<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28406

Description Cell division cycle 2-like protein kinase 6
SequenceMATTGRKLVAGAGSAGNHLLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIVIDVDDDDELGCVSKEDYVLEPFVMIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDEPEEKADKNQQQQQQNQHQQPTAPPPQAPPQAPPQQQSSTQTNGTTGGVAAGVGGPAAGLQHNQDSSLNQVPPNKKPRLGPSGASSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
Length477
PositionKinase
OrganismHeterocephalus glaber (Naked mole rat)
KingdomMetazoa
LineageEukaryota> Metazoa> Chordata> Craniata> Vertebrata> Euteleostomi> Mammalia> Eutheria> Euarchontoglires> Glires> Rodentia> Hystricomorpha> Bathyergidae> Heterocephalus.
Aromaticity0.08
Grand average of hydropathy-0.599
Instability index55.54
Isoelectric point7.06
Molecular weight53682.12
Publications
PubMed=21993625

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:InterPro
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process
cell division	GO:0051301	IEA:UniProtKB-KW









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28406
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.59|      16|      17|     295|     310|       1
---------------------------------------------------------------------------
  295-  310 (27.30/15.57)	DPTKRITSEQALQDPY
  314-  329 (29.29/17.21)	DPLPTLDVFAGCQIPY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     170.67|      37|      42|     399|     435|       2
---------------------------------------------------------------------------
  352-  395 (46.30/17.41)	QQNQHQQPTAPPPQAPPQAPPQQQS.StqtngttggvaagvGGP.......A
  399-  435 (69.98/29.45)	QHNQDSSLNQVPPNKKPRLGPSGAS.S..............GGPVMPSDYQH
  439-  475 (54.39/21.53)	RLNYQSSV.QGSSQSQSTLGYSSSSqQ..............SAQYHPSHQAH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28406 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) YPKREFLNEDEPEEKADKNQQQQQQNQHQQPTAPPPQAPPQAPPQQQSSTQTNGTTGGVAAGVGGPAAGLQHNQDSSLNQVPPNKKPRLGPSGASSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSAQYHPSHQAHRY
329
477










Molecular Recognition Features






MoRF SequenceStartStop




1) AQYHPSHQAHRY
2) RLNYQSSV
3) STLGYSSS
466
439
454
477
446
461