Description | Mediator of RNA polymerase II transcription subunit 4 |
Sequence | MPCASTGCWSAGRMAASSSGEKEKERLGGSSASAGSNSTREGKIHHEMQVLEKEVEKRDSDIQQLQKQLKEAEQILATTVYQAKEKLKSIEKARKGAISSEEIIKYAHRISASNAVCAPLTWVPGDPRRLYPTDLEMRSGLLGQMNNPSTNGVNGHLPGDALAAAGRLPDVLAPQYPWQSNDMSMNMLPPNHSNDFLLEPPGHNKENEDDVEVMSTDSSSSSSDSD |
Length | 226 |
Position | Middle |
Organism | Heterocephalus glaber (Naked mole rat) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Heterocephalus. |
Aromaticity | 0.04 |
Grand average of hydropathy | -0.742 |
Instability index | 50.78 |
Isoelectric point | 5.32 |
Molecular weight | 24507.98 |
Publications | PubMed=21993625 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364141 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP28428 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 68.82| 24| 33| 53| 77| 1 --------------------------------------------------------------------------- 53- 77 (34.27/29.20) KEVEK.RDSDIQQlQKQLKEAEQILA 88- 112 (34.54/24.20) KSIEKaRKGAISS.EEIIKYAHRISA --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) GEKEKERLGG 2) LEPPGHNKENEDDVEVMSTDS 3) PRRLYP | 20 198 127 | 29 218 132 |
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