<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28380

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMSSMSQSTGPNDASLEHCFTNIFALTDFSGIQYRKYILHTPKEYHDPLNDPIIKSYTLCQKYGVLSAWVRSKPESSDLSNPCAFSKFAKELWVFWYGNDDFPNADSCILPELRREDHGNWRQGLSYETRTVLFRALHNVVERCLLTKGFVRLGKWFVQPRKCGCNDDNVQYSVSFSFFLHGESTVCASLDIRQHAAVQRVGVEHIQSCIASQSTIPVILAPYGISAELTGFGFEKKDGDLMVESEAWSTFYPLKSSHECYPAMSGVTGLPFFAMATPTHQNPRQQNKFSSDKKRTVEEINRRCPDTPPKFVEVIVDGFRMRYPMCFVLITSVNDSPSQSDYNPTPYDEAIHLSDVSGHNLSTNVSVPYMSNKCPMYNAHIPNKMKTSRFWRVNKRRKRPSIKMNTPGTSLLKSIIPSSSLQSDFLVDVRHIYLAGRTLQCASQHNRLPSMKPEWQSKRSHSTDKSDMSCSTDGLTTSVSPEMCSLYIQDPCTILQCCCNRFSRVRRTSVGGSFHQQDPFIRRSLKSSIHFNVPPCDRPRTPLPMITTNLTATHDPSMPTLSPQQPAPNQNSNLSSNTLNELNNDLACDHNTSQTTPSSTHLSTAPQPPSLLPKPESNSDLSSVVKIPNGLVTTDSPVSSDHQTQYAKMSARHIPIASVSVMKRNLFNTWLARHAAQELQKESSNDIKRPNLCLNIPDRIEREQYICPEGITLQSAIEQSSPSFPNYSIVEDNTLYKENNVTTDEYSFRNKRPRTAICRTDFNECSLNDGAQGITTDITNVNFTSANSYSPDMKVGVTECNGLIDDQHINPGGLETNIHSGLMHSNGSIMNNSSGTFSRNVGLITHRGVSLASSTGSGPIGPAELALMLPTPPSHDAPQPSPVDGVSVSTNRMNPSTTSVSTPGPGSPSVQTIQDSLSSSVTDTSSHSIPVPFQSVNSPSSCQNQGLWHLAKLPCIQNLGSVSMESQDWSFVQPCAAYLGITSNYQIPHDEISSFSKSLPQLKWSYDHRASNQKSVTSDCVDPHFTPNGLIVNTGNQSATSKSWLMSPNSFPPTSLHRNVANTNNKPCSPQQLNESGTTCSITGFVKSADRTNPNTSYVEDFTEWLSSLLETNGLLVNLILSDSMLNLFKDHNFDSCNICECTSSILGSEIGLYLSNSISTTSPCSKSGRTNTSTFGGHDLVGGSGFHFTRGCKCGFSAVMNQKYVVNGNLFYEDEIEVTRLSVRSSLSQNNENPYTRPPNYRTRQGWWVTSSHPSVSHLLLLQRIMSSVFEEFSVRQITDQLRWNMLSCDQVIKENKLEYDNACALISSAIRNAVETVRPRRVVGHADNIDSITTGTPHSASETGAYIHPSFFLKAHSKMPQNQNDQIRLLTTMRPWLQEAISSTRMLESNYTVDGPLTWKAFHQLAGRGSDETCKPQPIPQLRVSSCDLENLLISPFALRDWDRLSLFPLSRPKRIAYAVILPSDSHMLSDSTSNIPNVLMSDGTDTNSFSSTSNSLRRTLVDFLKELSHTYEACHLGQHFPYYKPEAGSPDTAFIPVFPNPERLSISESDNFVSIHPDLLKTLTEQLGNHSLCGESVLRIIQNYACSSVNSAIAALKKHGVAVEFCSDTNLRSALFPPFDSIKSEKPSIPVKISQDDIKLNIVNRPSVSSRMDSSCSVRYSNGEGSFTTSLDTSSWGAGSDVYLVIYILNPFCYLYDVSMELGRLVMQSLIGSANHILNSLPESWRSRVTTQILSVDHVMSDYLPRLRPLALAIYTSVNRFIEPSLINANRTLTGIGPAAEKEIISNEKDSFHKRTIFAPPYTLMNSRGVLSQLDISSEPIDRSSVLFVAYCLSQDQQWLLATFTDEQGGLLDHTLINIRVPTRYFTEIENQRFQPTESNKHILSPRRIGLARLWDYIINLISQTANAWRLVVGRIGRLGQGELKGWNGLLGRKSLQDVNKFFRERCSACSTSSCVPSHSSSINNGSKPMLNLINSFTGASSCTHELPSLISACLVSLEPQSTFRVYPGFANASPLAMRMMSLLDTPTTSTETPSATHILVFPTSTSASGVSEHEPSGLAEVIYGMGSDDMNVFDWLLPNDPGLDDLVPPNGSTAEMLADFGNPSELNFGLSDLGPPVCVSGVNDGMGKSSNTRLGDGSDVLHGHNEYTVGFHDNRGHGCSDVMGLRGLDSGLLDLGPNHVSNVGGYLSEHLFDHAVNPLNTMPFGIHDPTDEVGSLMQQPLAMGYYISTASAGPLPSWFWIACPHSKFQYPVCLKSALHLQTTLIGVDDAAAAAPPPTGGSSGPGVGPSSNRPGHLLDSNSTCDVLRYVLETYNALSWLTIDPTTNDRRTCLPIHILSLSQIYQAFEAFT
Length2353
PositionMiddle
OrganismSchistosoma mansoni (Blood fluke)
KingdomMetazoa
Lineage
Aromaticity0.08
Grand average of hydropathy-0.340
Instability index52.99
Isoelectric point6.22
Molecular weight259354.66
Publications









Function






Annotated function


GO - Cellular Component
GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28380
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.24|      19|      28|    2081|    2108|       1
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 2060- 2078 (34.51/ 9.42)	GLAEVIYGMGSDDMNVFDW
 2085- 2103 (34.74/34.04)	GLDDLVPPNGSTAEMLADF
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      83.41|      25|      28|     877|     904|       2
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  880-  904 (46.11/28.43)	SP.VDGVSVSTNRMNPSTTSVSTPGP
  906-  931 (37.30/13.54)	SPsVQTIQDSLSSSVTDTSSHSIPVP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     106.27|      32|      32|    1979|    2010|       3
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 1979- 2010 (58.35/33.79)	FTGASSCTHELPSLISACLVSLE.PQST.FRVYP
 2012- 2045 (47.92/26.27)	FANASPLAMRMMSLLDTPTTSTEtPSAThILVFP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.64|      22|      28|    1022|    1046|       4
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  720-  745 (30.53/11.96)	SPSF.PNYSIVedNTlyKENNVTTDEY
 1021- 1043 (38.11/24.30)	DPHFtPNGLIV..NT..GNQSATSKSW
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.97|      20|      32|    2124|    2155|       5
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 1168- 1187 (38.49/18.60)	GRTNTSTFG.GHDLVGGS.....GFH
 2130- 2155 (29.48/45.49)	GKSSNTRLGdGSDVLHGHneytvGFH
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     105.78|      24|      32|     960|     983|       6
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  556-  571 (20.77/ 6.03)	..SMPTL..SPQQPAPNQNS....
  960-  983 (42.33/19.56)	SVSMESQDWSFVQPCAAYLGITSN
  995- 1018 (42.68/19.78)	SKSLPQLKWSYDHRASNQKSVTSD
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      50.33|      14|     893|     331|     346|       7
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  331-  346 (23.64/19.58)	SVNDSPSQSDYNptPY
 1222- 1235 (26.69/14.24)	SVRSSLSQNNEN..PY
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     125.60|      30|     893|     573|     602|       8
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  573-  602 (50.61/32.36)	LSS.....NTLNELNNDLACDHNTSQTTPSSTHLS
  620-  654 (42.51/25.78)	LSSvvkipNGLVTTDSPVSSDHQTQYAKMSARHIP
  658-  682 (32.48/17.63)	VSV.....MKRNLFNTWLA.RHAAQELQKES....
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      85.15|      26|      32|    2165|    2194|       9
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 2165- 2194 (36.74/29.97)	VMGLRGLDSGLLDlgPnhVSNVGGYLSEHL
 2199- 2224 (48.41/25.72)	VNPLNTMPFGIHD..P..TDEVGSLMQQPL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      86.39|      27|     892|     751|     777|      10
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  751-  777 (48.30/28.76)	RPRTAICRTDFNEC.SLNDGAQ....GITTDI
  786-  817 (38.09/21.04)	NSYSPDMKVGVTECnGLIDDQHinpgGLETNI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.45|      22|     892|     821|     870|      11
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  839-  861 (35.23/48.19)	NVGLITHRGVSLASSTGSgPIGP
 1329- 1350 (41.22/ 6.10)	NIDSITTGTPHSASETGA.YIHP
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     370.90|     148|     181|    1447|    1626|      14
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 1050- 1135 (80.94/34.52)	FP.PTSLhrNVANTNN....KPCSPQQLNESGTTCSITGfvKSADRTNPNtsYVEDFTEWLSSLLETNGLLVNLiLSDSML..NLFKDhnFDS.......................................................................................................................................................................................................................................................................................................................................................................................................
 1447- 1520 (71.88/69.04)	.............................................................................................cnicectssilgseiglylsnsisttspcsksgrtntstfgghdlvggsgfhftrgckcgfsavmnqkyvvngnlfyedeievtrlsvrsslsqnnenpytrppnyrtrqgwwvtsshpsvshllllqrimssvfeefsvrqitdqlrwnmlscdqvikenkleydnacalissairnavetvrprrvvghadnidsittgtphsasetgayihpsfflkahskmpqnqndqirllttmrpwlqeaisstrmlesnytvdgpltwkafhqlagrgsdetckpqpipqlrvsscdlenllispfalrdwdrlSLfPLS.RPKRIAYAVI.LPSDSHMLsDSTSNIpNVLMSDGTDTNSFSSTS...NSLRRTLVDFLKELSHTYE.ACHLGQ
 1540- 1706 (218.08/137.61)	FPnPERL..SISESDNfvsiHPDLLKTLTEQLGNHSLCG..ESVLRIIQN..YACSSVNSAIAALKKHGVAVEF.CSDTNLrsALFPP..FDS.................................................................................................................................................................................................................................................................................................................iksekpSI.PVKiSQDDIKLNIVnRPSVSSRM.DSSCSV.RYSNGEGSFTTSLDTSSwgaGSDVYLVIYILNPFCYLYDvSMELGR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     182.11|      53|     157|     274|     329|      15
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  274-  329 (93.78/73.64)	MATPTHQNPRQQNKFSSDKKrtvEEINRRCPDTPPKFVEVIVDGFRMRY.P.MCFVLI
  433-  487 (88.33/61.07)	LAGRTLQCASQHNRLPSMKP...EWQSKRSHSTDKSDMSCSTDGLTTSVsPeMCSLYI
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     150.98|      47|    1747|      30|      78|      16
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   30-   78 (82.45/64.27)	GIQYRKYILHTPKE.YHDplNDPIIKSYTLCQKYGVLSAW.VRSKP..ESSDL
 1779- 1829 (68.53/45.88)	GPAAEKEIISNEKDsFHK..RTIFAPPYTLMNSRGVLSQLdISSEPidRSSVL
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      81.39|      27|      29|    1871|    1898|      17
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 1871- 1898 (43.49/34.84)	IENQRFQPTESNKHILSpR..RIGLARL..WD
 1900- 1930 (37.90/23.98)	IINLISQTANAWRLVVG.RigRLGQGELkgWN
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     131.27|      41|     965|     387|     427|      19
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  387-  427 (70.48/37.29)	SRFWRVNKR...RKRPSIKMNTPGTSLLKSIIPSSS.LQSDFLVD
 1351- 1395 (60.79/31.18)	SFFLKAHSKmpqNQNDQIRLLTTMRPWLQEAISSTRmLESNYTVD
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28380 with Med13 domain of Kingdom Metazoa
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