Description | Mediator of RNA polymerase II transcription subunit 11 |
Sequence | MATYSLANERLRALEDIEREIGAILQNAGTVILELSKEKTNERLLDRQAAAFTASVQHVEAELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKLSDVARTCEQMLES |
Length | 117 |
Position | Head |
Organism | Heterocephalus glaber (Naked mole rat) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Heterocephalus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.417 |
Instability index | 32.98 |
Isoelectric point | 5.71 |
Molecular weight | 13101.67 |
Publications | PubMed=21993625 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364147 |
GO - Cellular Component | mediator complex GO:0016592 IEA:Ensembl |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP28430 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 72.53| 24| 31| 8| 36| 1 --------------------------------------------------------------------------- 8- 36 (33.02/35.01) NERLraledIEREIGAILQNAGTVILELS 41- 64 (39.51/28.01) NERL.....LDRQAAAFTASVQHVEAELS --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) ERLLDRQA 2) VEAELSAQIRYLTQVATGQPHEGSSYSSRKDCQMALKRVDYARLKLSDVARTC | 42 59 | 49 111 |
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