<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28429

Description Mediator of RNA polymerase II transcription subunit 12
SequenceMDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLPDTGRRRPQVNQKDHFWLVTTRSQIAISTWFTDLAGTKPLTQLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSENKVKKRQVVDPFMEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCSSTIGPLPHDVEVAIRQWDYNEKLAMFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVISTQSTSTLPNTPAPQPSTSNTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPADDAERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEGKLPPKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVRFGVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGTSSPDKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVTGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILQNLDQWTMRQSSLELQLMIKQTPNNEMNSLLENIAKATIEVFQQSAETGSSSGSTANNIPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLTSLYNQVHQIVNNWRDDQYLDDYKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAVLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKELGEHQSDSLEKVRQLLPLPKPTRDVITCEPQGSLIDTKGNKIAGFDSIFKKEAFRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPTLLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKTEDYGMGPGRSGPYGVTVPPDLLHHANPSSISHLSYRQGSIGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMTGVMGLEPSSYKTSVYRQQQPAVPQGQRLRQQLQAKIQSQGILGQSSVHQMTPSSSYGLQTSQGYTPYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPIMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQILRFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY
Length2051
PositionKinase
OrganismHeterocephalus glaber (Naked mole rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Heterocephalus.
Aromaticity0.07
Grand average of hydropathy-0.408
Instability index52.48
Isoelectric point6.48
Molecular weight228003.45
Publications
PubMed=21993625

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
beta-catenin binding	GO:0008013	IEA:InterPro
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28429
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.71|      18|      18|    2003|    2020|       1
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 2003- 2020 (32.76/16.37)	QQQQQILRFQRQGLQQTQ
 2023- 2040 (28.96/13.64)	QQTAALVRQLQQQLSNTQ
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     815.11|     218|     231|     318|     546|       2
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  138-  349 (247.32/159.75)	............................MS.........E.NKVKKRQVVDPFMEWTQIItKYLWEQLQKMAE..YYRPGPAGSGgcsSTIGPLPHDVEV....AIRQWDYNEKLamfmfqDGM..LDRHEF.LTWVLECFEkIRPGEDELLKLLLPLLL......RYSGE...FVQSAYLSRR.LAYFCTRRLAlQL..DGVSSHSShvISTQSTSTlPNTPAPQPSTSNTP...STPfsdLLMCPQ...HRPLVFGLscilqtILLCCPsaLVWH
  350-  575 (349.22/214.64)	YSLT.DSR..IKTGSPldhLPIAPSNLPMP.........EGNSAFTQQVRAKLREIEQQI.KERGQAVEVRWS..FDKCQEATAG...FTIGRVLHTLEVLDSHSFERSDFSNSL......DSL..CNRIFG.LGPSKDGHE.ISSDDDAVVSLLCEWAV....SCKRSGRHRAMVVAKLLEKR.QAEIEAERCG.ES..EAADEKGS..VASGSLSA.PSAPIFQDVLLQFL...DTQ.apMLTDPRsesERVEFFNL......VLLFCE..LIRH
  583-  782 (218.57/124.73)	YTCTlISRgdLAFGAP...GPRPPSPFDDPaddaerkeaEGSSS.........SKLEDPG.LSESMDIDPSSSvlFEDMEK..PD...FSLFSPTMPCEGKGSPSPEKPDVEKE.......GKLppKEKIEGtLG........ILYDQPRHVQYATHFPIpqeeSCSHECNQRLVVLFGVGKQRdDARHAIKKIT.KDilKVLNRKGT..AETDQL.A.PIVPL.NPGDLTFLggeDGQ......................................
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     518.34|     139|     148|    1631|    1777|       3
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 1576- 1622 (38.31/10.87)	.....SSIS.....QGSM....E.ENKR.A.YMNLVKK....LQKEL..GEHQSDSLEKVRQLLPLPKPT................................................................................................................
 1631- 1764 (207.43/108.71)	..............QGSL.IDTK.GNKI.AGFDSIFKKeAFRVDRRVarGEEQQRLLLYHTHLRPRPRAYYLEP..LPLPPEDEEPPA.PTL.............LEPEKKAPEPPKTDKPGAAPpsTEERKKKSTKGKK.RSQPATKTEDYG.........MGP....G.RSGPYGVTVPP
 1768- 1890 (127.17/59.28)	HHANPSSISHlsyrQGSIgLYTQ.NQPLpAG........GPRVD..........................PYRP..VRLPMQ.KLPTR.PTYpgvlpttmtgvmgLEPSSYKTSVYRQQQP.AVP...........QGQRlRQQLQAKIQSQGilgqssvhqMTP.......SSSYGLQTS.
 1891- 1998 (145.44/63.51)	QGYTP.YVSH.............vG...............................LQQHTG....PAGTMVPPsySSQPYQSTHPSTnPTL.............VDPTRHLQQRPSGYVHQQAP..TYGHGLTSTQ.RF.SHQTLQQTPIMG........tMTPlsaqGvQAGVRSTSILP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.98|      15|      15|     822|     836|       4
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  822-  836 (26.85/15.25)	LEQITSFALG.MSYHL
  838-  853 (23.14/12.23)	LVQHVQFIFDlMEYSL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.14|      13|      16|     996|    1008|       5
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  996- 1008 (25.11/17.00)	ENPAA.HTFTYTGL
 1014- 1027 (21.03/12.87)	ENPANrYSFVCNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     142.78|      33|     148|     891|     927|       6
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  891-  927 (54.42/44.26)	LClcivAVLRH.YHACLILNQDQMAQVFEGLCGVVKHG
  942-  970 (34.71/17.50)	......AYLYDlYTSCSHL.KSKFGELFSDFCSKVK..
 1046- 1075 (53.65/33.31)	LC....AELTG.Y..CKSLSAEWLG.VLKALCCSSNNG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.92|      24|      61|    1354|    1377|       7
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 1354- 1377 (38.04/25.76)	SLLENIAKATIEVFQQSAETGSSS
 1415- 1438 (39.88/27.41)	SVQGHVLKAAGEELEKGQHLGSSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.80|      21|      23|    1529|    1549|       8
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 1529- 1549 (36.29/26.89)	QQTTEWAVL.LLEIIISGTV..DM
 1552- 1575 (26.50/17.49)	NNELFTTVLdMLSVLINGTLaaDM
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.03|      14|      16|    1305|    1319|       9
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 1305- 1319 (22.26/17.01)	HRLLDNEDgENPQRQ
 1322- 1335 (25.76/14.62)	KRILQNLD.QWTMRQ
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28429 with Med12 domain of Kingdom Metazoa
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