<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28396

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMGDFPPPERTSVKASELVHRAVDKSYEDFRTLMHQLPTMREEERREPLLAHLQSSRKRFAQILAVLKWSVQSPLLQQCDTLLQQTESYRNNVNETNDRLFFMHADLNRAKERRYDLSTAVDVLYGGSYLRLPTIIKNAMFPRELPEVDTEQAATEVADIIRFRLIEAEIPEQFSNIKLEGGFVTCQAEGEFEIVLTIQGKEKDAKWRVISVNTALTDSQAFEDHSQAASTSALRIIRTNAPNAAHYNHLKNLVQRAMNKSEKPFVDAFQVMREFCSSLALQILASQGKLLMDGRWKNRIMIKHHRDQNVLDICYWPKACTWKEAQALTEQQRLLQQLSDPVANARRGSALPFPESSLCVRLGFDPNKKKLLSVTLSPSLPPNLPGYAALLSALEVPSNMFLLSAENLLIAAMRAHVSAALFSIGRQLVVDSPDDKASTQLVSGEDVSMVCSDTSLRIARADIGGLQQFLEVTFDIREGRFIVSSVAAAKHSALYVTVKQLERILNTQCKIELGGTVDKSFPNDFALVSGDGKGDKSNELIHASVRKVLCEIVADEVAQIGSSFKGIEVLRSVNLNWERYLAFRQQHGGQTEDLTISETALYFQLTSSKESTCYLVIEINKYGEVDGMNGNVHEAAEIEEYVRLPCFSLLQTSAGMPGQPSGVQFIQRFGAFKKEDLHPSVTRHNEIIVNGLRGGSRKRPYGSSGNALVGNSVRSTKKAMLDGGRVQEITGYWLDDAEQQAVSRNFVPHIASVLLHAINMCSERIQLQHFVNFARRRKSRIRYSGEAGTSNGNGTGGQVVTLSFPEKVNTDPLKIIAIQGHLKHGGGFELCLQLASPPFKFILPKEPKEHLLSERSHYVNPRGQLIFKYPTTLVTSELFSENPLEMFMVELICVVRPLCELAVKLEKMLTPVGRYTNDIKSDGHFYVESADPFAIVLACRAPNPRHCIAAGSSPDGMTTYRVTVQFKQKMGFVVNYSHKAEHPLMHFIQSALNGHSDPAQFVEALERTCIPMGILASVVESQLLCAKYYRQDPPPNTKDGAANGGPKAFGRGKMGGKGMKLGYKFKLPGEEKGYYAEKSYGGDDKSFVPAELVMIPRSQTQVRLSYGDRCAVDIYFLENHSVKMQTSSGGVRVPSCPSEKGIVMDCQNFADKLRSTLSEMASA
Length1162
PositionTail
OrganismPhytophthora sojae (strain P6497) (Soybean stem and root rot agent) (Phytophthora megasperma f. sp. glycines)
KingdomOomycetes
LineageEukaryota> Sar> Stramenopiles> Oomycota> Peronosporales> Peronosporaceae> Phytophthora.
Aromaticity0.08
Grand average of hydropathy-0.276
Instability index41.58
Isoelectric point8.27
Molecular weight129290.40
Publications
PubMed=16946064

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28396
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      45.81|      13|      23|     134|     146|       1
---------------------------------------------------------------------------
  134-  146 (23.72/14.58)	IIKNAMFPRELPE
  159-  171 (22.09/13.10)	IIRFRLIEAEIPE
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     139.68|      45|     219|      26|      75|       2
---------------------------------------------------------------------------
   26-   75 (63.45/69.19)	YEDFRTLMHQlpTMREEERrePLLAHLQSSRKrFAQILAVLKWSVQSPLL
  246-  290 (76.23/59.56)	YNHLKNLVQR..AMNKSEK..PFVDAFQVMRE.FCSSLALQILASQGKLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.14|      16|     219|     222|     237|       5
---------------------------------------------------------------------------
  222-  237 (27.42/16.18)	EDHSQAASTSALRIIR
  444-  459 (28.72/17.26)	EDVSMVCSDTSLRIAR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      91.52|      27|     171|     803|     851|       8
---------------------------------------------------------------------------
  176-  202 (47.65/16.73)	IKLEGGFVTC.Q.AEGEFEIVLTIQGKEK
  821-  849 (43.87/24.55)	LKHGGGFELClQlASPPFKFILPKEPKEH
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28396 with Med14 domain of Kingdom Oomycetes
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