<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28427

Description Mediator of RNA polymerase II transcription subunit 24
SequenceMKVVNLKQAILQAWKERWSDYQWAINMKKFFPKGATWDILNLAEALLEQAMIGPSPNPLILSYLKYAISSQMVSYSSVLTAISKFDDFSRDLCVQALLDIMDMFCDRLREPKALGNVREGRVSASGAWTDSPPLLQLSRQSRGVHRAVPGPPQRPPLAGAGPSFERLQEAPEATSPGTSEKQLAMCLQRLEKTLSSSKNRALLHIAKLEEASSWTAIEQCLLKLGETLANLSSPQLRSQAEQCGVLIRSIPTMLSVHSERLHETGFPTVHAVVLLEGTMNLTGETQPLVEQLMMVKRMQHIPTPLFVLEIWKACFVGLIESPEGTEELKWTAFTYLKIPQVLVKLKKYSHGDRDFTEDVNCAFEFFFLKLTPLLDKADQRCNCDCTNFLLQECNKQGLLSEASFASLMAKCKSDREQAPQLKSSENANIQPNPGLILRAEPTVTNILKTMDADHSKSPEGLLGVLGHMLSGKSLDLLLAAAAATGKLKSFARKFINLNEFTTHGPGESTKTASVRALLFDISFLMLCHVAQTYGSEVILSEASSGAEVPFFETWMQTCMPEEGKILNPDHPCFRPDSTKVEQMKWHEACLSISAAILEILNAWENGVLAFESIQKITDNIKGKVCSLAVCAVAWLVAHVRMLGLDEREKSLQMIRQLAGPLYSENTLQFYNERVVIMNSILEHMCADVLQQTATQIKFPSTGVDTMPYWNLLPPKRPIKEVLTGVFAEVLEKGWVDSRSVHILDTLLHMGGVYWFCSNLLKELLKETRKEHTLRAVELLYSIFCLDMQQVTLVLLGHILPGLLTDSSKWHSLMDPPGTALAKLAVWCALSAYSSHKGQASSRQKKRHREDIEDYTSLFPLDDTQPSKLMRLLSSNEDDANILSSPTDRSMSSSLSASQLHTVNMRDPLNRVLVLLPQPPESWESRRAPPRLPSFAWSPAWPHLAPPEPLLPPRSQLVPAXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXGSRGSILQFMPFTTVSELVKVSSMSSPKVVLAITDLSLPLGRQVAAKAIAAL
Length1042
PositionTail
OrganismHeterocephalus glaber (Naked mole rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Heterocephalus.
Aromaticity0.07
Grand average of hydropathy-0.085
Instability index51.91
Isoelectric point6.79
Molecular weight112366.98
Publications
PubMed=21993625

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28427
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     116.38|      36|      38|     738|     773|       1
---------------------------------------------------------------------------
  738-  773 (64.10/41.61)	RSVHILDTL..LHMGGV.YWFCSNLLKELLKETRKEHTL
  774-  812 (52.29/32.60)	RAVELLYSIfcLDMQQVtLVLLGHILPGLLTDSSKWHSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.32|      14|      29|     554|     567|       2
---------------------------------------------------------------------------
  554-  567 (28.26/21.62)	WMQTCMPEEGKILN
  585-  598 (25.06/18.16)	WHEACLSISAAILE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      77.20|      16|     587|     136|     155|       3
---------------------------------------------------------------------------
  132-  147 (25.79/ 6.37)	PPLLQLSRQSRGVHRA
  152-  166 (20.77/11.88)	PQRPPLAGAGPSFER.
  928-  943 (30.64/ 9.80)	PPRLPSFAWSPAWPHL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      78.90|      23|      31|     333|     355|       6
---------------------------------------------------------------------------
  333-  355 (40.57/29.54)	FTYLKIPQVLVKLKKYSHGD.RDF
  365-  388 (38.33/27.47)	FFFLKLTPLLDKADQRCNCDcTNF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28427 with Med24 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LPPRSQLVPAXXXXXXXXXXXXXXXXXXXXXXXXXXXX
2) RQSRGVHRAVPGPPQRPPLAGAGPSFERLQEAPEATSPGTSEKQ
950
139
987
182










Molecular Recognition Features






MoRF SequenceStartStop




1) DQTKKEAEPTPETIKS
2) KNVQQTLSTKGPPEKRIRLQ
3) RDDYGLL
4) VDALLVDLRQKFPPKFVQ
248
270
8
220
263
289
14
237