<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28391
Description |
Mediator of RNA polymerase II transcription subunit 10 |
Sequence | MVDRNRFEILEENIESIIDHCREAGIVVCDYQPSVSFQKKINDLVYKLQDVDRMQVEMQDVHVPIELFSKIDAGQNPQLYTRECMEQALAKNEAVRGKLDSLRRFRVLLMSELSRQFPNEMAKYRAVRGDPEAPTLGHAMSSNSQSNGSGTETGPESVSLR |
Length | 161 |
Position | Middle |
Organism | Schistosoma mansoni (Blood fluke) |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda>
Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.550 |
Instability index | 56.24 |
Isoelectric point | 5.28 |
Molecular weight | 18319.54 |
Publications | PubMed=22253936
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364146
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP28391
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 96.23| 32| 52| 64| 97| 2
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64- 97 (43.57/34.21) PIELFSKIDAGQNPQLyTREcMEQALAKNEAVRG
98- 129 (52.67/30.50) KLDSLRRFRVLLMSEL.SRQ.FPNEMAKYRAVRG
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