<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28389

Description Serine/threonine kinase
SequenceMVDAEFKRKLNEIREKVEDLFDFEGCKVGRGTYGSVYKAKLKDGTDSRDYALKQIEGTGLSMSACREIALLRELKHPNVITLQRVFLNHTTRRVWLLFDFAEHDLWHIIKFHRTTKANKSTVQVYGNMVKSLMYQILNGIHYLHDNWILHRDLKPANILVMGEGPDRGRVKIGDLGFARLFYQPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTYEPIFHCRQEDIKTSTPYHKEQLERIFRVMGYPPDDAWVDMKKMPDYHQLLRDSISKKTYGKYSLEGYFEEKKFKVDERELALLRRLLTMDPVKRLSAAEAMEDSYFKEGEKPNNDVFGNLPIPYPKREFISDDDSDDKQTGADKNVTQTAQQQNATGGRQTTAHPTGGSGMHTTHPHQSQQQSQQQSQQQQQRGNNAPQPQLPLPQQQQRTNGQPPPLNTQQQQQHMNSGQSNPHTRQLIHQQNNNDDIPSNKRVRLSQGNNDTSIAPPPLPSASTTSTSTTVNSSGILHTNTNKPSITGQSQQLSNITTTTTTSGYANLQQQQPMRNLPPGHMGHPGTSYPRYHH
Length577
PositionKinase
OrganismSchistosoma mansoni (Blood fluke)
KingdomMetazoa
LineageEukaryota> Metazoa> Spiralia> Lophotrochozoa> Platyhelminthes> Trematoda> Digenea> Strigeidida> Schistosomatoidea> Schistosomatidae> Schistosoma.
Aromaticity0.08
Grand average of hydropathy-0.825
Instability index47.56
Isoelectric point8.99
Molecular weight65799.24
Publications
PubMed=22253936

Function

Annotated function 
GO - Cellular Component
GO - Biological Function
ATP binding	GO:0005524	IEA:UniProtKB-UniRule
protein kinase activity	GO:0004672	IEA:InterPro

GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28389
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     192.84|      31|      31|     402|     432|       1
---------------------------------------------------------------------------
  353-  394 (33.73/11.95)	IPYPK.........refisdddsddKQTGA.DKNVTQTAQQ.QNA.............TGGR.............QTTA
  395-  427 (54.79/23.47)	HPTGG..................sgMHTTH.PHQSQQQSQQ.QSQ.............QQQQ.............RGNN
  428-  444 (26.37/ 7.92)	APQPQ.........................lP...........LP.............QQQQ.............RTNG
  445-  460 (24.41/ 6.85)	QPPP.....................................lNTQ.............QQQQ.............HMNS
  461-  493 (23.45/ 6.32)	G................................QSNPHTRQ.LIH.............QQNNnddipsnkrvrlsQGNN
  498-  559 (30.10/ 9.96)	AP.PPlpsasttststtvnssgilhTNTNK.PSIT.GQSQQ.LSNittttttsgyanlQQQQ.............PMRN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     203.93|      46|      47|     140|     185|       3
---------------------------------------------------------------------------
   70-  102 (28.58/15.24)	..........L..LRELKHPNVITLQRvflNHTTRRVWL..LFD..FAE.......
  103-  137 (31.57/17.65)	....HDLWhIIkfHRTTK.AN............KSTVQVyGNM...VKSLM.YQIL
  140-  185 (83.65/59.44)	IHYLHDNW.IL..HRDLKPANILVMGE...GPDRGRVKI.GDLG..FARLF.YQPL
  188-  234 (60.12/40.56)	LADLDPVV.VT..FWYRAPE..LLLGA...RHYTKAIDI.WAIGciFAELLtYEPI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.57|      22|      31|     254|     282|       4
---------------------------------------------------------------------------
  257-  282 (36.44/31.54)	FRVMGYPPDDAW.VDMKKMPdyhqLLR
  293-  315 (31.13/11.36)	YSLEGYFEEKKFkVDERELA....LLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      25.45|       8|      31|     508|     518|       5
---------------------------------------------------------------------------
  508-  518 (10.02/15.16)	TSTSTTvnsSG
  540-  547 (15.44/ 9.78)	TTTTTT...SG
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28389 with CDK8 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AEAMEDSYFKEGEKPNNDVFGNLPIPYPKREFISDDDSDDKQTGADKNVTQTAQQQNATGGRQTTAHPTGGSGMHTTHPHQSQQQSQQQSQQQQQRGNNAPQPQLPLPQQQQRTNGQPPPLNTQQQQQHMNSGQSNPHTRQLIHQQNNNDDIPSNKRVRLSQGNNDTSIAPPPLPSASTTSTSTTVNSSGILHTNTNKPSITGQSQQLSNITTTTTTSGYANLQQQQPMRNLPPGHMGHPGTSYPRYHH
329
577










Molecular Recognition Features






MoRF SequenceStartStop




1) PIPYPKREF
2) YPRYHH
352
572
360
577