLHAITSQQQLIQmKLLQQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.62|      14|      27|     413|     428|       7
---------------------------------------------------------------------------
  413-  428 (23.57/17.72)	PGARMTCRllLHLFRA
  443-  456 (27.04/14.31)	PGIRSSCD..RHLLAA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.69|      18|      27|     287|     305|       8
---------------------------------------------------------------------------
  287-  305 (27.81/24.99)	GKIlSD..NAANRYSFVCNTL
  316-  335 (27.88/19.22)	GRI.NDiaNFSSELTACCTVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.83|      12|      30|      22|      33|       9
---------------------------------------------------------------------------
   22-   33 (21.85/15.05)	GVGKERDEARHQ
   54-   65 (21.99/15.20)	GAGDEGPKARKN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.88|      22|      30|     209|     233|      10
---------------------------------------------------------------------------
  209-  233 (33.97/26.38)	SECSSPERCIlaYlYDLYVSCSHLR
  242-  263 (36.91/18.90)	SACSKVKQTI..Y.NNVMPANSNLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.28|      14|      24|    1072|    1085|      11
---------------------------------------------------------------------------
 1072- 1085 (26.87/14.33)	P.....SSRVDDYPQSNIY
 1089- 1107 (23.41/11.53)	PnyspiSSQMMHHPQATLW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.68|      14|      24|     932|     946|      12
---------------------------------------------------------------------------
  932-  946 (19.75/17.54)	GSLIDTKgNKIAGFD
  957-  970 (25.93/17.12)	GLQVSTK.QKVSPWD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.42|      19|      30|     664|     683|      13
---------------------------------------------------------------------------
  664-  683 (29.55/25.35)	SSNSGMSLFNPnGIGSADTS
  697-  715 (33.87/23.46)	SERRGVWLVAP.LIARLPTS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.69|      21|      26|     467|     488|      17
---------------------------------------------------------------------------
  467-  488 (30.83/25.05)	FAvLKAIMMLGDAK...IGSNNVSS
  494-  517 (30.86/19.84)	FA.MRSLRRDGNADdiwTTSQNAKS
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28435 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) QPGFFLQNQSLTPGGSRLDPAGTFVPTNTKQALSNMLQRRSGAMMQPPSLHA
2) QQRFLRQAQTRPFQQGQPGDQAALFAAQARPSPQLPQYPGLQQAQTMPQGYTMYGTQMPL
3) RSYYLEPLPLPPEEEEEEPTSPVSQEPERKSAELSDQGKTTTDEEKKTKGRKRKTKPSSRVDDYPQSNIYRVPPNYSPISSQMMH
4) SAHPNLVVSLPQDPMRPRQPQPRQQQRLLQIQQPPQPPQPQQPPQPQQSSQPQNQTLGLQAMQPQQPLFPRQGLQQTQQQQQTAALVISHSKEWLPMDILHTSESGGEDTQFYVCTE
5) YPAAHSSPALMERLRQIQQQPSGYVQQQASPYLQPLTSSQRLNHQALQQSPLVAGGIDAV
1117
1186
1016
1329
1267
1168
1245
1100
1445
1326










Molecular Recognition Features






MoRF SequenceStartStop




1) YYLEPL
1018
1023