Description | Mediator of RNA polymerase II transcription subunit 21 |
Sequence | MSDRLSQLQEAVDQLMEQFIATYFYIDRHHDLKTFSPKDTIAPSKADQPPEVDTLPPDVFQAGQLELARDLITREQQIEYLISSLPGLDNSEQDQLQSIKELEEELNVAEKQRQEAVKEKDEVLVKLDQTLRSIRRY |
Length | 137 |
Position | Middle |
Organism | Neurospora tetrasperma (strain FGSC 2509 / P0656) |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Sordariomycetidae> Sordariales> Sordariaceae> Neurospora. |
Aromaticity | 0.06 |
Grand average of hydropathy | -0.732 |
Instability index | 64.01 |
Isoelectric point | 4.53 |
Molecular weight | 15929.64 |
Publications | PubMed=21750257 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 ARBA:ARBA00003669 ECO:0000256 RuleBase:RU366036 |
GO - Cellular Component | core mediator complex GO:0070847 IEA:EnsemblFungi mediator complex GO:0016592 IEA:UniProtKB-UniRule |
GO - Biological Function | RNA polymerase II repressing transcription factor binding GO:0001103 IEA:EnsemblFungi transcription coactivator activity GO:0003713 IEA:EnsemblFungi transcription corepressor activity GO:0003714 IEA:EnsemblFungi |
GO - Biological Process | negative regulation of transcription by RNA polymerase II GO:0000122 IEA:EnsemblFungi positive regulation of transcription by RNA polymerase II GO:0045944 IEA:EnsemblFungi |
Binary Interactions |
Repeats | >MDP28365 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 86.37| 27| 33| 50| 77| 1 --------------------------------------------------------------------------- 50- 77 (42.15/26.61) PEVDTLPPDVFQAGQlELARDLITREQQ 86- 112 (44.22/24.03) PGLDNSEQDQLQSIK.ELEEELNVAEKQ --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) SPKDTIAPSKA 2) VDTLPPDVFQAGQLELARDLITREQQIEYLISSLPGLDNSEQDQLQSIKELEEEL | 36 52 | 46 106 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab