<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28434

Description Mediator of RNA polymerase II transcription subunit 12-like protein
SequenceMGGILSNHKEEELKVCLDHGSADFPGPAGSLRLRAAVSGCSRQVAQCLGAHAPKRARSAGWLDAVGPAGSLPLAPFTRPEQVRFLAQAAGTGTSGDVEAEAAALGLQGVPRPPPPQPPQVRPPAARSAAAKPRRGGSERSALEANSSAVRRAGHAQCGPAPRPSANSEARAPGPWGRGRRRCSAPPDSGKLRGIPGARSGETAISPIKSSPIPPSLPERWKLRPPECPRCRRPLPASPGPTALTWGQVGPAGIAGDPLATILSGCHSLRSTGALALQVPGRFPVIGPCTEPPGASPDPSLPKSSCLLSSPSACFIFLSVVSVNPRKLFEKCWNAVHPTIGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLAILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQPTDPNLEWTQISTRYLREQLAKISDFYHMASSTSDGPIPVPPDVEQAMKQWEYNEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLKLLLPLMLQYSDEFVQSAYLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPMQLAFSDFLSCAQHGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQMAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAEAQSKTPLIKYGEKALKLKVAPNDEAVVMLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEAERCGESEVLDEKESISSASLAGSGLPIFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTGPRSPAGENADEHYSKDHNIKMEV
Length900
PositionKinase
OrganismHeterocephalus glaber (Naked mole rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Heterocephalus.
Aromaticity0.07
Grand average of hydropathy-0.280
Instability index57.32
Isoelectric point8.94
Molecular weight97605.94
Publications
PubMed=21993625

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28434
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     284.26|      38|      38|      64|     101|       1
---------------------------------------------------------------------------
   26-   58 (43.94/14.76)	..GPAGSLR....LRAAVSGCS.RQVA..QCLGAHAPK..RARS
   64-  101 (65.92/25.88)	AVGPAGSLP....LAPFTRPEQVRFLA..QAAGTGTSGDVEAEA
  103-  141 (55.73/20.73)	ALGLQG.VP....RPPPPQPPQVRPPAarSAAAKPRRGGSERSA
  148-  169 (34.14/ 9.80)	AVRRAGHAQ....CGPAPRP..................SANSEA
  171-  202 (47.01/16.31)	APGPWGRGR....RRCSAPPDSGK.LR..GIPG.ARSG..ET..
  211-  242 (37.52/11.51)	PIPP..SLPerwkLRPPECPRCRRPL....PASPGPTA......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     135.87|      38|      39|     431|     469|       2
---------------------------------------------------------------------------
  431-  464 (54.54/31.90)	...............KMTCAYY..SAISEAKIKKRQPTDPNLEWTQISTRY
  466-  502 (52.67/31.94)	REQL..........aKISDFYHmaSSTSDGPI....PVPPDVEQAMKQWEY
  503-  539 (28.67/10.34)	NEKLafhmfqegmleKH..EYL..TWILDV.LEKIRPMDDDL.........
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      73.71|      22|      38|     250|     273|       3
---------------------------------------------------------------------------
  250-  273 (31.41/22.00)	PAGIAGDPlATILSGChSLRSTGA
  291-  312 (42.30/20.73)	PPGASPDP.SLPKSSC.LLSSPSA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      71.69|      21|     293|     546|     568|       8
---------------------------------------------------------------------------
  546-  568 (30.39/31.37)	LMLQYSdEFVQSAYLSRRlAYFC
  842-  862 (41.29/30.06)	LVLLFC.EFIRHDVFSHD.AYMC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28434 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) PAGSLPLAPFTRPEQVRFLAQAAGTGTSGDVEAEAAALGLQGVPRPPPPQPPQVRPPAARSAAAKPRRGGSERSALEANSSAVRRAGHAQCGPAPRPSANSEARAPGPWGRGRRRCSAPPDSGKLRGIPGARSGETAISPIKSSPIPPSLPERWKLRP
67
224










Molecular Recognition Features






MoRF SequenceStartStop




NANANA