<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP28372

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTGDYDTNTLLINNLSAISFRVYEPVAANTASYTFQPQVVEDALRRDGHLVHVDTTRRCIWVFYLTTKDGSMLGPEERGLTAKMEVCGYSLGLSGEGGFEPSSLFRSRQLGTNSLNTPNSSSSAGSAVDATFRNPQASAFPTAAGAMPGAPVMDNKGASHILSDSDRFAHVPLKEKYDFFITATLASLSSSLCHTIGAIPLDHRSILLPSQAYYLDEFILGPKPQTCALGTFRVYLTSTGTLVISLSVSLLEGLASFAELARSNMLPSNPVVLAAPLGAFGFMLNPVDGDIYGLDSGYGHSPDTQISRLRPDPTTDRLSQWKATCCKVLQMRGISPSLINGCSWFNVHFLQRKPYEHRQDAKRPPLTNPPQIAAWPSVLCFRKPRIDAGADSRSSKALVASAPESLDPVDDARQWCQGFPEREETIAKRKKERDEREALAAVSRSIADADSKNNQISAASPMALRRPSNGGAIAASSAMYPTPPDGIQPLGMAASAETGFAASPANQPQHNAMTGIVTVTKNNAPHTENFGNGWEGGDNKREQQAGNLLEGDNMFGDLGEDMFEGNELTDADFNFFDEQLNEQPEGVEMNFSAISGLGTTTDLSADTGQPTNSAPQANNRVEEYKTVPQPAPPEFTKPELKHARSTLAEGSRQQANQESFNRNSTIGIKRQHSPFNRETVYKRIKASLRSPPKPRSPTTAVSQRRKSEFDKVDFDPSLSLVNKKYTENGPFNYMIPAVQEMQKTRLELQNPLLTRVEKPPKEPPSNFGALLARIAHGIGGSLTGRDEVASETDDSSWASDPDDLSDESNYAPSLAKSGISRRRLDDDVLSTAASFKDLESAVADTPAYGSIDLVRLSHPEVPEFSIAKYFADPEPARLQVSCSDMDFITIAQILTEQVATGSLQIAPKILSRKPQDVRRTLAKAVRYSMQGLRKALPRSLADAVECSLKPYADVQDVPLVALAQPQRIQAKPMGSEMSTRNIYPIPTPHIEIRRYETPFSMLPTAISFWESLGLSPAKGAKDIVSVCVFPNVDGLRDSASAFLQRIRSVYESLKLGTFDILPTVLELEDGLLSYFATQQPAVRDEWAVSPFDGPMSCLADALTSVQITEKNFVVFFVYPDDRPSSVVETCAAFHDLYERYKRCMADNRKPVTSELVLQLVPLDCIASDTTVTVMSPVDYMKLCLETYDRCTLFGGPMPAPAIVLEPQVLRTIDFKLNTNPSPNLLQENSCMHVAYAQSVDERWITAAWTDYRGTRQMTTSYCLGRRDRPLTRSITEIIQQIWEATMDHIHFARVHWRVVVTKCSPMEQQEIEYWASLQQSETYANVSLTLLTVDTNPSLQLIPPAQRIQIPSAALSSNSPASTPQASVLSPDQSGLGPPTPIGTGSSNSANAATDNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNNTTTTTTTTTDSDADSTLVDQLDMTWAVIAAHRLNNSTSLTELNQALASGYLVKRGGPKLEDVPVTMEVNVIHCEGINIPQPHQYPRVYEQLLKEMLSHFRGLGTLARARGVVDRETDVRPWHVAVAEKAVRALYLLM
Length1570
PositionKinase
OrganismNeurospora tetrasperma (strain FGSC 2509 / P0656)
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora.
Aromaticity0.07
Grand average of hydropathy-0.413
Instability index47.65
Isoelectric point5.43
Molecular weight172183.23
Publications
PubMed=21750257

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP28372
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      78.19|      15|      15|    1397|    1411|       1
---------------------------------------------------------------------------
 1391- 1409 (28.34/16.29)	ANaatdNNNNNNNNNNNNN
 1410- 1425 (30.67/18.15)	NN...nNNNNNNNNNNNNN
 1426- 1433 (19.17/ 8.95)	NN...........NNNNNN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.31|      18|      20|     547|     566|       2
---------------------------------------------------------------------------
  549-  566 (33.17/23.69)	LLEGD.NMFGDLGEDMFEG
  569-  587 (28.14/11.97)	LTDADfNFFDEQLNEQPEG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      42.22|      12|      18|     920|     931|       4
---------------------------------------------------------------------------
  920-  931 (21.35/16.51)	RTLAKAVRYSMQ
  939-  950 (20.86/15.94)	RSLADAVECSLK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      58.59|      18|      19|     669|     686|       6
---------------------------------------------------------------------------
  669-  686 (31.38/20.71)	IKRQHSPFNRET.VYKRIK
  689-  707 (27.21/16.74)	LRSPPKPRSPTTaVSQRRK
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.74|      13|      19|    1199|    1211|       8
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 1199- 1211 (21.85/12.42)	PAPAIVLEPQVLR
 1221- 1233 (24.89/15.29)	PSPNLLQENSCMH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.00|      11|      19|    1144|    1154|      10
---------------------------------------------------------------------------
 1144- 1154 (21.43/15.80)	CMA.DNRKPVTS
 1165- 1176 (15.57/ 9.13)	CIAsDTTVTVMS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.03|      13|      32|     830|     842|      11
---------------------------------------------------------------------------
  830-  842 (21.35/10.96)	LSTAASFKDLESA
  865-  877 (24.68/13.78)	FSIAKYFADPEPA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     140.89|      46|     687|     303|     353|      12
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  303-  353 (73.10/71.77)	PDTQISRLR.P...DPTTdrLSQWKATccKVLQMRGiSPSLINGCSWFNVH........FLQR
  989- 1046 (67.79/46.40)	PHIEIRRYEtPfsmLPTA..ISFWESL..GLSPAKG.AKDIVSVCVFPNVDglrdsasaFLQR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     121.27|      39|     687|      71|     111|      13
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   71-  111 (64.61/43.60)	GSMLGPEErgLTAKMEVCGYSL...GLSGEGGFEPS...SLFRSRQL
  781-  825 (56.66/31.87)	GSLTGRDE..VASETDDSSWASdpdDLSDESNYAPSlakSGISRRRL
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP28372 with Med13 domain of Kingdom Fungi
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