<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28382

Description Putative thyroid hormone receptor-associated protein
SequenceMSSFPSLEYRSLKRKEHCPPDVYCQRSEQKEDLMCEDFVKDGFKYTKPVRDEYESCKEESRFLNSDVVWNFYYNVMLKKYECSNFQDFKKRQTTNIRDTVIPAIDMYKEQVSDWFRELSSNVPLQNLGRRVPFFKDKEEILHELLSNKVPITRALWFINISVIQSTAVAETAKKKPRAPQDPTADWSSTLCRLLSRSLEPIYAPVKHNELVSLFNDWDYLFSLLLAMYDSDMADHWEVILWLIKVAETLTSKCASDFPLKFILHYLIKFGRRFTESELLIRRLLYWCCTTFADVVFACTGPKYARSVGTLQGILNEYKDLCTCPLHQNISMSLSSLIIFIVLSCPSAAVWNPLPFDTDYAYFKGSPLDHIPHSLVTLPLPPGEESTSIRKCLSEVEEDIIRRSQLVESGWLIEPCSGNNGENIERLVRLLDILDRHEYHLVREPNPMESLYSRIFNDDSIHVDTSIIVITLCEWAVSPYRIGIYRSIIVACLLEQLKNTFYGDSTMNSSNISNKDTISLSTTPISTTGSNVNETLIKFLDNCTIQLPPFNGEQSLIDNHFMRNLVCLFSELIDREVFDHDYYVRYFIARGVFDTSLHPLAVIDHTLPNKMNTNPLSINNSNTINQSVNTPTNITRTTTTSSSTTGGTNITASTICHSQITTAQHSVKSEFSEDMDRSSVDNPDSVRSEFVTTYSNRHLHYLIQFPIPQDECYTHEQNQRFQLLYGSVRSRDRARYPIRKLIRDICKLFTKKIYLIDVFHGELVFVKMLNGSNFHSTVNPSNEDNNTNTTNITSMNTNSPLSSSSSSSSANPPSTTTTTNPNNSHPLSISTSNVQSHIYMPVPSSIFLFFELIETSLNITSLIFTVIDTLERLKILFENRTHFMTLYMSSLCLRTVGILQRYQNILFTMGDLSSRLFPILIEQVRQVKEPTQCGPLERCILIYLNDLFTSNIVIKTRFTPIYGKAHQKVNALLRRIDPSEGIRQFDPDYANDLMTSSTSSSMDNVTSFRAYAEDLRNKPDSRYSFVCKAILWICQAKTIEQVNYLCGLCAELTCQCSELTCEWLGAFYAILAPHSYIHGYSPLINTIDLSQLCIYDNLSSLIGTLLSRYCFTISDFLRLVICPAMAQGLDNITQPVNSQLESIISLACDHSLLRNTNRKRTRTTQQQHHQHQKDKSKRFKSRHNHRRRRSTHRKSTTKVHSIIQRFLEQDIIPTTIELHSLPLNALTQLVLREICTVSWVRERFYQMTPNQLIRENVLIDKNFTQSQARRLLHIIYWPYDIKWIDIALTNDGLSGAMCHILHHLNIWTLKCTQIEFQLLYAQISFSQQTEVLGYLAQSIVHGFQSQIMNWFDLNNNHNHTVAMATNTKSSIGHLINDLPIIELDDNDPVWLFPSLIAKLPKSLKAQIVKVTSEYVYLIQIIDSLYEQIEYFLLNSRYLVDHLPDNLHTRSIIQKCLKYRLILVGQKFPTIQLDIDSSIRWATLLAQLISHSIIEPESNSKLFYIVYDMLQLLIHTITARSGIEGKHYQTIAKKIRRELMERPPCSGIEYLRPLLLLTKGSYTIFVTGRQPRGGTRGICNNSSNKSNNSKGSNKAGNCLLSNGSRFLTSSSSSHHQLKKYGYQFLGKERFTPWEIYDPSKQSLLLSIHGAINTESILSRIEEQANRLIRHDHFYRMFHPPEFYMAPIYPQILDEEMSGNSVKLGDVGEHEDPDVINKMIKTENSNNNSDGTGGTTNNASISSMFNKGNNTSNSMDVMRESQLLSLNDMVQLSETNLSECPNQFLPISGNNNNNNIRSGDSSGNYHHQSTGVLYDQKHNISSMSCHPTTSLMFNESNPSIKSGNPLDCGNTSMMMSMMMMTTSSGSTNAHTITNSGNNNHNNSSMQLGRGKLLNARNDIEINDKLSLNNRMNAFQSSSSSSGGSLGGGTVGGGGGGGVGVVSSSSSSLQIHSHSQQIHGHHHHQQQMHLDSDQVYTNSTRKLPSQQTVLNDYPNPNELEQQSMNHCVTVAGHMNTMTYPLSHHHNHQLDVNLHKTNKLLGMEYNDRLIASQSSTSSQQQIQMNPTGTPSIPPPSNNATMLSTPMNNNVVAGHVLTSAAKTVTTKRKRGSGRRGGGNITDRNSIRPSGATTRGVTESNHQWTNKQNVYNMNLLEMQQQQQLPSSTRGHHQQQHLANLSGFLRNRAQQHHQQQQQLHPEQSYGSNFSANNPVVLSHQGHVFDQSQLNNQFNQSNTHLIDSPSGSLRRHLTTSGGGAGNVSRSIQQSSQQQSHQILSHTSGTPQQLPPGMPNPPPYPISNHQSQQYSFRAPPSDEANYIMNTNESSIDEQFKRQSVNSAMNSIHQPGTTIMSRSSAYEFPARIHN
Length2359
PositionKinase
OrganismSchistosoma mansoni (Blood fluke)
KingdomMetazoa
Lineage
Aromaticity0.08
Grand average of hydropathy-0.434
Instability index55.71
Isoelectric point7.69
Molecular weight267409.98
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28382
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     582.52|     133|     133|    1668|    1800|       1
---------------------------------------------------------------------------
  771-  831 (50.55/15.53)	.......SNFHSTVNPSN..EDNNTNTTNITSM..NTNSPLSSSSS.SSSANpPST...T.....TTTNPNNSHPLSISTS....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1668- 1732 (78.14/27.70)	........................................................................................................................nvqshiympvpssiflffelietslnitsliftvidtlerlkilfenrthfmtlymsslclrtvgilqryqnilftmgdlssrlfpilieqvrqvkeptqcgplerciliylndlftsniviktrftpiygkahqkvnallrridpsegirqfdpdyandlmtsstsssmdnvtsfrayaedlrnkpdsrysfvckailwicqaktieqvnylcglcaeltcqcseltcewlgafyailaphsyihgysplintidlsqlciydnlssligtllsrycftisdflrlvicpamaqgldnitqpvnsqlesiislacdhsllrntnrkrtrttqqqhhqhqkdkskrfksrhnhrrrrsthrksttkvhsiiqrfleqdiipttielhslplnaltqlvlreictvswvrerfyqmtpnqlirenvlidknftqsqarrllhiiywpydikwidialtndglsgamchilhhlniwtlkctqiefqllyaqisfsqqtevlgylaqsivhgfqsqimnwfdlnnnhnhtvamatntkssighlindlpiielddndpvwlfpsliaklpkslkaqivkvtseyvyliqiidslyeqieyfllnsrylvdhlpdnlhtrsiiqkclkyrlilvgqkfptiqldidssirwatllaqlishsiiepesnsklfyivydmlqllihtitarsgiegkhyqtiakkirrelmerppcsgieylrplllltkgsytifvtgrqprggtrgicnnssnksnnskgsnkagncllsngsrfltssssshhqlkkygyqflgkerftpweiydpskqslllsihgaintesilsrieeqanrlirHDH....FYRM........FHPPEFYMAPIYP........QILDEEMSGNS..VKLGDVGEHEDPDVINKMIKTE..NSNNNSDGTGGT
 1733- 1863 (175.74/70.75)	TNNASISSMFNKGNNTSN..SMDVMRESQLLSL..NDMVQLSETNL.SECPN.QFL...P.....ISGNNNNNNIRSGDSS......................................G..................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................nyHHQstgvLYDQkhnissmsCHPTTSLM...............FNE..SNPS..IKSGNPLDCGNTSMMMSMMMMT..TSS.......GS
 1864- 2009 (142.88/10.12)	TNAHTIT...NSGNNNHNnsSM.................QLGRGKL.LNARN.DIEindK.....LSLNNRMNAFQSSSSSsggslgggtvgggggggvgvvsssssslqihshsqqihG....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................HHH....HQQQ........MH...LDSDQVYT........NSTRKLPSQQT..V.LND...YPNP...NEL..EQ..QSMNHCVTVAGH
 2010- 2078 (46.68/20.84)	MN..TMTYPLSHHHNHQL..DVNLHKTNKLLGMeyNDRLIASQSSTsSQQQI.QMN...PtgtpsIPPPSNNATMLS........................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 2184- 2231 (45.14/13.82)	...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................tpmnnnvvaghvltsaaktvttkrkrgsgrrgggnitdrnsirpsgattrgvtesnhqwtnkqnvynmnllemqqqqqlpsstrghhqqqhlanlsgflrnraqqHHQ....QQQQ........LHP.....EQSYG........SNFS...ANNP..VVLSHQGHVFDQSQLNNQF..N..QSNTH.......
 2278- 2342 (43.39/13.14)	.....................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................QQ........L.PPGMPNPPPYPisnhqsqqYSFRAPPSDEAnyI.MN.....TNESSIDEQFKRQsvNSAMNSIHQPGT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     103.25|      31|     434|     255|     285|       2
---------------------------------------------------------------------------
  255-  285 (55.36/37.13)	SDFPLKFI...LHYLIKF....GRRFTESELLIRRLLY
  687-  724 (47.89/31.01)	SEFVTTYSnrhLHYLIQFpipqDECYTHEQNQRFQLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     183.99|      56|     434|      71|     127|       3
---------------------------------------------------------------------------
   71-  127 (96.19/73.17)	FYYNVMLKKYECSNfQDFKKRQTT.......NIRDTVIPAIDMYKEQVSDWFRELS..SNVPLQNL
  500-  564 (87.80/61.05)	FYGDSTMNSSNISN.KDTISLSTTpisttgsNVNETLIKFLDNCTIQLPPFNGEQSliDNHFMRNL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.39|      20|      86|    1372|    1398|       5
---------------------------------------------------------------------------
 1377- 1398 (32.10/32.40)	LPIIELDDNDPV.WlfPSLIAKL
 1466- 1486 (31.28/12.38)	FPTIQLDIDSSIrW..ATLLAQL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     221.75|      70|     432|     836|     911|       6
---------------------------------------------------------------------------
  836-  911 (115.53/85.48)	H.IYMPVPssiflfFELIETSLNITSLIFTVIDTLERLKI..LFENRTHFMTLYMS.SLCLRT..VG.....ILQRYQNILFTMGDL
 1272- 1352 (106.22/66.59)	HiIYWPYD......IKWIDIALTNDGLSGAMCHILHHLNIwtLKCTQIEFQLLYAQiSFSQQTevLGylaqsIVHGFQSQIMNWFDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      74.66|      25|      86|    1525|    1558|       7
---------------------------------------------------------------------------
  400-  435 (26.07/ 6.44)	IRRsQLVESgwliEPCSGnngenIERLvRLLDILDR
 1533- 1557 (48.59/26.14)	IRR.ELMER....PPCSG.....IEYL.RPLLLLTK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.46|      14|      15|     631|     644|       8
---------------------------------------------------------------------------
  631-  644 (23.11/13.13)	TNITRTTTTSSSTT
  647-  660 (24.35/14.34)	TNITASTICHSQIT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.36|      12|      16|    1080|    1092|       9
---------------------------------------------------------------------------
 1080- 1092 (18.56/14.28)	SPLINTIdLSQLC
 1098- 1109 (22.80/12.34)	SSLIGTL.LSRYC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.19|      14|      20|     978|     992|      10
---------------------------------------------------------------------------
  978-  992 (22.21/20.53)	S..EGIRQFDPdYANDL
  999- 1014 (19.98/11.69)	SsmDNVTSFRA.YAEDL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.29|      14|      18|    2102|    2118|      11
---------------------------------------------------------------------------
 2102- 2118 (21.07/20.92)	RKRGSGRRGggnITDRN
 2121- 2134 (26.22/15.02)	RPSGATTRG...VTESN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.99|      14|      18|    1195|    1208|      12
---------------------------------------------------------------------------
 1195- 1208 (23.70/17.53)	TTKVHSIIQRFLEQ
 1214- 1227 (23.29/17.06)	TIELHSLPLNALTQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.56|      31|     316|    1920|    1950|      14
---------------------------------------------------------------------------
 1920- 1950 (58.12/39.00)	GSLG.GGTVGGGGGGGVGVV...SSSSSSLQIHSH
 2238- 2272 (48.44/31.04)	GSLRrHLTTSGGGAGNVSRSiqqSSQQQSHQILSH
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28382 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) GNSVKLGDVGEHEDPDVINKMIKTENSNNNSDGTGGTTNNASISSMFNKGNNTSNSMDVMRESQLLSLNDMVQL
2) LGMEYNDRLIASQSSTSSQQQIQMNPTGTPSIPPPSNNATMLSTPMNNNVVAGHVLTSAAKTVTTKRKRGSGRRGGGNITDRNSIRPSGATTRGVTESNHQWTNKQNVYNMNLLEMQQQQQLPSSTRGHHQQQHLANLSGFLRNRAQQHHQQQQQLHPEQSYGSNFSANNPVVLSHQGHVFDQSQLNNQFNQSNTHLIDSPSGSLRRHLTTSGGGAGNVSRSIQQSSQQQSHQILSHTSGTPQQLPPGMPNPPPYPISNHQSQQYSFRAPPSDEANYIMNTNESSIDEQFKRQSVNSAMNSIHQPGTTIMSRSSAYEFPARIHN
3) LSECPNQFLPISGNNNNNNIRSGDSSGNYHHQSTGVL
4) MNTNPLSINNSNTINQSVNTPTNITRTTTTSSSTTGGT
5) NRKRTRTTQQQHHQHQKDKSKRFKSRHNHRRRRSTHRK
6) STVNPSNEDNNTNTTNITSMNTNSPLSSSSSSSSANPPSTTTTTNPNNSHPL
7) TSMMMSMMMMTTSSGSTNAHTITNSGNNNHNNSSMQLGRGKLLNARNDIEINDKLSLNNRMNAFQSSSSSSGGSLGGGTVGGGGGGGVGVVSSSSSSLQIHSHSQQIHGHHHHQQQMHLDSDQVYTNSTRKLPSQQTVLNDYPNPNELEQQSMNHCVTVAGHMNTMTYPLSHHHNHQLDVNLHKTNK
1696
2036
1774
610
1156
775
1848
1769
2359
1810
647
1193
826
2034










Molecular Recognition Features






MoRF SequenceStartStop




NANANA