<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28413

Description Mediator of RNA polymerase II transcription subunit 25
SequenceMPCTSAPGARARLAHFRSFGGGLWRRWRLPLRAGGLVADVVFVIEGTANLGPYFEELRKYYLLPAIEYFNGGPPAETDFGGDYGGTQYSLVVFNTVDCAPESYVQCHAPTSSAYEFVTWLDGIKFMGGGGESCSLIAEGLSTALQLFDDFKKMREQIGQTHRVCLLICNSPPYLLPAVESTTYSGYTTESLVQEIGERGIHFSIVSPRKLPALRLLFEKAAPPAMLETLQPPADVSQDPRHMVLVRGLVLPVGGGSAPGPLQPKQQVPLPPAPPSGATLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAPSGVGPPFSQATAPALPPGPSGATKAPPASQPNLVSTVAPGPGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALGGQQSVSNKLLAWSGVLEWQEKPKPASVDANTKLTRSLPCQVYVNHGENLKTEQWPQKLIMQLIPQQLLTTLGPLFRNSRMVQFHFTNKDLESLKGLYRIMGNGFAGCVHFPHTAPCEVRVLMLLYSSKKKIFMGLIPYDQSGFVNGIRQVITNHKQVQQQKLEQQRGMGQQAPPGLGPILEDQARPSQNLQLQLRPPQPQPQGTVGASGATGQPQPPGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPGQMLLSGGPRGPVPQPGLQPSVMEDDILMDLI
Length768
PositionUnknown
OrganismHeterocephalus glaber (Naked mole rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Heterocephalus.
Aromaticity0.06
Grand average of hydropathy-0.257
Instability index62.20
Isoelectric point9.07
Molecular weight80971.05
Publications
PubMed=21993625

Function

Annotated function 
GO - Cellular Component
nucleus	GO:0005634	IEA:UniProtKB-SubCell

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28413
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     524.55|      64|      65|     589|     652|       1
---------------------------------------------------------------------------
  215-  274 (75.31/15.21)	..LLFEKAAPPAMLE.T...LQPPADVSQDPRHM..VLVRGLVLPVGGGS..AP..GPL..QP...KQQVPLPPaPP
  276-  320 (63.67/11.65)	GATLS..AAPQQS..L......PPVP.PQYQV.............PGNLS..AAQVAAQ..NA...VEAAKNQK.AG
  322-  366 (60.56/10.70)	GP......RFS.....P...INPLQQAPSG.VGPpfSQATAPALPPG......PSGATK..AP...PASQP......
  546-  588 (53.36/ 8.50)	GLIPYDQSGFVNGIRQV...ITNHKQVQQQKLEQ..QRGMGQ................Q..AP...PG........L
  589-  652 (129.67/31.82)	GPILEDQARPSQNLQLQ...LRPPQPQPQGTVGA..SGATGQPQPPGTTQ..APPGAPQ..GP...PGAAPGPP.PP
  653-  712 (81.28/17.03)	GPILRPQ.NPGANPQLRsllLNPP.P.PQ..........TGVPPPQASLHhlQPPGAPAllPP...PHQSLGQP.QL
  713-  756 (60.70/10.74)	GPPLL.HPPPAQSWPAQ...LPPRAPMP.GQMLL..S..................GGPR..GPvpqPGLQP......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.92|      20|      20|     372|     391|       2
---------------------------------------------------------------------------
  372-  391 (40.59/16.67)	VAPGPGLAPT.AQPGAPSMAG
  393-  413 (34.33/12.79)	VAPGGVSGPSpAQLGAPALGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      97.43|      30|     111|      61|      91|       3
---------------------------------------------------------------------------
   61-   91 (53.50/39.57)	YLLPAIEYFN.GGPPAETdFGGDYG..GTQYSLV
  173-  205 (43.93/26.76)	YLLPAVESTTySGYTTES.LVQEIGerGIHFSIV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      80.59|      24|      26|     484|     509|       4
---------------------------------------------------------------------------
  484-  509 (38.89/37.77)	GPLFrnSRMVQF.HFTNKDLESLKGLY
  513-  537 (41.71/32.15)	GNGF..AGCVHFpHTAPCEVRVLMLLY
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28413 with Med25 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GGSAPGPLQPKQQVPLPPAPPSGATLSAAPQQSLPPVPPQYQVPGNLSAAQVAAQNAVEAAKNQKAGLGPRFSPINPLQQAPSGVGPPFSQATAPALPPGPSGATKAPPASQPNLVSTVAPGPGLAPTAQPGAPSMAGTVAPGGVSGPSPAQLGAPALG
2) HKQVQQQKLEQQRGMGQQAPPGLGPILEDQARPSQNLQLQLRPPQPQPQGTVGASGATGQPQPPGTTQAPPGAPQGPPGAAPGPPPPGPILRPQNPGANPQLRSLLLNPPPPQTGVPPPQASLHHLQPPGAPALLPPPHQSLGQPQLGPPLLHPPPAQSWPAQLPPRAPMPGQMLLSGGPRGPVPQPGLQPSVMEDDILMD
254
566
412
766










Molecular Recognition Features






MoRF SequenceStartStop




NANANA